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Meeting Abstracts

375-OR: Epigenetic Control of Beta-Cell Stress Response and Senescence

SNEHA S. VARGHESE, NAZIA PARVEEN, JEAN K. WANG, ALESSANDRO G. HERNANDEZ-DE LA PENA, SANGEETA DHAWAN

Diabetes 2023;72(Supplement_1):375-OR

https://doi.org/10.2337/db23-375-OR

Published: 20 June 2023

View article titled, 375-OR: Epigenetic Control of Beta-Cell Stress Response and Senescence

Meeting Abstracts

1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes

FEI HUANG, ABHISHEK KULKARNI, FAROOQ SYED, DAVID J. MALONEY, SARAH A. TERSEY, RAGHAVENDRA G. MIRMIRA

Diabetes 2022;71(Supplement_1):1469-P

https://doi.org/10.2337/db22-1469-P

Published: 01 June 2022

View article titled, 1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes

Meeting Abstracts

212-LB: Decreasing Drp1 Expression in Mouse Liver Activates the Mitochondrial Integrated Stress Response and Exacerbates NASH

JANOS STEFFEN, JENNIFER NGO, SHENG-PING WANG, HENNING F. KRAMER, LISA D. NORQUAY, ALESSANDRO POCAI, ORIAN SHIRIHAI, MARC LIESA

Diabetes 2022;71(Supplement_1):212-LB

https://doi.org/10.2337/db22-212-LB

Published: 01 June 2022

View article titled, 212-LB: Decreasing Drp1 Expression in Mouse Liver Activates the Mitochondrial Integrated Stress Response and Exacerbates NASH

Journal Articles

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Bernat Elvira, Valerie Vandenbempt, Julia Bauzá-Martinez, Raphaël Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew L. Winder, Manoja K. Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban N. Gurzov

Diabetes 2022;71(4):653–668

https://doi.org/10.2337/db21-0443

Published: 19 January 2022

View article titled, PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Journal Articles

Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells

Rohit B. Sharma, Huguet V. Landa-Galván, Laura C. Alonso

Diabetes 2021;70(11):2431–2443

https://doi.org/10.2337/dbi20-0033

Published: 22 October 2021

View article titled, Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells

Meeting Abstracts

175-OR: The Mitochondrial Life Cycle Determines ß-Cell Maturity through Activation of the Integrated Stress Response

GEMMA PEARSON, NATHAN LAWLOR, JIE ZHU, EMILY M. WALKER, EMMA C. RECK, MICHAEL L. STITZEL, SCOTT SOLEIMANPOUR

Diabetes 2021;70(Supplement_1):175-OR

https://doi.org/10.2337/db21-175-OR

Published: 01 June 2021

View article titled, 175-OR: The Mitochondrial Life Cycle Determines ß-Cell Maturity through Activation of the Integrated Stress Response

Journal Articles

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes

Helmut Hiller, Dawn E. Beachy, Joseph J. Lebowitz, Stefanie Engler, Justin R. Mason, Douglas R. Miller, Irina Kusmarteva, Laura M. Jacobsen, Amanda L. Posgai, Habibeh Khoshbouei, Richard A. Oram, Desmond A. Schatz, Andrew T. Hattersley, Bernd Bodenmiller, Mark A. Atkinson, Harry S. Nick, Clive H. Wasserfall

Diabetes 2021;70(8):1885–1897

https://doi.org/10.2337/db21-0070

Published: 25 May 2021

View article titled, Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes

Meeting Abstracts

2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

ALEXIS VIVOLI, ANNE-LAURE CASTELL, ALAIN PACIS, ROBERT M. SLADEK, JULIEN GHISLAIN, VINCENT POITOUT

Diabetes 2020;69(Supplement_1):2098-P

https://doi.org/10.2337/db20-2098-P

Published: 01 June 2020

View article titled, 2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

Journal Articles

Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca²⁺ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

Xiaodun Yang, Sarah M. Graff, Cody N. Heiser, Kung-Hsien Ho, Bob Chen, Alan J. Simmons, Austin N. Southard-Smith, Gregory David, David A. Jacobson, Irina Kaverina, Christopher V.E. Wright, Ken S. Lau, Guoqiang Gu

Diabetes 2020;69(6):1219–1231

https://doi.org/10.2337/db19-0721

Published: 03 April 2020

View article titled, Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca<sup>2+</sup> Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

Meeting Abstracts

322-LB: Balancing Act: Atf6alpha Plays Positive and Negative Roles in the Pancreatic Beta-Cell Stress Response

ROHIT B. SHARMA, CHRISTINE O. DARKO, BRIAN GABLASKI, LAURA C. ALONSO

Diabetes 2019;68(Supplement_1):322-LB

https://doi.org/10.2337/db19-322-LB

Published: 01 June 2019

View article titled, 322-LB: Balancing Act: Atf6alpha Plays Positive and Negative Roles in the Pancreatic Beta-Cell Stress Response

Meeting Abstracts

40-OR: The Role of TALK-1 K⁺ Channels in Pancreatic ß-Cell Insulin Secretion, Mitochondrial Function, and the ER Stress Response

SARAH M. GRAFF, PRASANNA DADI, CHLOE E. IBSEN, MATTHEW DICKERSON, KELLI L. JORDAN, DAVID JACOBSON

Diabetes 2019;68(Supplement_1):40-OR

https://doi.org/10.2337/db19-40-OR

Published: 01 June 2019

View article titled, 40-OR: The Role of TALK-1 K<sup>+</sup> Channels in Pancreatic ß-Cell Insulin Secretion, Mitochondrial Function, and the ER Stress Response

Meeting Abstracts

1949-P: Elevated FGF-21 during Circadian Misalignment in Healthy Humans

JOSIANE L. BROUSSARD, SARAH J. MORTON, KATHLEEN MARKAN, ANDREW W. MCHILL, JANINE HIGGINS, EDWARD MELANSON, KENNETH WRIGHT, JR.

