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Journal Articles

Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects

Anita C. Hohenstein, Joylynn Gallegos, Mylinh Dang, Jason Groegler, Hali Broncucia, Fatima Tensun, Kathleen Waugh, Fran Dong, Eddie A. James, Cate Speake, Andrea K. Steck, Marian J. Rewers, Peter A. Gottlieb, Kathryn Haskins, Thomas Delong, Rocky L. Baker
Journal: Diabetes
Diabetes db240611
https://doi.org/10.2337/db24-0611
Published: 16 January 2025
View article titled, Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects
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Journal Articles

Selective Reduction of Ca2+-Independent Phospholipase A2β (iPLA2β)-Derived Lipid Signaling From Macrophages Mitigates Type 1 Diabetes Development

Abdulaziz Almutairi, Tayleur D. White, Daniel J. Stephenson, Benjamin D. Stephenson, Ying Gai-Tusing, Paran Goel, Daniel W. Phillips, Robert S. Welner, Xiaoyong Lei, Bruce D. Hammock, Charles E. Chalfant, Sasanka Ramanadham
Journal: Diabetes
Diabetes 2024;73(12):2022–2033
https://doi.org/10.2337/db23-0770
Published: 16 September 2024
View article titled, Selective Reduction of Ca<sup>2+</sup>-Independent Phospholipase A<sub>2</sub>β (iPLA<sub>2</sub>β)-Derived Lipid Signaling From Macrophages Mitigates Type 1 Diabetes Development
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Journal Articles

Role of Peptidyl Arginine Deiminase 4–Dependent Macrophage Extracellular Trap Formation in Type 1 Diabetes Pathogenesis

Yiming Shen, Ruiya Shi, ShiPing Lu, Yan Wang, Ziqi Zhou, Chenhua Wu, Qi You, Hongye Fan, Jie Wu
Journal: Diabetes
Diabetes 2024;73(11):1862–1874
https://doi.org/10.2337/db23-1000
Published: 13 August 2024
View article titled, Role of Peptidyl Arginine Deiminase 4–Dependent Macrophage Extracellular Trap Formation in Type 1 Diabetes Pathogenesis
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Journal Articles

Temporal Alterations in CD8+ T Cells During the Progression From Stage 1 to Stage 3 Type 1 Diabetes

Anna-Mari Schroderus, Viola Pitkänen, Ilse Ekman, Daniella Stevens, Marja Rytkönen-Nissinen, Reeta Rintamäki, Jussi Pihlajamäki, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Tuure Kinnunen
Journal: Diabetes
Diabetes 2024;73(10):1705–1715
https://doi.org/10.2337/db24-0159
Published: 05 July 2024
View article titled, Temporal Alterations in CD8<sup>+</sup> T Cells During the Progression From Stage 1 to Stage 3 Type 1 Diabetes
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Journal Articles

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Journal: Diabetes
Diabetes 2024;73(5):728–742
https://doi.org/10.2337/db23-0588
Published: 22 February 2024
View article titled, CD4<sup>+</sup> T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets
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Journal Articles

An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes

Aïsha Callebaut, Perrin Guyer, Rocky L. Baker, Joylynn B. Gallegos, Anita C. Hohenstein, Peter A. Gottlieb, Chantal Mathieu, Lut Overbergh, Kathryn Haskins, Eddie A. James
Journal: Diabetes
Diabetes 2024;73(5):743–750
https://doi.org/10.2337/db23-0622
Published: 31 January 2024
View article titled, An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes
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Journal Articles

Excess Salt Intake Activates IL-21–Dominant Autoimmune Diabetogenesis via a Salt-Regulated Ste20-Related Proline/Alanine-Rich Kinase in CD4 T Cells

Jing-Jie Ciou, Ming-Wei Chien, Chao-Yuan Hsu, Yu-Wen Liu, Jia-Ling Dong, Shin-Ying Tsai, Sung-Sen Yang, Shih-Hua Lin, B. Lin-Ju Yen, Shin-Huei Fu, Huey-Kang Sytwu
Journal: Diabetes
Diabetes 2024;73(4):592–603
https://doi.org/10.2337/db23-0599
Published: 19 January 2024
View article titled, Excess Salt Intake Activates IL-21–Dominant Autoimmune Diabetogenesis via a Salt-Regulated Ste20-Related Proline/Alanine-Rich Kinase in CD4 T Cells
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Journal Articles

