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8-ohdg-8-hydroxydeoxyguanosine

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Journal Articles
Journal: Diabetes
Diabetes 2001;50(12):2837–2841
Published: 01 December 2001
...Kyong Soo Park; Jae Hyeon Kim; Min Seon Kim; Jeong Mi Kim; Suk Kyeong Kim; Jeong Yun Choi; Myung Hee Chung; Boghee Han; Seong Yeon Kim; Hong Kye Lee Cumulating evidence suggests that enhanced oxidative stress may contribute to diabetic angiopathy. The levels of 8-hydroxydeoxyguanosine (8-OHdG...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(11):2795–2804
Published: 01 November 2003
... stress and apoptosis in endothelial cells, have been evaluated. Stable high glucose increased nitrotyrosine, 8-hydroxydeoxyguanosine (8-OHdG), and apoptosis levels. However, these effects were more pronounced in intermittent high glucose. Protein kinase C (PKC) was elevated in both such conditions...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(4):809–816
Published: 01 April 2008
..., with DNA damage, type 2 diabetes, and CVD. RESEARCH DESIGN AND METHODS— We measured DNA damage as urinary 8-hydroxydeoxyguanosine (8-OHdG) concentration and examined the relationship between nine PPARGC1A genetic variants, DNA damage, type 2 diabetes, and self-reported CVD in 959 participants...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1109-P
Published: 01 June 2020
... Chromatography-Mass Spectrometry. Plasmatic cGMP level, a marker of NO production and urinary 8-hydroxydeoxyguanosine (8-OHdG) level, a marker of oxidative stress, were measured. Results: The urinary level of L-arginine was higher in ZSF-1 rats compared to CTR ones, and plasmatic concentrations of L-arginine...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(10):2603–2614
Published: 01 October 2003
... of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan. E-mail: haneda@belle.shiga-med.ac.jp 14 7 2003 13 3 2003 DIABETES 2003 8-OHdG, 8-hydroxydeoxyguanosine DPI, diphenylene iodonium GFP, green fluorescent protein l-NMMA, NG-monomethyl...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(11):3112–3120
Published: 01 November 2006
... 11 8 2006 30 6 2006 DIABETES 2006 8-OHdG, 8-hydroxydeoxyguanosine AGE, advanced glycation end product CTGF, connective tissue growth factor DAG, diacylglycerol ET-1, endothelin-1 FF, filtration fraction GFR, glomerular filtration rate PAH, para-aminohippurate PKC, protein...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(5):1588–1595
Published: 01 May 2002
... mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a 4,834-bp deletion in kidney of streptozotocin-induced diabetic rats. At 8 weeks after the onset of diabetes, levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is a marker of oxidative DNA damage, were significantly increased in mtDNA from...
Journal Articles
Journal: Diabetes
Diabetes 2013;62(10):3582–3588
Published: 17 September 2013
... stress marker, 8-hydroxydeoxyguanosine (8-OHdG), which binds to oxidized DNA. The untreated rats exhibited intense cytoplasmic staining of 4-HNE in β-cells [ Fig. 4A(a) ], which was virtually absent in ebselen-treated rats [ Fig. 4A(b) ], indicating that ebselen had...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(12):3233–3238
Published: 01 December 2004
... on retinal 8-hydroxy-2′deoxyguanosine (8-OHdG) and nitrotyrosine levels was determined by enzyme-linked immunosorbent assay. α-Lipoic acid administration for the entire duration of diabetes inhibited capillary cell apoptosis and the number of acellular capillaries in the retina, despite similar severity...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(11):2995–3005
Published: 17 October 2011
...). DNA oxidative damage in the retina was determined with the oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG). Briefly, the sections of retina were blocked with goat serum, and the monoclonal antibody 8-OHdG (Japan Institute for Control of Ageing, Japan) was added overnight followed...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2016;65(7):1849–1857
Published: 19 April 2016
...) ( 27 ). Circulating FGF21, fetuin A, selenoprotein P (SepP), and high-molecular-weight adiponectin were determined by ELISA ( 13 , 27 ). Peroxidation of endogenous lipids and nucleic acid oxidation were assessed from thiobarbituric acid reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2012;61(Supplement_1):A522–A548
Published: 01 June 2012
..., pancreas weighed, pancreatic beta cell mass quan- PORTHA, JAMILEH MOVASSAT, Paris, France ti ed, and the amount of islet brosis determined. Urinary and pancreatic islet 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, was Although highly specialized, the pancreatic beta cells retain...
Meeting Abstracts
Journal: Diabetes
Diabetes 2012;61(Supplement_1):A443–A522
Published: 01 June 2012
..., oxidative stress in islets was evaluated by immunostaining controls under chow diet (129S6/SvEvTac average age at death: 23.5±5.0 of 8-hydroxy-deoxyguanosine (8-OHdG). Staining intensities of 8-OHdG was month and C57BL/6NTac 21.1±4 month). The permanent high caloric diet increased in maternal HFD only...