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Meeting Abstracts

290-OR: FoxK1-Associated Gene Regulatory Network—A New Transcriptional Regulator of Hepatic Insulin Action

PRASANNA ALLU, HUI PAN, JONATHAN DREYFUSS, C. RONALD KAHN

Diabetes 2023;72(Supplement_1):290-OR

https://doi.org/10.2337/db23-290-OR

Published: 20 June 2023

View article titled, 290-OR: FoxK1-Associated Gene Regulatory Network—A New Transcriptional Regulator of Hepatic Insulin Action

Meeting Abstracts

85-OR: Swi/Snf Controls Transcriptional Programs Required for ß-Cell Development and Postnatal Islet Function

REBECCA K. DAVIDSON, SUKRATI KANOJIA, MEREDITH E. OSMULSKI, JASON SPAETH

Diabetes 2023;72(Supplement_1):85-OR

https://doi.org/10.2337/db23-85-OR

Published: 20 June 2023

View article titled, 85-OR: Swi/Snf Controls Transcriptional Programs Required for ß-Cell Development and Postnatal Islet Function

Meeting Abstracts

284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

KAREN MENDEZ LARA, XIAOMI DU, KIMBERLY GLASS, RUBEN HERNANDEZ, CAMILA DE ARRUDA SALDANHA, SVEN HEINZ, AMIT R. MAJITHIA

Diabetes 2023;72(Supplement_1):284-OR

https://doi.org/10.2337/db23-284-OR

Published: 20 June 2023

View article titled, 284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

Journal Articles

β-Cell–Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion

Diabetes 2023;72(8):1112–1126

https://doi.org/10.2337/db22-0604

Published: 22 May 2023

View article titled, β-Cell–Specific <em>E2f1</em> Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion

Journal Articles

NRF2 and Diabetes: The Good, the Bad, and the Complex

Matthew Dodson, Aryatara Shakya, Annadurai Anandhan, Jinjing Chen, Joe G.N. Garcia, Donna D. Zhang

Diabetes 2022;71(12):2463–2476

https://doi.org/10.2337/db22-0623

Published: 21 November 2022

View article titled, NRF2 and Diabetes: The Good, the Bad, and the Complex

Journal Articles

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang

Diabetes 2023;72(2):261–274

https://doi.org/10.2337/db22-0521

Published: 08 November 2022

View article titled, An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Meeting Abstracts

250-LB: Tead1—A Regulator of Adult ß-Cell Proliferation and Function

JEONGKYUNG LEE, RUYA LIU, FENG LI, VINNY NEGI, RAJAGANAPATHI JAGANNATHAN, MARK HUISING, KE MA, BEN SHIH, MOUSUMI MOULIK, VIJAY YECHOOR

Diabetes 2022;71(Supplement_1):250-LB

https://doi.org/10.2337/db22-250-LB

Published: 01 June 2022

View article titled, 250-LB: Tead1—A Regulator of Adult ß-Cell Proliferation and Function

Meeting Abstracts

204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo

REBECCA K. DAVIDSON, NOLAN CASEY, SUKRATI KANOJIA, JASON SPAETH

Diabetes 2022;71(Supplement_1):204-OR

https://doi.org/10.2337/db22-204-OR

Published: 01 June 2022

View article titled, 204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo

Meeting Abstracts

1396-P: Critical Cellular Functions That Mediate the Early Stages of Adipogenesis Are Directly Influenced by 14-3-3zeta and Its Interactome

SABRI A. RIAL, AMAL ALKHOURY, GENEVIEVE LAVOIE, PHILIPPE ROUX, THOMAS M. DURCAN, AIDA MARTINEZ-SANCHEZ, GARETH E. LIM

Diabetes 2022;71(Supplement_1):1396-P

https://doi.org/10.2337/db22-1396-P

Published: 01 June 2022

View article titled, 1396-P: Critical Cellular Functions That Mediate the Early Stages of Adipogenesis Are Directly Influenced by 14-3-3zeta and Its Interactome

Meeting Abstracts

192-LB: Ductal Epithelial Cells Adopt Transcriptional Features of Tolerogenic Dendritic Cells in Type 1 Diabetes

KLAUS H. KAESTNER, HPAP CONSORTIUM, GOLNAZ VAHEDI

Diabetes 2022;71(Supplement_1):192-LB

https://doi.org/10.2337/db22-192-LB

Published: 01 June 2022

View article titled, 192-LB: Ductal Epithelial Cells Adopt Transcriptional Features of Tolerogenic Dendritic Cells in Type 1 Diabetes

Meeting Abstracts

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL

Diabetes 2022;71(Supplement_1):299-OR

https://doi.org/10.2337/db22-299-OR

Published: 01 June 2022

View article titled, 299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

Meeting Abstracts

1447-P: The Snd1 Coregulator Controls ß-Cell Function

SUKRATI KANOJIA, REBECCA K. DAVIDSON, JASON SPAETH, NOLAN CASEY

Diabetes 2022;71(Supplement_1):1447-P

https://doi.org/10.2337/db22-1447-P

Published: 01 June 2022

View article titled, 1447-P: The Snd1 Coregulator Controls ß-Cell Function

Meeting Abstracts

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

RANDY KANG, YANSUI LI, CAROLINA ROSSELOT, DONALD SCOTT, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2022;71(Supplement_1):1459-P

https://doi.org/10.2337/db22-1459-P

Published: 01 June 2022

View article titled, 1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

Meeting Abstracts

200-LB: Persistent cAMP Signaling Induces Adipocyte Browning through Biphasic Transcriptional and Epigenetic Remodeling