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

Puchong Thirawatananond, Matthew E. Brown, Lindsey K. Sachs, Juan M. Arnoletti, Wen-I Yeh, Amanda L. Posgai, Melanie R. Shapiro, Yi-Guang Chen, Todd M. Brusko
Journal: Diabetes
Diabetes 2023;72(11):1629–1640
https://doi.org/10.2337/db23-0307
Published: 25 August 2023
View article titled, Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
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Journal Articles

Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment

Carmen Fotino, R. Damaris Molano, Moufida Ben Nasr, Oliver Umland, Christopher A. Fraker, Ulisse Ulissi, Hari Baskar Balasubramanian, Maria Elena Lunati, Vera Usuelli, Andy Joe Seelam, Salma Ayman Khalefa, Christian La Sala, Jennifer Gimeno, Armando J. Mendez, Camillo Ricordi, Allison L. Bayer, Paolo Fiorina, Antonello Pileggi
Journal: Diabetes
Diabetes 2023;72(11):1641–1651
https://doi.org/10.2337/db23-0178
Published: 25 August 2023
View article titled, Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment
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Meeting Abstracts

1488-P: Reduced iPLA2b Expression in T-Lymphocytes Decreases Proinflammatory Eicosanoid Production and Cytokine Secretion Delaying Type 1 Diabetes Development in NOD Mice

TAYLEUR WHITE, SASANKA RAMANADHAM, TERESA P. DILORENZO, CHARLES E. CHALFANT
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1488-P
https://doi.org/10.2337/db23-1488-P
Published: 20 June 2023
View article titled, 1488-P: Reduced iPLA2b Expression in T-Lymphocytes Decreases Proinflammatory Eicosanoid Production and Cytokine Secretion Delaying Type 1 Diabetes Development in NOD Mice
Meeting Abstracts

295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction

JAMES E. DILISIO, ROCKY L. BAKER, KATHRYN M. HASKINS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):295-OR
https://doi.org/10.2337/db23-295-OR
Published: 20 June 2023
View article titled, 295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction
Meeting Abstracts

229-LB: Generation of Human CAR-Treg Cells for Inducing Immunological Tolerance against Diabetogenic T Cells in Human Pancreatic Islets

SHAHNAWAZ IMAM, SHAFIYA IMTIAZ RAFIQI, JUAN C. JAUME
Journal: Diabetes
Diabetes 2023;72(Supplement_1):229-LB
https://doi.org/10.2337/db23-229-LB
Published: 20 June 2023
View article titled, 229-LB: Generation of Human CAR-Treg Cells for Inducing Immunological Tolerance against Diabetogenic T Cells in Human Pancreatic Islets
Journal Articles

Protective Renalase Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes

Kevin Bode, Tara MacDonald, Taylor Stewart, Bryhan Mendez, Erica P. Cai, Noelle Morrow, Yu-Chi Lee, Peng Yi, Stephan Kissler
Journal: Diabetes
Diabetes 2023;72(8):1127–1143
https://doi.org/10.2337/db23-0030
Published: 22 May 2023
View article titled, Protective <em>Renalase</em> Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes
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Journal Articles

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Journal: Diabetes
Diabetes 2023;72(2):261–274
https://doi.org/10.2337/db22-0521
Published: 08 November 2022
View article titled, An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
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Journal Articles

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes

Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James
Journal: Diabetes
Diabetes 2023;72(1):85–96
https://doi.org/10.2337/db22-0191
Published: 06 October 2022
View article titled, Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes
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Journal Articles

Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Samantha A. Crawford, Timothy A. Wiles, Janet M. Wenzlau, Roger L. Powell, Gene Barbour, Mylinh Dang, Jason Groegler, Jessie M. Barra, KaLia S. Burnette, Anita C. Hohenstein, Rocky L. Baker, Hubert M. Tse, Kathryn Haskins, Thomas Delong
Journal: Diabetes
Diabetes 2022;71(12):2793–2803
https://doi.org/10.2337/db22-0303
Published: 30 August 2022
View article titled, Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes
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Journal Articles

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Journal: Diabetes
Diabetes 2022;71(8):1735–1745
https://doi.org/10.2337/db21-1069
Published: 21 August 2022
View article titled, Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes
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Journal Articles

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Roberto Mallone, Clémentine Halliez, Jinxiu Rui, Kevan C. Herold
Journal: Diabetes
Diabetes 2022;71(8):1603–1610
https://doi.org/10.2337/dbi21-0036
Published: 21 August 2022
View article titled, The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
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Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Journal Articles

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes
Journal: Diabetes
Diabetes 2022;71(9):1994–2008
https://doi.org/10.2337/db22-0177
Published: 17 June 2022
View article titled, Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
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