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brdu-bromodeoxyuridine

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Journal Articles
Journal: Diabetes
Diabetes 1994;43(11):1279–1283
Published: 01 November 1994
... expressed CKs 7, 19, and 20, particularly within a peripheral mantle zone that was continuous with the epithelium of adjacent ductules. This pattern was found during the first 2 weeks of life when significant islet growth occurred as determined by morphometry and bromodeoxyuridine (BrdU) labeling. Moreover...
Journal Articles
Journal: Diabetes
Diabetes 1997;46(4):599–606
Published: 01 April 1997
... the capacity of adult NOD mice for regeneration was investigated by evaluating islet neogenesis BrdU, bromodeoxyuridine; DAB, diaminobenzidine; IFN--y, y-interferon; in the ductal epithelium of diabetic NOD and age-matched IPF-I, insulin-promoter factor 1; NPY, neuropeptide Y; STZ, streptozotocin; nondiabetic...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(8):2035–2042
Published: 01 August 2003
... on the phenotype and location of β-stem cells remains scarce. Here, we provide evidence that β-stem cells are slow-cycling cells located within and around the islets of Langerhans. First, using a bromodeoxyuridine (BrdU) pulse/chase approach, we detected BrdU-retaining cells in vivo in the islet area of rat...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(12):3387–3394
Published: 01 December 2005
..., low insulin content, undetectable C-peptide release, and an inability to correct hyperglycemia. They exhibited a proliferative activity that was highest during posttransplant week 1 (2.6 and 5% bromodeoxyuridine [BrdU]-positive β-cells 4 and 72 h posttransplant) and then decreased over 20 weeks...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(8):863–870
Published: 01 August 1995
... requests to Dr. Roger H. Unger, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235-8854. 1 BrdU, bromodeoxyuridine; FACoA, fatty acyl CoA; FFA, free fatty acid; GSIS, glucose-stimulated insulin secretion; NIDDM, non-insulin-dependent diabetes mellitus...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1-LB
Published: 01 June 2020
... was assessed by injecting bromodeoxyuridine (BrdU) before sacrificing in several time-points across 24 h. The role of functional islet oscillators in b-cell regeneration was studies in clock deficient mice. Our data suggest that both absolute levels and diurnal profiles of blood glucose, insulin and glucagon...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):166-LB
Published: 01 June 2019
... with empagliflozin (Empa). Material and Methods: We examined the effects of Cana and Empa on 1) cell proliferation using colon cancer cell lines, SW480 and HCT116 by MTT assay, 2) DNA synthesis by flow cytometry-based analysis of bromodeoxyuridine (BrdU) uptake. We further examined 3) the expression of SGLT1 and 2...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(8):1108–1114
Published: 01 August 1996
... Pharma, Nether- BrdU, bromodeoxyuridine; BSA, bovine serum albumin; CK19, cytokeratin-19; CA19-9, carbohydrate antigen 19-9; 3D, three-dimensional; FCS, fetal calf serum; PBS, phosphate-buffered saline; RT, rat tail. 1108 DIABETES, VOL. 45, AUGUST 1996 J. KERR-CONTE AND ASSOCIATES lands). Islets were...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(8):2007–2015
Published: 01 August 2003
... 19 12 2002 DIABETES 2003 BrdU, bromodeoxyuridine CHIB, cultured human islet bud CK19, cytokeratin 19 FGF-7, fibroblast growth factor-7 NIC, nicotinamide PFA, paraformaldehyde Transplantation of isolated islets from cadaver pancreas is a promising possibility for the optimal...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(7):941–946
Published: 01 July 1996
..., a potent inhibitor of islet P-cell poly (ADP-ribose) February 1996. synthetase (10), prevented the diabetes, if any, caused by partial pancreatectomy in this model rat. BrdU, bromodeoxyuridine; LETO, Long-Evans-Tokushima-Otsuka; LI, labeling index; OLETF, Otsuka-Long-Evans-Tokushima Fatty; Px...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(5):1248–1258
Published: 01 May 2007
... hybridization was done as previously described ( 24 ). No signal was obtained when a sense riboprobe was used. BrdU, bromodeoxyuridine FGF10, fibroblast growth factor 10 INSERM, Institut National de la Santé et de la Recherche Médicale PDX1, pancreatic duodenal homeobox-1 Epithelium-mesenchyme...
