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Journal Articles

The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium–Glucose Transporter 2 Inhibitors

Mayumi Yamato, Nao Kato, Ken-ichi Yamada, Toyoshi Inoguchi
Journal: Diabetes
Diabetes 2024;73(7):1153–1166
https://doi.org/10.2337/db22-0970
Published: 12 April 2024
View article titled, The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium–Glucose Transporter 2 Inhibitors
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Journal Articles

Blocking Hemopexin With Specific Antibodies: A New Strategy for Treating Diabetic Retinopathy

Patricia Bogdanov, Anna Duarri, David Sabater, Anna Salas, Helena Isla-Magrané, Hugo Ramos, Jordi Huerta, Marta Valeri, José García-Arumí, Rafael Simó, Cristina Hernández
Journal: Diabetes
Diabetes 2023;72(12):1841–1852
https://doi.org/10.2337/db23-0027
Published: 18 September 2023
View article titled, Blocking Hemopexin With Specific Antibodies: A New Strategy for Treating Diabetic Retinopathy
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Meeting Abstracts

1491-P: ER Stress Drives the VEGF Expression in Monocytic Cells by Mechanisms Involving CHOP/ROS/HIF-1alpha/NRF2 and NF-kappaB/p38 MAPK Pathways

SARDAR A.K. SINDHU, NADEEM AKHTER, AJIT WILSON, HOSSEIN AREFANIAN, ASHRAF AL MADHOUN, REEBY S. THOMAS, SHIHAB P. KOCHUMON, FATEMA ALRASHED, FATEMAH BAHMAN, FAWAZ ALZAID, FAHD ALMULLA, RASHEED AHMAD
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1491-P
https://doi.org/10.2337/db23-1491-P
Published: 20 June 2023
View article titled, 1491-P: ER Stress Drives the VEGF Expression in Monocytic Cells by Mechanisms Involving CHOP/ROS/HIF-1alpha/NRF2 and NF-kappaB/p38 MAPK Pathways
Meeting Abstracts

324-OR: VEGF Is a Contributing Factor for the Reduction of Retinal Function in Diabetic Retinopathy and Hypoxic Retinal Disorders

YUN LE, MEILI ZHU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):324-OR
https://doi.org/10.2337/db23-324-OR
Published: 20 June 2023
View article titled, 324-OR: VEGF Is a Contributing Factor for the Reduction of Retinal Function in Diabetic Retinopathy and Hypoxic Retinal Disorders
Journal Articles

Cytochrome-Derived EETs, VEGF-A, and NOX4: Piecing the Puzzle Together

Karin Jandeleit-Dahm, Jaroslawna Meister
Journal: Diabetes
Diabetes 2023;72(7):841–843
https://doi.org/10.2337/dbi23-0006
Published: 20 June 2023
View article titled, Cytochrome-Derived EETs, VEGF-A, and NOX4: Piecing the Puzzle Together
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Journal Articles

Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy

Stavroula Dionysopoulou, Per Wikstrom, Claudio Bucolo, Giovanni Luca Romano, Vincenzo Micale, Richard Svensson, Dimitris Spyridakos, Niki Mastrodimou, Spiros Georgakis, Panayotis Verginis, Erik Walum, Kyriaki Thermos
Journal: Diabetes
Diabetes 2023;72(5):638–652
https://doi.org/10.2337/db22-0515
Published: 23 February 2023
View article titled, Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
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Journal Articles

VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease

Rachel Njeim, Kawthar Braych, Hilda E. Ghadieh, Nadim S. Azar, William S. Azar, Batoul Dia, Angelo Leone, Francesco Cappello, Hala Kfoury, Frederic Harb, Abdo R. Jurjus, Assaad A. Eid, Fuad N. Ziyadeh
Journal: Diabetes
Diabetes 2023;72(7):947–957
https://doi.org/10.2337/db22-0636
Published: 20 January 2023
View article titled, VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease
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Journal Articles

Identifying Hyperreflective Foci in Diabetic Retinopathy via VEGF-Induced Local Self-Renewal of CX3CR1+ Vitreous Resident Macrophages

