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aicar-5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

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Journal Articles
Journal: Diabetes
Diabetes 2001;50(1):12–17
Published: 01 January 2001
...Esben S. Buhl; Niels Jessen; Ole Schmitz; Steen B. Pedersen; Oluf Pedersen; Geoffrey D. Holman; Sten Lund Recent studies have demonstrated that chronic administration of AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), an activator of the AMP-activated protein kinase, increases...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(2):355–360
Published: 01 February 2005
...R. Richard Pencek; Jane Shearer; Raul C. Camacho; Freyja D. James; D. Brooks Lacy; Patrick T. Fueger; E. Patrick Donahue; Wanda Snead; David H. Wasserman The infusion of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) causes a rise in tissue concentrations of the AMP analog 5...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(5):1076–1082
Published: 01 May 2001
...Raynald Bergeron; Stephen F. Previs; Gary W. Cline; Pascale Perret; Raymond R. Russell III; Lawrence H. Young; Gerald I. Shulman Activation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) increases glucose transport in skeletal muscle...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(8):2078–2084
Published: 01 August 2007
... by exercise, metformin, 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), and adiponectin increases glucose uptake. The aim of this study was to determine whether AICAR stimulates muscle glucose uptake in humans. We studied 29 healthy men (aged 26 ± 8 years, BMI 25 ± 4 kg/m2...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(7):1649–1654
Published: 01 July 2004
... AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside AMPK, AMP-activated protein kinase FA, fatty acid HF rat, high-fat–fed rat LCACoA, long-chain acyl-CoA Recent evidence suggests that AMP-activated protein kinase (AMPK) is involved in mediating metabolic responses of muscle...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(1):41–50
Published: 01 January 2005
..., MI 48109-2214. E-mail: gcartee@umich.edu 4 10 2004 23 3 2004 AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside AS160, Akt substrate of 160 kDa KHB, Krebs-Henseleit buffer PAS, phospho-(Ser/Thr) Akt substrate PI, phosphatidylinositol TBST, Tris-buffered...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(7):2199–2206
Published: 01 July 2002
... by the adenosine analog 5-aminoimidazole-4-carboxamide-1-β -d-ribofuranoside (AICAR) has been shown to augment insulin action, upregulate mitochondrial enzymes in skeletal muscles, and decrease the content of intra-abdominal fat. Furthermore, acute AICAR exposure has been found to reduce sterol and fatty...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(7):1627–1634
Published: 01 July 2003
... adenosine analog 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) and the mitochondrial inhibitor oligomycin, similar to 4-Hz electrostimulation, evoked a more than threefold activation of cardiomyocytic AMP kinase. Both AICAR and oligomycin stimulated FA uptake into noncontracting...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(10):2886–2894
Published: 01 October 2002
... the effects of the AMPK activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) on insulin action in insulin-resistant high-fat-fed (HF) rats. Rats received a subcutaneous injection of 250 mg/kg AICAR (HF-AIC) or saline (HF-Con). The next day, euglycemic-hyperinsulinemic clamp studies...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(1):9–15
Published: 01 January 2003
..., in the absence of prior glycogen breakdown, glucose treatment failed to activate GS above control values, indicating the crucial role of glycogen content. Activation of AMPK by either 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR) or hydrogen peroxide was also associated with a decrease...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(1):64–76
Published: 01 January 2008
... and 85%) was assessed as the percentage of elongated cells with clear cross striations that excluded 0.2% trypan blue. To examine the influence of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) (an AMPK activator) and the serine protease thrombin (to activate p38 MAPK) on LPL...
Images
Whole-cell current clamp recordings in an OAE neuron in 2.5 mmol/l glucose ...
Published: 01 December 2006
FIG. 4. Whole-cell current clamp recordings in an OAE neuron in 2.5 mmol/l glucose in a hypothalamic slice from a 2- to 3-week-old rat. 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) reversed the excitatory effect of OA. FIG. 4. Whole-cell current clamp recordings in an OAE neuron in 2.5 mmol/l glucose in a hypothalamic slice from a 2- to 3-week-old rat. 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) reversed the excitatory effect of OA. More
Journal Articles
Journal: Diabetes
Diabetes 2006;55(6):1840–1846
Published: 01 June 2006
... (P < 0.05), using a luminol assay. Treatment with gAd for 16 h suppressed glucose-induced ROS in a dose-dependent manner up to 81% at 300 nmol/l (P < 0.05). The AMPK activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR; 1 mmol/l, 16 h) only partially decreased...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(4):865–874
Published: 01 April 2006
... is controlled by glucokinase. We report here that 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), metformin, and oligomycin activated AMPK and inhibited glucose phosphorylation and glycolysis in rat hepatocytes. In vitro experiments demonstrated that this inhibition was not due to direct...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2008;57(2):306–314
Published: 01 February 2008
... in hepatocytes, and metformin–and adenovirus SHP (Ad-SHP)–mediated hepatic glucose production was measured in B6-Lepob/ob mice. RESULTS —Hepatic SHP gene expression was induced by metformin, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), and Ad-AMPK...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2005;54(2):373–382
Published: 01 February 2005
...) during exercise. AMPK can be pharmacologically stimulated by 5-aminoimidazole-4-carboxamide-ribofuranoside (AICAR), which enters cells and is rapidly phosphorylated to 5-aminoimidazole-4-carboxamide-1-β-d-ribosyl-5-monophospate (ZMP) ( 10 ), an AMP analog. Administration of AICAR causes marked...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(3):617–623
Published: 01 March 2005
... is associated with an increase in G6P ( 32 ) and the effects of G6P on phosphorylase are counteracted by 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), which is metabolized to an AMP analog ( 13 ), we tested the separate and combined effects of glucokinase overexpression and AICAR...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(5):1414–1418
Published: 01 May 2008
... 31 10 2007 DIABETES 2008 ACC, acetyl-CoA carboxylase AICAR, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside AMPK, AMP-activated protein kinase BBR, berberine CAMKK, Ca2+/calmodulin-dependent protein kinase kinase dhBBR, dihydroberberine HFD, high-fat diet MEF...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2007;56(9):2228–2234
Published: 01 September 2007
...: moleyk@wustl.edu 8 6 2007 16 1 2007 DIABETES 2007 AICAR, 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside AMPK, AMP kinase DPCPX, 1,3-dipropyl-8-cyclopentylxanthine E, embryonic day hCG, human chorionic gonadotropin HTF, human tubal fluid IGFBP-1, IGF binding...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(4):1052–1059
Published: 01 April 2004
... requests to Clemens Fürnsinn, PhD, Department of Medicine III, Division of Endocrinology & Metabolism, Währinger Gürtel 18-20, A-1090 Vienna, Austria. E-mail: clemens.fuernsinn@akh-wien.ac.at 23 12 2003 14 10 2003 DIABETES 2004 AICAR, 5-aminoimidazole-4-carboxamide-1-β...