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Journal Articles

Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: Possible Mechanism for the GIP Resistance in Type 2 Diabetes

Dhananjay Gupta, Mina Peshavaria, Navjot Monga, Thomas L. Jetton, Jack L. Leahy
Journal: Diabetes
Diabetes 2010;59(6):1445–1450
https://doi.org/10.2337/db09-1655
Published: 23 March 2010
View article titled, Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: <subtitle>Possible Mechanism for the GIP Resistance in Type 2 Diabetes</subtitle>
Open the PDF for Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in β-Cells by Peroxisome Proliferator–Activated Receptor (PPAR)-γ Signaling: <subtitle>Possible Mechanism for the GIP Resistance in Type 2 Diabetes</subtitle> in another window
Includes: Supplementary data
Journal Articles

Extension of Type 2 Diabetes Genome-Wide Association Scan Results in the Diabetes Prevention Program

Allan F. Moore, Kathleen A. Jablonski, Jarred B. McAteer, Richa Saxena, Toni I. Pollin, Paul W. Franks, Robert L. Hanson, Alan R. Shuldiner, William C. Knowler, David Altshuler, Jose C. Florez, for the Diabetes Prevention Program Research Group
Journal: Diabetes
Diabetes 2008;57(9):2503–2510
https://doi.org/10.2337/db08-0284
Published: 01 September 2008
View article titled, Extension of Type 2 Diabetes Genome-Wide Association Scan Results in the Diabetes Prevention Program
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Includes: Supplementary data
Journal Articles

Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes

Kyu Lee Han, Joo Sun Choi, Jae Young Lee, Jihyun Song, Myung Kuk Joe, Myeong Ho Jung, Jae-Kwan Hwang
Journal: Diabetes
Diabetes 2008;57(3):737–745
https://doi.org/10.2337/db07-0972
Published: 01 March 2008
View article titled, Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes
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Includes: Supplementary data
Journal Articles

Peroxisome Proliferator–Activated Receptor-γ Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells

Jacob A. Moibi, Dhananjay Gupta, Thomas L. Jetton, Mina Peshavaria, Ronak Desai, Jack L. Leahy
Journal: Diabetes
Diabetes 2007;56(1):88–95
https://doi.org/10.2337/db06-0948
Published: 01 January 2007
View article titled, Peroxisome Proliferator–Activated Receptor-γ Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells
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Journal Articles

Effect of Pioglitazone on Pancreatic β-Cell Function and Diabetes Risk in Hispanic Women With Prior Gestational Diabetes

Anny H. Xiang, Ruth K. Peters, Siri L. Kjos, Aura Marroquin, Jose Goico, Cesar Ochoa, Miwa Kawakubo, Thomas A. Buchanan
Journal: Diabetes
Diabetes 2006;55(2):517–522
https://doi.org/10.2337/diabetes.55.02.06.db05-1066
Published: 01 February 2006
View article titled, Effect of Pioglitazone on Pancreatic β-Cell Function and Diabetes Risk in Hispanic Women With Prior Gestational Diabetes
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Journal Articles

Sequence Variation in PPARG May Underlie Differential Response to Troglitazone

Johanna K. Wolford, Kimberly A. Yeatts, Sharanjeet K. Dhanjal, Mary Helen Black, Anny H. Xiang, Thomas A. Buchanan, Richard M. Watanabe
Journal: Diabetes
Diabetes 2005;54(11):3319–3325
https://doi.org/10.2337/diabetes.54.11.3319
Published: 01 November 2005
View article titled, Sequence Variation in <em>PPARG</em> May Underlie Differential Response to Troglitazone
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Journal Articles

Prevention of Type 2 Diabetes With Troglitazone in the Diabetes Prevention Program

The Diabetes Prevention Program Research Group*
Journal: Diabetes
Diabetes 2005;54(4):1150–1156
https://doi.org/10.2337/diabetes.54.4.1150
Published: 01 April 2005
View article titled, Prevention of Type 2 Diabetes With Troglitazone in the Diabetes Prevention Program
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Journal Articles

Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ

So-youn Kim, Ha-il Kim, Sang-Kyu Park, Seung-Soon Im, Tianzhu Li, Hyae Gyeong Cheon, Yong-ho Ahn
Journal: Diabetes
Diabetes 2004;53(suppl_1):S66–S70
https://doi.org/10.2337/diabetes.53.2007.S66
Published: 01 February 2004
View article titled, Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ
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Journal Articles

Deleterious Effects of Acute Treatment With a Peroxisome Proliferator–Activated Receptor-γ Activator in Myocardial Ischemia and Reperfusion in Pigs

Ya Xu, Li Lu, Clifford Greyson, Jenny Lee, Michael Gen, Koichiro Kinugawa, Carlin S. Long, Gregory G. Schwartz
Journal: Diabetes
Diabetes 2003;52(5):1187–1194
https://doi.org/10.2337/diabetes.52.5.1187
Published: 01 May 2003
View article titled, Deleterious Effects of Acute Treatment With a Peroxisome Proliferator–Activated Receptor-γ Activator in Myocardial Ischemia and Reperfusion in Pigs
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Journal Articles

Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy

Susan A. Phillips, Theodore P. Ciaraldi, Alice P.S. Kong, Rahil Bandukwala, Vanita Aroda, Leslie Carter, Sunita Baxi, Sunder R. Mudaliar, Robert R. Henry
Journal: Diabetes
Diabetes 2003;52(3):667–674
https://doi.org/10.2337/diabetes.52.3.667
Published: 01 March 2003
View article titled, Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
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Journal Articles

Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy

John M. Miles, David Wooldridge, Wayne J. Grellner, Sheryl Windsor, William L. Isley, Samuel Klein, William S. Harris
Journal: Diabetes
Diabetes 2003;52(3):675–681
https://doi.org/10.2337/diabetes.52.3.675
Published: 01 March 2003
View article titled, Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: <subtitle>Effects of Insulin Sensitization Therapy </subtitle>
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Journal Articles

Troglitazone Antagonizes Metabolic Effects of Glucocorticoids in Humans: Effects on Glucose Tolerance, Insulin Sensitivity, Suppression of Free Fatty Acids, and Leptin

Steven M. Willi, Adele Kennedy, Penny Wallace, Elizabeth Ganaway, Nikki L. Rogers, W. Timothy Garvey
Journal: Diabetes
Diabetes 2002;51(10):2895–2902
https://doi.org/10.2337/diabetes.51.10.2895
Published: 01 October 2002
View article titled, Troglitazone Antagonizes Metabolic Effects of Glucocorticoids in Humans: <subtitle>Effects on Glucose Tolerance, Insulin Sensitivity, Suppression of Free Fatty Acids, and Leptin </subtitle>
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Journal Articles

Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes

Marco M. Meyer, Klaus Levin, Thomas Grimmsmann, Nina Perwitz, Alexandra Eirich, Henning Beck-Nielsen, Harald H. Klein
Journal: Diabetes
Diabetes 2002;51(9):2691–2697
https://doi.org/10.2337/diabetes.51.9.2691
Published: 01 September 2002
View article titled, Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes
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Journal Articles

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Thomas A. Buchanan, Anny H. Xiang, Ruth K. Peters, Siri L. Kjos, Aura Marroquin, Jose Goico, Cesar Ochoa, Sylvia Tan, Kathleen Berkowitz, Howard N. Hodis, Stanley P. Azen
Journal: Diabetes
Diabetes 2002;51(9):2796–2803
https://doi.org/10.2337/diabetes.51.9.2796
Published: 01 September 2002
View article titled, Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women
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Journal Articles

Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures

Hans Günther Wahl, Christiana Kausch, Fausto Machicao, Kristian Rett, Michael Stumvoll, Hans-Ulrich Häring
Journal: Diabetes
Diabetes 2002;51(4):1060–1065
https://doi.org/10.2337/diabetes.51.4.1060
Published: 01 April 2002
View article titled, Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures
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Journal Articles

Peroxisomal Proliferator-Activated Receptor-γ Upregulates Glucokinase Gene Expression in β-Cells

Ha-il Kim, Ji-Young Cha, So-Youn Kim, Jae-woo Kim, Kyung Jin Roh, Je-Kyung Seong, Nam Taek Lee, Kang-Yell Choi, Kyung-Sup Kim, Yong-ho Ahn
Journal: Diabetes
Diabetes 2002;51(3):676–685
https://doi.org/10.2337/diabetes.51.3.676
Published: 01 March 2002
View article titled, Peroxisomal Proliferator-Activated Receptor-γ Upregulates Glucokinase Gene Expression in β-Cells
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Journal Articles

Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects

Young-Bum Kim, Theodore P. Ciaraldi, Alice Kong, Dennis Kim, Neelima Chu, Pharis Mohideen, Sunder Mudaliar, Robert R. Henry, Barbara B. Kahn
Journal: Diabetes
Diabetes 2002;51(2):443–448
https://doi.org/10.2337/diabetes.51.2.443
Published: 01 February 2002
View article titled, Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects
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Journal Articles

Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects

Theodore P. Ciaraldi, Alice P.S. Kong, Neelima V. Chu, Dennis D. Kim, Sunita Baxi, Mattias Loviscach, Ray Plodkowski, Richard Reitz, Michael Caulfield, Sunder Mudaliar, Robert R. Henry
Journal: Diabetes
Diabetes 2002;51(1):30–36
https://doi.org/10.2337/diabetes.51.1.30
Published: 01 January 2002
View article titled, Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects
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Journal Articles

Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor-γ−Mediated Changes in Gene Expression

Barbara Brunmair, Florian Gras, Susanne Neschen, Michael Roden, Ludwig Wagner, Werner Waldhäusl, Clemens Fürnsinn
Journal: Diabetes
Diabetes 2001;50(10):2309–2315
https://doi.org/10.2337/diabetes.50.10.2309
Published: 01 October 2001
View article titled, Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor-γ−Mediated Changes in Gene Expression
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Journal Articles

Troglitazone Not Only Increases GLUT4 but Also Induces Its Translocation in Rat Adipocytes

Mitsuyo Shintani, Haruo Nishimura, Shin Yonemitsu, Yoshihiro Ogawa, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, Kazuwa Nakao
Journal: Diabetes
Diabetes 2001;50(10):2296–2300
https://doi.org/10.2337/diabetes.50.10.2296
Published: 01 October 2001
View article titled, Troglitazone Not Only Increases GLUT4 but Also Induces Its Translocation in Rat Adipocytes
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