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alt-alanine-aminotransferase

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Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1105-P
Published: 01 June 2020
...) is common amongst those with type 2 diabetes (T2DM). Alanine aminotransferase (ALT) is known to correlate with levels of liver inflammation and fibrosis. Recent data from our audit programme showed promising reductions in ALT with dapagliflozin. Our aim was to test the same hypothesis, that canagliflozin...
Images
Schematic describing metabolism of selected amino acids and the related pro...
Published: 01 December 2006
FIG. 3. Schematic describing metabolism of selected amino acids and the related production of metabolic stimulus-secretion coupling factors involved in insulin release. The pathway of glutamine metabolism via glutaminase, GDH, and entry into the TCA cycle (glutaminolysis) is illustrated along with... More
Images
Plasma markers for organ function. <span class="search-highlight">Alanine</span> <span class="search-highlight">aminotransferase</span> (<span class="search-highlight">ALT</span>), aspartat...
Published: 01 April 2006
FIG. 4. Plasma markers for organ function. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and urea in plasma over time (A) and on day 7 (B). □, NI/NG (n = 8); ▵, HI/NG (n = 8); •, NI/HG (n = 9); ×, HI/HG (n = 8). **P < 0.0008 vs. NI/NG and HI/NG; *P < 0.05 vs. NI/NG and HI/NG; †P = 0.06 vs. NI/NG. FIG. 4. Plasma markers for organ function. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and urea in plasma over time (A) and on day 7 (B). □, NI/NG (n = 8); ▵, HI/NG (n = 8); •, NI/HG (n = 9); ×, HI/HG (n = 8). **P < 0.0008 vs. NI/NG and HI/NG; *P < 0.05 vs. NI/NG and HI/NG; †P = 0.06 vs. NI/NG. More
Journal Articles
Journal: Diabetes
Diabetes 1989;38(7):881–886
Published: 01 July 1989
... also inversely related to HbA1c. Vitamin B6 nutriture, as determined by erythrocyte aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, was normal in all diabetic subjects before vitamin B6 therapy. Nonetheless, HbA1c levels...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(11):2855–2860
Published: 01 November 2004
...Naveed Sattar; Olga Scherbakova; Ian Ford; Denis St. J. O’Reilly; Adrian Stanley; Ewan Forrest; Peter W. MacFarlane; Chris J. Packard; Stuart M. Cobbe; James Shepherd We examined the association of serum alanine aminotransferase (ALT) with features of the metabolic syndrome and whether it predicted...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(6):1889–1895
Published: 01 June 2002
... enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], or γ -glutamyltranspeptidase [GGT]) are associated with prospective changes in liver or whole-body insulin sensitivity and/or insulin secretion and whether these elevated enzymes predict the development of type 2 diabetes in Pima...
Images
Effects of pterosin A on serum levels of lipid, blood urea nitrogen (BUN), ...
Published: 17 January 2013
FIG. 3. Effects of pterosin A on serum levels of lipid, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in HFD-fed or STZ-induced diabetic mouse (DM) models. The HFD-feeding or STZ-induced diabetic mice were orally treated with pterosin A (100 mg/kg) for 4 weeks. Serum lipids (total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol) (A and B), BUN and creatinine (C), and AST and ALT (D) levels were measured in fasting mice. Data are presented as mean ± SEM (n = 8). *P < 0.05 vs. control. #P < 0.05 vs. STZ or HFD diabetic mice without pterosin A. FIG. 3. Effects of pterosin A on serum levels of lipid, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in HFD-fed or STZ-induced diabetic mouse (DM) models. The HFD-feeding or STZ-induced diabetic mice were orally treated with pterosin A (100 mg/kg) for 4 weeks. Serum lipids (total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol) (A and B), BUN and creatinine (C), and AST and ALT (D) levels were measured in fasting mice. Data are presented as mean ± SEM (n = 8). *P < 0.05 vs. control. #P < 0.05 vs. STZ or HFD diabetic mice without pterosin A. More
Journal Articles
Journal: Diabetes
Diabetes 2005;54(11):3140–3147
Published: 01 November 2005
... of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALK), predict the development of metabolic syndrome. Our objective was to investigate the associations of elevated AST, ALT, and other liver markers, including C-reactive protein (CRP), with incident National...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(10):2623–2632
Published: 01 October 2004
...) and alanine aminotransferase (ALT), with prospective risk of type 2 diabetes. However, only one study has adjusted for a detailed measure of insulin sensitivity (insulin sensitivity index [Si]), which is important given associations of obesity and Si with nonalcoholic...
Includes: Supplementary data
Images
Ngn3-Btc+PD-L1 reverses hyperglycemia and restores glucose tolerance. <ital
Published: 20 October 2014
Figure 1 Ngn3-Btc+PD-L1 reverses hyperglycemia and restores glucose tolerance. A and B: Blood glucose and body weight in diabetic NOD mice (Ngn3-Btc+PD-L1 group, n = 16; other groups, n = 4–7). C: Nonfasting plasma insulin at indicated time points (n = 4–8). D and E: Plasma aspartate aminotransferase (AST) (D) and alanine aminotransferase (ALT) (E) at the indicated time points (n = 4–6). FI: Plasma glucose and insulin during an intraperitoneal GTT at 4 weeks (F and G) and 8 weeks (H and I). Data are mean ± SEM. *P ≤ 0.05. Figure 1. Ngn3-Btc+PD-L1 reverses hyperglycemia and restores glucose tolerance. A and B: Blood glucose and body weight in diabetic NOD mice (Ngn3-Btc+PD-L1 group, n = 16; other groups, n = 4–7). C: Nonfasting plasma insulin at indicated time points (n = 4–8). D and E: Plasma aspartate aminotransferase (AST) (D) and alanine aminotransferase (ALT) (E) at the indicated time points (n = 4–6). F–I: Plasma glucose and insulin during an intraperitoneal GTT at 4 weeks (F and G) and 8 weeks (H and I). Data are mean ± SEM. *P ≤ 0.05. More
Journal Articles
Journal: Diabetes
Diabetes 2007;56(4):984–991
Published: 01 April 2007
... for age and treatment allocation. Eighteen months before the diagnosis, converters to diabetes had elevated (P < 0.01) fasting glucose, weight, triglyceride, alanine aminotransferase (ALT), blood pressure, and white cell count and lower HDL cholesterol compared with nonconverters. The mean (SD...
