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Meeting Abstracts

1369-P: The Differential Effects of Estrogen on Determinants of Skeletal Muscle Bioenergetics with a High-Fat, High-Sucrose Diet in Rats

NICHOLAS A. HULETT, SARA HULL, LESLIE KNAUB, GREGORY POTT, BENJAMIN F. MILLER, JANE REUSCH, REBECCA L. SCALZO

Diabetes 2022;71(Supplement_1):1369-P

DOI: https://doi.org/10.2337/db22-1369-P

Published: 01 June 2022

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Meeting Abstracts

1210-P: Subcutaneous-Depot Specific Adiposity Change Is Associated with the Ectopic Fat Depot and Tissue Damage in High-Fat High-Sucrose (HFHS) Fed Fabp4 Cre-ERK2 Knockout Mice

YUKI ISHINODA, YASUO IDO, MIDORI NOGUCHI, YUSUKE YUMITA, KAZUKI KAGAMI, AYUMU OSAKI, YASUSHI SATOH, SHOGO ENDO, AKIRA KASUGA, TAKESHI ADACHI, HIROO KUMAGAI

Diabetes 2021;70(Supplement_1):1210-P

DOI: https://doi.org/10.2337/db21-1210-P

Published: 01 June 2021

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Meeting Abstracts

1823-P: Bromocriptine (BC) Normalizes Elevated Expression of Liver Genes Involved in Fatty Acid Oxidation, Lipogenesis, Inflammation, and Endoplasmic Reticulum (ER) Stress and Glucose Intolerance of High-Fat/Sucrose Diet-Fed Rats

YAHONG ZHANG, MICHAEL EZROKHI, NICHOLAS COMINOS, ANTHONY H. CINCOTTA

Diabetes 2020;69(Supplement_1):1823-P

DOI: https://doi.org/10.2337/db20-1823-P

Published: 01 June 2020

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Meeting Abstracts

1818-P: High-Sucrose Diet Causes Increased Hepatic Histone Acetylation Due to Increased Bacterial Acetate Production and Reduced Lipogenesis in ChREPB-Deficient Mice

KATSUMI IIZUKA, KEN TAKAO, YANYAN LIU, KENTA NONOMURA, TAKEHIRO KATO, MASAMI MIZUNO, YUKIO HORIKAWA, DAISUKE YABE

Diabetes 2020;69(Supplement_1):1818-P

DOI: https://doi.org/10.2337/db20-1818-P

Published: 01 June 2020

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Meeting Abstracts

5-LB: Consuming High-Fructose Corn Syrup or Sucrose-Sweetened Beverages Increases Hepatic Lipid Content and Decreases Insulin Sensitivity in Young Adults

DESIREE SIGALA, BETTINA HIERONIMUS, CANDICE PRICE, VIVIEN LEE, MARINELLE NUNEZ, VALENTINA MEDICI, ABHIJIT J. CHAUDHARI, JOHN P. MCGAHAN, YASSER ABDELHAFEZ, NANCY L. KEIM, MICHAEL I. GORAN, GIOVANNI PACINI, ANDREA TURA, PETER J. HAVEL, KIMBER L. STANHOPE

Diabetes 2020;69(Supplement_1):5-LB

DOI: https://doi.org/10.2337/db20-5-LB

Published: 01 June 2020

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Meeting Abstracts

290-LB: Repeated Neonatal Oral Sucrose Treatment Affects Growth and Insulin-Like Growth Factor-1 in Mice

CYNTHIA YAMILKA RAMIREZ CONTRERAS, EI-XIA MUSSAI, ALEJANDRA M. WIEDEMAN, ARYA MEHRAN, MELODY SALEHZADEH, NICHA BOONPATTRAWONG, MANON RANGER, KIRAN K. SOMA, LIISA HOLSTI, ANGELA M. DEVLIN

Diabetes 2019;68(Supplement_1):290-LB

DOI: https://doi.org/10.2337/db19-290-LB

Published: 01 June 2019

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Meeting Abstracts

774-P: Not Carbohydrate but Sucrose Intake Is Associated with Gut Dysbiosis in Japanese Patients with Type 2 Diabetes

YOSHITAKA HASHIMOTO, MASAHIDE HAMAGUCHI, AYUMI KAJI, RYOSUKE SAKAI, RYO INOUE, SAORI KASHIWAGI, KATSURA MIZUSHIMA, KAZUHIKO UCHIYAMA, TOMOHISA TAKAGI, YUJI NAITO, MICHIAKI FUKUI