Muneo Yamaguchi, Shintaro Nakao, Iori Wada, Tetsuya Matoba, Mitsuru Arima, Yoshihiro Kaizu, Mariko Shirane, Keijiro Ishikawa, Takahito Nakama, Yusuke Murakami, Masaharu Mizuochi, Wataru Shiraishi, Ryo Yamasaki, Toshio Hisatomi, Tatsuro Ishibashi, Masabumi Shibuya, Alan W. Stitt, Koh-Hei Sonoda
Journal: Diabetes
Diabetes 2022;71(12):2685–2701
https://doi.org/10.2337/db21-0247
Published: 07 October 2022
View article titled, Identifying Hyperreflective Foci in Diabetic Retinopathy via VEGF-Induced Local Self-Renewal of CX3CR1<sup>+</sup> Vitreous Resident Macrophages
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Meeting Abstracts

24-OR: Podocyte Targeted Pyruvate Kinase M2 (PKM2) Activation Normalized Glomerular VEGF Expression, Mitochondrial Function, Fuel Metabolism, and Diabetic Nephropathy

JIALIN FU, TAKANORI SHINJO, QIAN LI, KYOUNGMIN PARK, MARC GREGORY YU, HISASHI YOKOMIZO, QIAN HUANG, I-HSIEN WU, GEORGE L. KING
Journal: Diabetes
Diabetes 2022;71(Supplement_1):24-OR
https://doi.org/10.2337/db22-24-OR
Published: 01 June 2022
View article titled, 24-OR: Podocyte Targeted Pyruvate Kinase M2 (PKM2) Activation Normalized Glomerular VEGF Expression, Mitochondrial Function, Fuel Metabolism, and Diabetic Nephropathy
Meeting Abstracts

484-P: Uncoupling of IL-1beta and VEGF-A Signaling Axis Contributes to Impaired Arteriogenesis in the Context of Aging and Diabetes Mellitus

CHRIS S. MANTSOUNGA, SHEILA SHARMA, CADENCE LEE, RACHEL CARLEY, GAURAV CHOUDHARY, ALAN R. MORRISON
Journal: Diabetes
Diabetes 2022;71(Supplement_1):484-P
https://doi.org/10.2337/db22-484-P
Published: 01 June 2022
View article titled, 484-P: Uncoupling of IL-1beta and VEGF-A Signaling Axis Contributes to Impaired Arteriogenesis in the Context of Aging and Diabetes Mellitus
Journal Articles

Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy

Yashika Rustagi, Ahmed S. Abouhashem, Priyanka Verma, Sumit S. Verma, Edward Hernandez, Sheng Liu, Manishekhar Kumar, Poornachander R. Guda, Rajneesh Srivastava, Sujit K. Mohanty, Sedat Kacar, Sanskruti Mahajan, Kristen E. Wanczyk, Savita Khanna, Michael P. Murphy, Gayle M. Gordillo, Sashwati Roy, Jun Wan, Chandan K. Sen, Kanhaiya Singh
Journal: Diabetes
Diabetes 2022;71(5):1149–1165
https://doi.org/10.2337/db21-0830
Published: 22 February 2022
View article titled, Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy
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Journal Articles

GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression

Vanessa Königs, Sandra Pierre, Martin Schicht, Jessica Welss, Lisa Hahnefeld, Vittoria Rimola, Elke Lütjen-Drecoll, Gerd Geisslinger, Klaus Scholich
Journal: Diabetes
Diabetes 2022;71(4):774–787
https://doi.org/10.2337/db21-0711
Published: 21 January 2022
View article titled, GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression
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Meeting Abstracts

89-OR: Cardiovascular and Mortality Risk with Intravitreal Anti-Vascular Endothelial Growth Factor (VEGF) Inhibitors in Patients with Diabetic Retinopathy (DR)

MIIN ROH, HELEN TESFAYE, LLOYD P. AIELLO, SEOYOUNG C. KIM, ELISABETTA PATORNO
Journal: Diabetes
Diabetes 2021;70(Supplement_1):89-OR
https://doi.org/10.2337/db21-89-OR
Published: 01 June 2021
View article titled, 89-OR: Cardiovascular and Mortality Risk with Intravitreal Anti-Vascular Endothelial Growth Factor (VEGF) Inhibitors in Patients with Diabetic Retinopathy (DR)
Journal Articles

Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy

Priyamvada M. Pitale, Irina V. Saltykova, Yvonne Adu-Agyeiwaah, Sergio Li Calzi, Takashi Satoh, Shizuo Akira, Oleg Gorbatyuk, Michael E. Boulton, Machelle T. Pardue, W. Timothy Garvey, Mohammad Athar, Maria B. Grant, Marina S. Gorbatyuk
Journal: Diabetes
Diabetes 2021;70(8):1738–1753
https://doi.org/10.2337/db20-1268
Published: 11 May 2021
View article titled, Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy
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Journal Articles

Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes

Andreia Goncalves, Alyssa Dreffs, Cheng-mao Lin, Sarah Sheskey, Natalie Hudson, Jason Keil, Matthew Campbell, David A. Antonetti
Journal: Diabetes
Diabetes 2021;70(7):1549–1560
https://doi.org/10.2337/db20-1220
Published: 21 April 2021
View article titled, Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes
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Journal Articles

Endothelial Cells Derived From Patients With Diabetic Macular Edema Recapitulate Clinical Evaluations of Anti-VEGF Responsiveness Through the Neuronal Pentraxin 2 Pathway

Marta Vilà González, Magdalini Eleftheriadou, Sophia Kelaini, Hojjat Naderi-Meshkin, Shonagh Flanagan, Stephen Stewart, Gianni Virgili, David J. Grieve, Alan W. Stitt, Noemi Lois, Andriana Margariti
Journal: Diabetes
Diabetes 2020;69(10):2170–2185
https://doi.org/10.2337/db19-1068
Published: 13 August 2020
View article titled, Endothelial Cells Derived From Patients With Diabetic Macular Edema Recapitulate Clinical Evaluations of Anti-VEGF Responsiveness Through the Neuronal Pentraxin 2 Pathway
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Meeting Abstracts

326-OR: Faricimab for Diabetic Macular Edema: A Novel Anti–Angiopoietin-2/Anti–Vascular Endothelial Growth Factor Bispecific Antibody in Clinical Trials

VEERAL SHETH, JAYASHREE SAHNI, IVAYLO STOILOV, JEFFREY R. WILLIS, ROBERT WEIKERT
Journal: Diabetes
Diabetes 2020;69(Supplement_1):326-OR
https://doi.org/10.2337/db20-326-OR
Published: 01 June 2020
View article titled, 326-OR: Faricimab for Diabetic Macular Edema: A Novel Anti–Angiopoietin-2/Anti–Vascular Endothelial Growth Factor Bispecific Antibody in Clinical Trials
Meeting Abstracts

591-P: Macrophage IL-1beta–Dependent VEGF-A Expression Is Required for Inflammatory Arteriogenesis and Wound Healing in Type 2 Diabetes

CHRIS S. MANTSOUNGA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):591-P
https://doi.org/10.2337/db20-591-P
Published: 01 June 2020
View article titled, 591-P: Macrophage IL-1beta–Dependent VEGF-A Expression Is Required for Inflammatory Arteriogenesis and Wound Healing in Type 2 Diabetes
Meeting Abstracts

605-P: Endothelial-Specific Overexpression of Metallothionein Prevents Diabetes Mellitus–Induced Impairment in Ischemia Angiogenesis via Preservation of HIF-1a/SDF-1/VEGF Signaling in Endothelial Progenitor Cells

KAI WANG, XIAOZHEN DAI, JING CHEN, FEIXIA SHEN, KUPPER A. WINTERGERST, PAUL N. EPSTEIN, LU CAI, YI TAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):605-P
https://doi.org/10.2337/db20-605-P
Published: 01 June 2020
View article titled, 605-P: Endothelial-Specific Overexpression of Metallothionein Prevents Diabetes Mellitus–Induced Impairment in Ischemia Angiogenesis via Preservation of HIF-1a/SDF-1/VEGF Signaling in Endothelial Progenitor Cells
Journal Articles

Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells

Kai Wang, Xiaozhen Dai, Junhong He, Xiaoqing Yan, Chengkui Yang, Xia Fan, Shiyue Sun, Jing Chen, Jianxiang Xu, Zhongbin Deng, Jiawei Fan, Xiaohuan Yuan, Hairong Liu, Edward C. Carlson, Feixia Shen, Kupper A. Wintergerst, Daniel J. Conklin, Paul N. Epstein, Chaosheng Lu, Yi Tan
Journal: Diabetes
Diabetes 2020;69(8):1779–1792
https://doi.org/10.2337/db19-0829
Published: 13 May 2020
View article titled, Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells
Open the PDF for Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells in another window