Images
PDK2 deficiency ameliorates hepatic steatosis in mice fed an HFD. Body weig...
Published: 06 July 2016
Figure 2 PDK2 deficiency ameliorates hepatic steatosis in mice fed an HFD. Body weight gain (n = 12) (A), liver/body weight ratio (n = 6) (B), and representative images of the livers (B) of WT and PDK2 KO mice fed an LFD or HFD. C: Representative histological appearance of H&E-stained liver and epididymal adipose tissue (EAT) obtained from the mice in A. Scale bars, 100 μm. Level of hepatic TG (D), hepatic glycogen (E), serum aspartate aminotransferase (AST) (E), and serum alanine aminotransferase (ALT) (F) activities in overnight-fasted WT and PDK2 KO mice (n = 6). Date are presented as the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. Figure 2. PDK2 deficiency ameliorates hepatic steatosis in mice fed an HFD. Body weight gain (n = 12) (A), liver/body weight ratio (n = 6) (B), and representative images of the livers (B) of WT and PDK2 KO mice fed an LFD or HFD. C: Representative histological appearance of H&E-stained liver and epididymal adipose tissue (EAT) obtained from the mice in A. Scale bars, 100 μm. Level of hepatic TG (D), hepatic glycogen (E), serum aspartate aminotransferase (AST) (E), and serum alanine aminotransferase (ALT) (F) activities in overnight-fasted WT and PDK2 KO mice (n = 6). Date are presented as the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. More
Images
G0S2 deficiency abolishes TG accumulation in liver. <em>A</em>: Hep...
Published: 13 February 2014
Figure 3 G0S2 deficiency abolishes TG accumulation in liver. A: Hepatic TG content in 16-h-fasted female mice fed chow diet (n = 8 per group) or HFD (n = 11 per group) for 14 weeks. ###P < 0.001 vs. WT chow; ***P < 0.001 vs. WT HFD. B: Representative image of liver from female mice after 14 weeks on HFD followed by a 16-h fast. C: Representative H-E staining of liver sections from mice in A. D and E: Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in mice after 14 weeks on chow diet or HFD starting at the age of 8 weeks (n = 5–8 per group for chow diet and 14–17 per group for HFD). **P < 0.01, ***P < 0.001 vs. WT HFD. U, units. Figure 3. G0S2 deficiency abolishes TG accumulation in liver. A: Hepatic TG content in 16-h-fasted female mice fed chow diet (n = 8 per group) or HFD (n = 11 per group) for 14 weeks. ###P < 0.001 vs. WT chow; ***P < 0.001 vs. WT HFD. B: Representative image of liver from female mice after 14 weeks on HFD followed by a 16-h fast. C: Representative H-E staining of liver sections from mice in A. D and E: Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in mice after 14 weeks on chow diet or HFD starting at the age of 8 weeks (n = 5–8 per group for chow diet and 14–17 per group for HFD). **P < 0.01, ***P < 0.001 vs. WT HFD. U, units. More
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1173-P
Published: 01 July 2018
... transaminases in the EMPA-REG OUTCOME trial. Patients with T2DM and established CV disease were randomized to receive EMPA 10 mg, EMPA 25 mg, or placebo (PBO) in addition to standard of care. Changes from baseline in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assessed in all...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1842-P
Published: 01 June 2020
... months. Aged mice fed GAN had rapid signs of liver damage: by 1 month, serum alanine aminotransferase (ALT) rose from 53 ± 20 to 309 ± 188 IU/L (Repeated measures ANOVA; P < 0.0001) and aspartate aminotransferase (AST) increased from 77 ± 33 to 399 ± 420 IU/L (P < 0.0001); values were stable...
Journal Articles
Journal: Diabetes
Diabetes 2019;68(8):1681–1691
Published: 14 May 2019
... causal relation between liver function and T2D risk including up to 64,094 T2D case and 607,012 control subjects. Several biomarkers were used as proxies of liver function (i.e., alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], and γ-glutamyl transferase [GGT...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2018;67(6):1086–1092
Published: 05 April 2018
... with GE Lunar iDXA version 15. ALT, alanine aminotransferase; GGT, γ-glutamyl transferase; IGT, impaired glucose tolerance; NA, not available; NAFLD, nonalcoholic fatty liver disease; PCOS, polycystic ovary syndrome; T2DM, type 2 diabetes mellitus. **Predicted body fat = (1.48 × BMI) − 7. ¶Yes...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1344-P
Published: 01 July 2018
... reductions in fat mass and increases in lean tissue mass. Blood glucose concentrations and glycated haemoglobin A1c (HbA1c) levels improved in all treatment arms, but lower HbA1c levels were found with liraglutide and metformin. Serum alanine aminotransferase (ALT) concentrations decreased in all treatment...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1076-P
Published: 01 June 2020
... at baseline and 3 months after ciclosporin A intervention. We also evaluated total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine (Cre) before and after ciclosporin A treatment. The primary outcome of the study was the change...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1147-P
Published: 01 June 2019
... parameters including total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine (Cre) before and after ciclosporin A treatment. The primary outcome of the study was the change in serum C-peptide concentrations. A total of 12 patients...