Diabetes 2019;68(Supplement_1):774-P

DOI: https://doi.org/10.2337/db19-774-P

Published: 01 June 2019

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Meeting Abstracts

Effects of Sucrose vs. Fructose-and-Glucose Intakes on Gut Abundance of Akkermansia Muciniphila and Serum Kidney Injury Molecule-1 in Rats

GRZEGORZ WYSTRYCHOWSKI, EWA PIKULSKA-CHROBAK, JAKUB WOJCIK, MAGDALENA KOZUBSKA, WANDA TRAUTSOLT, SYLWIA GORCZYNSKA-KOSIORZ, ROMAN KUźNIEWICZ, EWA ZUKOWSKA-SZCZECHOWSKA, WLADYSLAW GRZESZCZAK, ANTONI WYSTRYCHOWSKI

Diabetes 2018;67(Supplement_1):1896-P

DOI: https://doi.org/10.2337/db18-1896-P

Published: 01 July 2018

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Meeting Abstracts

Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes

IRENA MARKOVÁ, MARTINA HÜTTL, HANA MALINSKA, ONDREJ SEDA, LUDMILA KAZDOVA

Diabetes 2018;67(Supplement_1):1723-P

DOI: https://doi.org/10.2337/db18-1723-P

Published: 01 July 2018

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Meeting Abstracts

The Different Effect of Sucrose on Transcriptomic Profile in Adipose and Muscle Tissues in Model of Metabolic Syndrome and Insulin Resistance

MARTINA HÜTTL, IRENA MARKOVÁ, HANA MALINSKA, LUDMILA KAZDOVA, ONDREJ SEDA

Diabetes 2018;67(Supplement_1):1722-P

DOI: https://doi.org/10.2337/db18-1722-P

Published: 01 July 2018

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Meeting Abstracts

Vitamin E Supplementation during Nonalcoholic Steatohepatitis (NASH) Pathogenesis in High-Sucrose, High-Fat-Fed Genetically Obese Mice

CLINTON HASENOUR, JAMEY YOUNG

Diabetes 2018;67(Supplement_1):257-LB

DOI: https://doi.org/10.2337/db18-257-LB

Published: 01 July 2018

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Meeting Abstracts

Next Generation of Spontaneous Diabetic Model of Fatzo Mice with Intact Leptin Signaling Develop Nephropathy after High-Fat and High-Sucrose Induction

GAO SUN, GUODONG ZHANG, YIXIN WANG

Diabetes 2018;67(Supplement_1):2195-PUB

DOI: https://doi.org/10.2337/db18-2195-PUB

Published: 01 July 2018

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Journal Articles

Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans

Jie Li, Bin Feng, Yaohui Nie, Ping Jiao, Xiaochen Lin, Mengna Huang, Ran An, Qin He, Huilin Emily Zhou, Arthur Salomon, Kirsten S. Sigrist, Zhidan Wu, Simin Liu, Haiyan Xu

Diabetes 2018;67(3):400–411

DOI: https://doi.org/10.2337/db17-0745

Published: 03 January 2018

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Includes: Supplementary data

Journal Articles

Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D₂ Receptor Binding and Age in Obesity

Marta Y. Pepino, Sarah A. Eisenstein, Allison N. Bischoff, Samuel Klein, Stephen M. Moerlein, Joel S. Perlmutter, Kevin J. Black, Tamara Hershey

Diabetes 2016;65(9):2618–2623

DOI: https://doi.org/10.2337/db16-0407

Published: 15 June 2016

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Journal Articles

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function

David W. Scoville, Holly A. Cyphert, Lan Liao, Jianming Xu, Al Reynolds, Shuangli Guo, Roland Stein

Diabetes 2015;64(11):3772–3783

DOI: https://doi.org/10.2337/db15-0281

Published: 15 July 2015

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Includes: Supplementary data

Journal Articles

Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

Guillaume Vial, Marie-Agnès Chauvin, Nadia Bendridi, Annie Durand, Emmanuelle Meugnier, Anne-Marie Madec, Nathalie Bernoud-Hubac, Jean-Paul Pais de Barros, Éric Fontaine, Cécile Acquaviva, Sophie Hallakou-Bozec, Sébastien Bolze, Hubert Vidal, Jennifer Rieusset

