... Pischon Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological pathways and help to identify individuals at risk for disease. We prospectively investigated the association between serum metabolites measured by targeted metabolomics and risk of T2D in the European...

...   1969 ; 281 : 811 – 816 5809519 62. Floegel   A , Stefan   N , Yu   Z , et al . Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639 – 648 23043162 63. Menni   C , Fauman   E...

... associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639 – 648 14. Shah   SH , Svetkey   LP , Newgard   CB . Branching out for detection of type 2 diabetes . Cell Metab   2011 ; 13 : 491 – 492 21531330 15. Barber   MN , Risis...

...-aged men and women . Diabetes Care   2012 ; 35 : 1749 – 1756 22563043 12. Floegel   A , Stefan   N , Yu   Z , et al . Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes 2013;62:639–647 23043162 13...

...” sciences but nevertheless serve to illustrate the potential power of integrated approaches for identification of novel metabolic regulatory networks that contribute to chronic disease such as type 2 diabetes. As targeted metabolic profiling methods evolve to encompass a larger set of metabolites...

... , Yu   Z , et al . Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639 – 648 20. Wang-Sattler   R , Yu   Z , Herder   C , et al . Novel biomarkers for pre-diabetes identified...

... prediction for early CKD in type 2 diabetes . Clin J Am Soc Nephrol   2015 ; 10 : 1371 – 1379 12. Floegel   A , Stefan   N , Yu   Z , et al . Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639...

... follow-up, and use of an untargeted and unbiased approach for serum metabolomic profiling of 1,136 metabolites that could maximize the potential for discovering novel metabolite signatures associated with incident diabetes ( 20 ). These study features represent an ideal opportunity to explore metabolic...

... of metformin using a nontargeted metabolomics approach. We analyzed 353 metabolites in fasting serum samples of the population-based human KORA (Cooperative Health Research in the Region of Augsburg) follow-up survey 4 cohort. To compare T2D patients treated with metformin (mt-T2D, n = 74) and those...

.... Fernandez-Garcia JC , Delpino-Rius A , Samarra I , . Type 2 diabetes is associated with a different pattern of serum polyamines: a case-control study from the PREDIMED-Plus trial . J Clin Med 2019 ; 8 : 71 37. Zhu X-R , Yang F-y , Lu J , . Plasma metabolomic...

..., 84 GC/MS metabolites not assayed through targeted approaches were used for data analysis. Batches of fasting and 1-h maternal serum sample pairs were constructed to balance field center, maternal glucose, and BMI and newborn outcomes across batches. Quality control pools were prepared with equal...

... to be defined. Applying a mass spectrometry–based nontargeted metabolomics approach, we report here alterations of 330 plasma metabolites representing 33 metabolic pathways during an 8-h insulin deprivation in type 1 diabetic individuals. These pathways included those known to be affected by insulin...

... that are valuable for facilitating the identification of novel biomarkers using multidisciplinary approaches. We applied multiple layers of analyses using publicly available data sets together with Wake Forest AA-DHS metabolomics data to illuminate how a potential DKD biomarker, AKR1A1, was identified. To our...

... analysis in type 2 diabetic patients and risk prediction for diabetic microangiopathy . J Clin Med   2019 ; 8 : 874 9. Theilade   S , Lajer   M , Hansen   TW , Rossing   P . Pulse wave reflection is associated with diabetes duration, albuminuria and cardiovascular disease in type 1...

... A , Stefan N , Yu Z , . Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes 2013 ; 62 : 639 – 648 17. Ferrannini E , Natali A , Camastra S , . Early metabolic markers of the development...

... associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639 – 648 23043162 20. Suhre   K , Meisinger   C , Döring   A , et al . Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting . PLoS One...

... patients is instrumental to tackle this burden. We investigated the association between serum metabolites and all-cause mortality in type 2 diabetes and then whether the associated metabolites mediate the effect of inflammation on mortality risk and improve ENFORCE (EstimatioN oF mORtality risk in type2...

... . Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639 – 648 23043162 10. McCormack   SE , Shaham   O , McCarthy   MA , et al . Circulating branched-chain amino acid concentrations are associated...

... metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach . Diabetes   2013 ; 62 : 639 – 648 7. Wang   TJ , Larson   MG , Vasan   RS , et al . Metabolite profiles and the risk of developing diabetes . Nat Med   2011 ; 17 : 448 – 453 8. Tabak   AG...

... complications rarely develop. It has therefore been suggested that GCK-MODY represents a metabolically compensated condition, but experimental support for this notion is lacking. Here, we profiled metabolites in serum from patients with MODY1 (HNF4A), MODY2 (GCK), MODY3 (HNF1A), and type 2 diabetes and from...