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Meeting Abstracts

241-LB: Positive Regulation of JAK/STAT at Signaling with SOCS3-Derived Cell-Permeable Binding Domain to ObR Induces Anti-obesity Effect

KUYSOOK LEE, JISOOK JEON, SU JEONG KIM, HYEONTAE KANG, JEONGHUN KWAK, YOUNGSIL CHOI, DAEWOONG JO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):241-LB
https://doi.org/10.2337/db20-241-LB
Published: 01 June 2020
View article titled, 241-LB: Positive Regulation of JAK/STAT at Signaling with SOCS3-Derived Cell-Permeable Binding Domain to ObR Induces Anti-obesity Effect
Meeting Abstracts

209-LB: Truncated SOCS3 Overcomes Insulin Resistance Associated With Type 2 Diabetes

JISOOK JEON, KUYSOOK LEE, SU JEONG KIM, HYEONTAE KANG, JEONGHUN KWAK, YOUNGSIL CHOI, DAEWOONG JO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):209-LB
https://doi.org/10.2337/db20-209-LB
Published: 01 June 2020
View article titled, 209-LB: Truncated SOCS3 Overcomes Insulin Resistance Associated With Type 2 Diabetes
Meeting Abstracts

1568-P: One Methylation Risk Score Model, Two Racial Populations

BRE A. MINNIEFIELD, MARGUERITE IRVIN, BERTHA HIDALGO, HEMANT K. TIWARI, AMIT PATKI, NINAD CHAUDHARY
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1568-P
https://doi.org/10.2337/db20-1568-P
Published: 01 June 2020
View article titled, 1568-P: One Methylation Risk Score Model, Two Racial Populations
Meeting Abstracts

309-LB: Cell-Permeable Truncated SOCS3 Competitively Inhibits the Interaction Between Endogenous SOCS3 and Leptin Receptor (ObR) to Overcome Leptin Resistance on JAK/STAT Signaling

KUYSOOK LEE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):309-LB
https://doi.org/10.2337/db19-309-LB
Published: 01 June 2019
View article titled, 309-LB: Cell-Permeable Truncated SOCS3 Competitively Inhibits the Interaction Between Endogenous SOCS3 and Leptin Receptor (ObR) to Overcome Leptin Resistance on JAK/STAT Signaling
Meeting Abstracts

310-LB: Intracellular Protein Therapy with Truncated SOCS3 Suppresses Obesity

KUYSOOK LEE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):310-LB
https://doi.org/10.2337/db19-310-LB
Published: 01 June 2019
View article titled, 310-LB: Intracellular Protein Therapy with Truncated SOCS3 Suppresses Obesity
Meeting Abstracts

1910-P: SOCS3 Deficiency on a High-Fat Diet Accelerates Systemic Inflammation and Results in Lethal Myeloid Hematopoiesis without Obesity and Adiposity

KAORI CHO, TAKASHI USHIKI, HAJIME ISHIGURO, TAKAYUKI KATAGIRI, TATSUYA SUWABE, HIDEYO HIRAI, YOSHIMI NAKAGAWA, MASAYOSHI MASUKO, WARREN ALEXANDER, HITOSHI SHIMANO, HIROHITO SONE
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1910-P
https://doi.org/10.2337/db19-1910-P
Published: 01 June 2019
View article titled, 1910-P: SOCS3 Deficiency on a High-Fat Diet Accelerates Systemic Inflammation and Results in Lethal Myeloid Hematopoiesis without Obesity and Adiposity
Journal Articles

Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance

Jonas Benzler, Goutham K. Ganjam, Dominik Pretz, Rebecca Oelkrug, Christiane E. Koch, Karen Legler, Sigrid Stöhr, Carsten Culmsee, Lynda M. Williams, Alexander Tups
Journal: Diabetes
Diabetes 2015;64(6):2015–2027
https://doi.org/10.2337/db14-0093
Published: 27 January 2015
View article titled, Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance
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Includes: Supplementary data
Journal Articles

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Sebastian Beck Jorgensen, Hayley M. O’Neill, Lykke Sylow, Jane Honeyman, Kimberly A. Hewitt, Rengasamy Palanivel, Morgan D. Fullerton, Lisa Öberg, Anudharan Balendran, Sandra Galic, Chris van der Poel, Ian A. Trounce, Gordon S. Lynch, Jonathan D. Schertzer, Gregory R. Steinberg
Journal: Diabetes
Diabetes 2013;62(1):56–64
https://doi.org/10.2337/db12-0443
Published: 13 December 2012
View article titled, Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
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Includes: Supplementary data
Journal Articles

Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes

Lucía Serrano-Marco, Ricardo Rodríguez-Calvo, Ilhem El Kochairi, Xavier Palomer, Liliane Michalik, Walter Wahli, Manuel Vázquez-Carrera
Journal: Diabetes
Diabetes 2011;60(7):1990–1999
https://doi.org/10.2337/db10-0704
Published: 20 June 2011
View article titled, Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes
Open the PDF for Activation of Peroxisome Proliferator–Activated Receptor-β/-δ (PPAR-β/-δ) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6–Stimulated Adipocytes in another window
Journal Articles

Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance

Nadege Briancon, David E. McNay, Eleftheria Maratos-Flier, Jeffrey S. Flier
Journal: Diabetes
Diabetes 2010;59(12):3074–3084
https://doi.org/10.2337/db10-0481
Published: 28 September 2010
View article titled, Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance
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Includes: Supplementary data
Journal Articles

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Alison S. Reed, Elizabeth K. Unger, Louise E. Olofsson, Merisa L. Piper, Martin G. Myers, Jr, Allison W. Xu
Journal: Diabetes
Diabetes 2010;59(4):894–906
https://doi.org/10.2337/db09-1024
Published: 12 January 2010
View article titled, Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis
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Includes: Supplementary data
Journal Articles

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

Hwi Jin Ko, Zhiyou Zhang, Dae Young Jung, John Y. Jun, Zhexi Ma, Kelly E. Jones, Sook Y. Chan, Jason K. Kim
Journal: Diabetes
Diabetes 2009;58(11):2536–2546
https://doi.org/10.2337/db08-1361
Published: 18 August 2009
View article titled, Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
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Journal Articles

Suppressors of Cytokine-Signaling Proteins Induce Insulin Resistance in the Retina and Promote Survival of Retinal Cells

Xuebin Liu, Marie G. Mameza, Yun Sang Lee, Chikezie I. Eseonu, Cheng-Rong Yu, Jennifer J. Kang Derwent, Charles E. Egwuagu
Journal: Diabetes
Diabetes 2008;57(6):1651–1658
https://doi.org/10.2337/db07-1761
Published: 01 June 2008
View article titled, Suppressors of Cytokine-Signaling Proteins Induce Insulin Resistance in the Retina and Promote Survival of Retinal Cells
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Includes: Supplementary data
Journal Articles

Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression: Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression

Yukiko Kanatani, Isao Usui, Ken Ishizuka, Agussalim Bukhari, Shiho Fujisaka, Masaharu Urakaze, Tetsuro Haruta, Tadamitsu Kishimoto, Tetsuji Naka, Masashi Kobayashi
Journal: Diabetes
Diabetes 2007;56(3):795–803
https://doi.org/10.2337/db06-1039
Published: 01 March 2007
View article titled, Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression: <subtitle>Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression</subtitle>
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Journal Articles

Diabetes and Suppressors of Cytokine Signaling Proteins

Sif G. Rønn, Nils Billestrup, Thomas Mandrup-Poulsen
Journal: Diabetes
Diabetes 2007;56(2):541–548
https://doi.org/10.2337/db06-1068
Published: 01 February 2007
View article titled, Diabetes and Suppressors of Cytokine Signaling Proteins
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Journal Articles

Nutritional Supplementation With trans-10, cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue

Hélène Poirier, Jennifer S. Shapiro, Roy J. Kim, Mitchell A. Lazar
Journal: Diabetes
Diabetes 2006;55(6):1634–1641
https://doi.org/10.2337/db06-0036
Published: 01 June 2006
View article titled, Nutritional Supplementation With <em>trans</em>-10, <em>cis</em>-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue
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Journal Articles

Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance

Hang Shi, Belinda Cave, Karen Inouye, Christian Bjørbæk, Jeffrey S. Flier
Journal: Diabetes
Diabetes 2006;55(3):699–707
https://doi.org/10.2337/diabetes.55.03.06.db05-0841
Published: 01 March 2006
View article titled, Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance
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Journal Articles

Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic β-Cells

Katharina Laubner, Timothy J. Kieffer, Ni T. Lam, Xinjie Niu, Franz Jakob, Jochen Seufert
Journal: Diabetes
Diabetes 2005;54(12):3410–3417
https://doi.org/10.2337/diabetes.54.12.3410
Published: 01 December 2005
View article titled, Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic β-Cells
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Journal Articles

The Potential Role of SOCS-3 in the Interleukin-1β-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

Brice Emanuelli, Murielle Glondu, Chantal Filloux, Pascal Peraldi, Emmanuel Van Obberghen
Journal: Diabetes
Diabetes 2004;53(suppl_3):S97–S103
https://doi.org/10.2337/diabetes.53.suppl_3.S97
Published: 01 December 2004
View article titled, The Potential Role of SOCS-3 in the Interleukin-1β-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells
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Journal Articles

Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients

Jennifer Rieusset, Karim Bouzakri, Emmanuel Chevillotte, Nadège Ricard, Delphine Jacquet, Jean-Philippe Bastard, Martine Laville, Hubert Vidal
Journal: Diabetes
Diabetes 2004;53(9):2232–2241
https://doi.org/10.2337/diabetes.53.9.2232
Published: 01 September 2004
View article titled, Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients
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