Diabetes 2015;64(6):2254–2264

DOI: https://doi.org/10.2337/db14-1220

Published: 31 December 2014

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Includes: Supplementary data

Journal Articles

TGFβ Receptor Signaling Is Essential for Inflammation-Induced but Not β-Cell Workload–Induced β-Cell Proliferation

Xiangwei Xiao, John Wiersch, Yousef El-Gohary, Ping Guo, Krishna Prasadan, Jose Paredes, Carey Welsh, Chiyo Shiota, George K. Gittes

Diabetes 2013;62(4):1217–1226

DOI: https://doi.org/10.2337/db12-1428

Published: 14 March 2013

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Includes: Supplementary data

Journal Articles

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

Cristina Carvalho, Susana Cardoso, Sónia C. Correia, Renato X. Santos, Maria S. Santos, Inês Baldeiras, Catarina R. Oliveira, Paula I. Moreira

Diabetes 2012;61(5):1234–1242

DOI: https://doi.org/10.2337/db11-1186

Published: 13 April 2012

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Includes: Supplementary data

Journal Articles

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Wan Huang, Anantha Metlakunta, Nikolaos Dedousis, Pili Zhang, Ian Sipula, John J. Dube, Donald K. Scott, Robert M. O'Doherty

Diabetes 2010;59(2):347–357

DOI: https://doi.org/10.2337/db09-0016

Published: 23 November 2009

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Includes: Supplementary data

Journal Articles

Impaired Glucose-Stimulated Insulin Secretion Is Coupled With Exocrine Pancreatic Lesions in the Cohen Diabetic Rat

Sarah Weksler-Zangen, Itamar Raz, Sigurd Lenzen, Anne Jörns, Shira Ehrenfeld, Gail Amir, Andrei Oprescu, Yoram Yagil, Chana Yagil, David H. Zangen, Nurit Kaiser

Diabetes 2008;57(2):279–287

DOI: https://doi.org/10.2337/db07-0520

Published: 01 February 2008

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Includes: Supplementary data

NARROW

1369-P: The Differential Effects of Estrogen on Determinants of Skeletal Muscle Bioenergetics with a High-Fat, High-Sucrose Diet in Rats

1210-P: Subcutaneous-Depot Specific Adiposity Change Is Associated with the Ectopic Fat Depot and Tissue Damage in High-Fat High-Sucrose (HFHS) Fed Fabp4 Cre-ERK2 Knockout Mice

1823-P: Bromocriptine (BC) Normalizes Elevated Expression of Liver Genes Involved in Fatty Acid Oxidation, Lipogenesis, Inflammation, and Endoplasmic Reticulum (ER) Stress and Glucose Intolerance of High-Fat/Sucrose Diet-Fed Rats

1818-P: High-Sucrose Diet Causes Increased Hepatic Histone Acetylation Due to Increased Bacterial Acetate Production and Reduced Lipogenesis in ChREPB-Deficient Mice

5-LB: Consuming High-Fructose Corn Syrup or Sucrose-Sweetened Beverages Increases Hepatic Lipid Content and Decreases Insulin Sensitivity in Young Adults

290-LB: Repeated Neonatal Oral Sucrose Treatment Affects Growth and Insulin-Like Growth Factor-1 in Mice

774-P: Not Carbohydrate but Sucrose Intake Is Associated with Gut Dysbiosis in Japanese Patients with Type 2 Diabetes

Effects of Sucrose vs. Fructose-and-Glucose Intakes on Gut Abundance of Akkermansia Muciniphila and Serum Kidney Injury Molecule-1 in Rats

Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes

The Different Effect of Sucrose on Transcriptomic Profile in Adipose and Muscle Tissues in Model of Metabolic Syndrome and Insulin Resistance

Vitamin E Supplementation during Nonalcoholic Steatohepatitis (NASH) Pathogenesis in High-Sucrose, High-Fat-Fed Genetically Obese Mice

Next Generation of Spontaneous Diabetic Model of Fatzo Mice with Intact Leptin Signaling Develop Nephropathy after High-Fat and High-Sucrose Induction

Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans

Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D₂ Receptor Binding and Age in Obesity

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function

Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

TGFβ Receptor Signaling Is Essential for Inflammation-Induced but Not β-Cell Workload–Induced β-Cell Proliferation

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Impaired Glucose-Stimulated Insulin Secretion Is Coupled With Exocrine Pancreatic Lesions in the Cohen Diabetic Rat

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