Diabetes 2019;68(Supplement_1):1949-P

https://doi.org/10.2337/db19-1949-P

Published: 01 June 2019

View article titled, 1949-P: Elevated FGF-21 during Circadian Misalignment in Healthy Humans

Journal Articles

Insulin Resistance Is Associated With Diminished Endoplasmic Reticulum Stress Responses in Adipose Tissue of Healthy and Diabetic Subjects

Guenther Boden, Peter Cheung, Karen Kresge, Carol Homko, Ben Powers, Lucas Ferrer

Diabetes 2014;63(9):2977–2983

https://doi.org/10.2337/db14-0055

Published: 16 August 2014

View article titled, Insulin Resistance Is Associated With Diminished Endoplasmic Reticulum Stress Responses in Adipose Tissue of Healthy and Diabetic Subjects

Journal Articles

Stress Response Signaling Pathways May Lead to Mitochondrial Biogenesis

Min Luo, Mei-ling A. Joiner

Diabetes 2014;63(6):1831–1832

https://doi.org/10.2337/db14-0373

Published: 15 May 2014

View article titled, Stress Response Signaling Pathways May Lead to Mitochondrial Biogenesis

Journal Articles

The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival

Wendy M. McKimpson, Jeremy Weinberger, Lech Czerski, Min Zheng, Michael T. Crow, Jeffrey E. Pessin, Streamson C. Chua, Jr., Richard N. Kitsis

Diabetes 2013;62(1):183–193

https://doi.org/10.2337/db12-0504

Published: 13 December 2012

View article titled, The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival

Includes: Supplementary data

Journal Articles

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

Sílvia Casas, Ramon Gomis, Fiona M. Gribble, Jordi Altirriba, Sakari Knuutila, Anna Novials

Diabetes 2007;56(9):2284–2294

https://doi.org/10.2337/db07-0178

Published: 01 September 2007

View article titled, Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

Includes: Supplementary data

Journal Articles

Diabetes Alters Sphingolipid Metabolism in the Retina: A Potential Mechanism of Cell Death in Diabetic Retinopathy

Todd E. Fox, Xianlin Han, Samuel Kelly, Alfred H. Merrill, Jr., Rex E. Martin, Robert E. Anderson, Thomas W. Gardner, Mark Kester

Diabetes 2006;55(12):3573–3580

https://doi.org/10.2337/db06-0539

Published: 01 December 2006

View article titled, Diabetes Alters Sphingolipid Metabolism in the Retina: <subtitle>A Potential Mechanism of Cell Death in Diabetic Retinopathy</subtitle>

Journal Articles

Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

Holger Schmid, Anissa Boucherot, Yoshinari Yasuda, Anna Henger, Bodo Brunner, Felix Eichinger, Almut Nitsche, Eva Kiss, Markus Bleich, Hermann-Josef Gröne, Peter J. Nelson, Detlef Schlöndorff, Clemens D. Cohen, Matthias Kretzler, for the European Renal cDNA Bank (ERCB) Consortium

Diabetes 2006;55(11):2993–3003

https://doi.org/10.2337/db06-0477

Published: 01 November 2006

View article titled, Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

Includes: Supplementary data

Journal Articles

Low Stress Response Enhances Vulnerability of Islet Cells in Diabetes-Prone BB Rats

Kerstin Bellmann, Liu Hui, Jürgen Radons, Volker Burkart, Hubert Kolb

Diabetes 1997;46(2):232–236

https://doi.org/10.2337/diab.46.2.232

Published: 01 February 1997

View article titled, Low Stress Response Enhances Vulnerability of Islet Cells in Diabetes-Prone BB Rats

Journal Articles

Secretory Capability of Islets Transplanted Intraportally in the Diabetic Rat

D G Pipeleers, MD,PhD, M A Pipeleers-Marichal, MD, I E Karl, PhD, D M Kipnis, MD

Diabetes 1978;27(8):817–824

https://doi.org/10.2337/diab.27.8.817

Published: 01 August 1978

View article titled, Secretory Capability of Islets Transplanted Intraportally in the Diabetic Rat

NARROW

375-OR: Epigenetic Control of Beta-Cell Stress Response and Senescence

1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes

212-LB: Decreasing Drp1 Expression in Mouse Liver Activates the Mitochondrial Integrated Stress Response and Exacerbates NASH

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells

175-OR: The Mitochondrial Life Cycle Determines ß-Cell Maturity through Activation of the Integrated Stress Response

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes

2098-P: Transcriptomic Changes Associated with Oleate-Induced ß-Cell Proliferation in Rat Islets

Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca²⁺ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

322-LB: Balancing Act: Atf6alpha Plays Positive and Negative Roles in the Pancreatic Beta-Cell Stress Response

40-OR: The Role of TALK-1 K⁺ Channels in Pancreatic ß-Cell Insulin Secretion, Mitochondrial Function, and the ER Stress Response

1949-P: Elevated FGF-21 during Circadian Misalignment in Healthy Humans

Insulin Resistance Is Associated With Diminished Endoplasmic Reticulum Stress Responses in Adipose Tissue of Healthy and Diabetic Subjects

Stress Response Signaling Pathways May Lead to Mitochondrial Biogenesis

The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

Diabetes Alters Sphingolipid Metabolism in the Retina: A Potential Mechanism of Cell Death in Diabetic Retinopathy

Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

Low Stress Response Enhances Vulnerability of Islet Cells in Diabetes-Prone BB Rats

Secretory Capability of Islets Transplanted Intraportally in the Diabetic Rat

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