JISUN SO, SOLAEMA TALEB, JAMIE WANN, OLIVIA STROBEL, HYUN CHEOL ROH

Diabetes 2022;71(Supplement_1):200-LB

https://doi.org/10.2337/db22-200-LB

Published: 01 June 2022

View article titled, 200-LB: Persistent cAMP Signaling Induces Adipocyte Browning through Biphasic Transcriptional and Epigenetic Remodeling

Meeting Abstracts

179-OR: Defining Circadian Clock Dependency of Pancreatic Islet Transcriptional and Epigenetic Identity

MATTHEW BROWN, ALEKSEY MATVEYENKO

Diabetes 2021;70(Supplement_1):179-OR

https://doi.org/10.2337/db21-179-OR

Published: 01 June 2021

View article titled, 179-OR: Defining Circadian Clock Dependency of Pancreatic Islet Transcriptional and Epigenetic Identity

Meeting Abstracts

1247-P: The SND1 Coregulator Controls ß-Cell Function and Identity

SUKRATI KANOJIA, REBECCA K. DAVIDSON, NOLAN CASEY, JASON SPAETH

Diabetes 2021;70(Supplement_1):1247-P

https://doi.org/10.2337/db21-1247-P

Published: 01 June 2021

View article titled, 1247-P: The SND1 Coregulator Controls ß-Cell Function and Identity

Meeting Abstracts

178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

TRACY K. HER, MATTHEW BROWN, ALEKSEY MATVEYENKO, NAUREEN JAVEED

Diabetes 2021;70(Supplement_1):178-OR

https://doi.org/10.2337/db21-178-OR

Published: 01 June 2021

View article titled, 178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

Meeting Abstracts

261-OR: Transcriptional Profiling of the Intestinal Serotonin System in Individuals with Type 2 Diabetes and Healthy Individuals

CHRISTIAN LEGART, CHRISTOFFER A. HAGEMANN, ANNE MARIE ELLEGAARD, DAMIEN KEATING, TINA JORSAL, FILIP K. KNOP

Diabetes 2021;70(Supplement_1):261-OR

https://doi.org/10.2337/db21-261-OR

Published: 01 June 2021

View article titled, 261-OR: Transcriptional Profiling of the Intestinal Serotonin System in Individuals with Type 2 Diabetes and Healthy Individuals

Meeting Abstracts

248-OR: Type 1 Diabetes Risk Variants Alter the Transcriptional Profile of Beta Cells

WIKTORIA RATAJCZAK, SARAH ATKINSON, CATRIONA KELLY

Diabetes 2021;70(Supplement_1):248-OR

https://doi.org/10.2337/db21-248-OR

Published: 01 June 2021

View article titled, 248-OR: Type 1 Diabetes Risk Variants Alter the Transcriptional Profile of Beta Cells

Meeting Abstracts

395-P: Identification of Key Genes and Transcriptional Factors Associated with Podocyte Functions in Human Diabetic Nephropathy

AMMIRA S. AKIL, SUJITHA SUBASH PADMAJEYA, KHALID FAKHRO, TANWIR HABIB

Diabetes 2021;70(Supplement_1):395-P

https://doi.org/10.2337/db21-395-P

Published: 01 June 2021

View article titled, 395-P: Identification of Key Genes and Transcriptional Factors Associated with Podocyte Functions in Human Diabetic Nephropathy

NARROW

290-OR: FoxK1-Associated Gene Regulatory Network—A New Transcriptional Regulator of Hepatic Insulin Action

85-OR: Swi/Snf Controls Transcriptional Programs Required for ß-Cell Development and Postnatal Islet Function

284-OR: An Alternative Downstream Translational Start Site in PPARG Produces a Novel Protein That Rescues Loss-of-Function Mutations in Humans

β-Cell–Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion

NRF2 and Diabetes: The Good, the Bad, and the Complex

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

250-LB: Tead1—A Regulator of Adult ß-Cell Proliferation and Function

204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo

1396-P: Critical Cellular Functions That Mediate the Early Stages of Adipogenesis Are Directly Influenced by 14-3-3zeta and Its Interactome

192-LB: Ductal Epithelial Cells Adopt Transcriptional Features of Tolerogenic Dendritic Cells in Type 1 Diabetes

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

1447-P: The Snd1 Coregulator Controls ß-Cell Function

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

200-LB: Persistent cAMP Signaling Induces Adipocyte Browning through Biphasic Transcriptional and Epigenetic Remodeling

179-OR: Defining Circadian Clock Dependency of Pancreatic Islet Transcriptional and Epigenetic Identity

1247-P: The SND1 Coregulator Controls ß-Cell Function and Identity

178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

261-OR: Transcriptional Profiling of the Intestinal Serotonin System in Individuals with Type 2 Diabetes and Healthy Individuals

248-OR: Type 1 Diabetes Risk Variants Alter the Transcriptional Profile of Beta Cells

395-P: Identification of Key Genes and Transcriptional Factors Associated with Podocyte Functions in Human Diabetic Nephropathy

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