Journal Articles
Journal: Diabetes
Diabetes 1998;47(8):1335–1340
Published: 01 August 1998
..., Lake Placid, NY), con- taining the cell binding (but not heparin I) domain; and 120-kDa chymotryptic (life BFGF, basic fibroblast growth factor; BrdU, bromodeoxyuridine; DMEM, Technologies), which spans a small portion of the collagen/gelatin binding Dulbecco's modified Eagle's medium; ECM...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(1):149–159
Published: 01 January 2004
...@msx.dept-med.pitt.edu 3 10 2003 20 5 2003 DIABETES 2004 BrdU, bromodeoxyuridine cdk, cyclin-dependent kinase DAB, 3,3′-diaminobenzidine-tetra-hydrochloride DMEM, Dulbecco’s modified Eagle’s medium GK, glucokinase GSIS, glucose-stimulated insulin secretion Kir6.2, K...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(4):909–917
Published: 01 April 2008
... BrdU, bromodeoxyuridine CTL, cytotoxic T-lymphocyte DC, dendritic cell FACS, fluorescence-activated cell sorter IFN, interferon PLN, pancreatic lymph node RIP, rat insulin promoter TNF, tumor necrosis factor Treg, T regulatory Chronic inflammation defines many organ-specific autoimmune...
Journal Articles
Journal: Diabetes
Diabetes 2009;58(3):663–672
Published: 01 March 2009
.... Intermediate glucose (8 mmol/l) produced a striking degree of synergism in combination with GSK-3 inhibition to enhance bromodeoxyuridine (BrdU) incorporation and Ki-67 expression in human β-cells. Nuclear translocation of β-catenin responsible for cell proliferation was found to be particularly sensitive...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(5):1235–1239
Published: 01 May 2003
... polyamine concentrations peaking after 24 h of diabetes. A subsequent increase in the number of proliferating proximal tubular cells was detected by in vivo 5-bromodeoxyuridine (BrdU) incorporation on day 3. Surprisingly, immunohistochemical studies revealed that increased ODC protein was apparent only...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(3):634–640
Published: 01 March 2007
... urinary glucose on two sequential occasions were considered diabetic and were then randomized to be given 5 μg/day i.v. for 5 consecutive days of either anti-CD3 or of normal hamster immunoglobulins. To identify proliferating cells, mice were given a single dose of bromodeoxyuridine (BrdU...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(4):722–730
Published: 01 April 1999
... cells at 13.5 dpc. BM, basement membrane; BrdU, bromodeoxyuridine; BSA, bovine serum albumin; dpc, days postcoitum; ECM, extracellular matrix; GAF, Gomori aldehyde fuchsin; MT, mouse tonicity; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PP, pancreatic polypeptide; RT, reverse...
Journal Articles
Journal: Diabetes
Diabetes 1997;46(7):1198–1206
Published: 01 July 1997
..., Endocrinology, and Metabolism Foundation, Largo Marchiafava 1, 00161 Rome, Italy. 1 AGE, advanced glycation end product; BrdU, bromodeoxyuridine; C-IV, collagen IV; D, diabetic; ECM, extracellular matrix; FN, fibronectin; KDDM, kidney disease of diabetes mellitus; MGV, mean glomerular volume; ND...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(8):2024–2033
Published: 01 August 2004
... Sarvetnick, PhD, Department of Immunology, IMM23, The Scripps Research Institute, La Jolla, CA 92037. E-mail: noras@scripps.edu 5 5 2004 16 3 2004 DIABETES 2004 BrdU, bromodeoxyuridine ICC, islet-like cell cluster IFN, interferon FITC, fluorescein isothiocyanate PCNA...