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cad-coronary-artery-disease

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Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):449-P
Published: 01 July 2018
... 0.67±0.98 1.18±1.06 0.20* *p for between-group difference in change from baseline to 7 years by ANCOVA Abbreviations: CAD: coronary artery disease, T2D: type 2 diabetes, MULTI: multi-intervention, STAND: standard care. Data given as mean±standard deviation. Disclosure A.P. Ofstad...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):450-P
Published: 01 June 2019
...KAZUYA FUJIHARA; YASUHIRO MATSUBAYASHI; MAYUKO HARADA; TAEKO OSAWA; MASAHIKO YAMAMOTO; MASARU KITAZAWA; MASANORI KANEKO; HIROYASU SEIDA; NAUTA YAMANAKA; SATORU KODAMA; HIROHITO SONE Although DM and prior CAD/CVD are established risk factors for subsequent CAD and CVD, which has the higher impact...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):448-P
Published: 01 June 2019
...MASARU KITAZAWA; KAZUYA FUJIHARA; TAEKO OSAWA; MASAHIKO YAMAMOTO; MAYUKO HARADA; MASANORI KANEKO; YASUHIRO MATSUBAYASHI; TAKAHO YAMADA; NAUTA YAMANAKA; HIROYASU SEIDA; WATARU OGAWA; HIROHITO SONE Although GTS, prior CAD and other traditional risk factors independently affect incidence of subsequent...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1488-P
Published: 01 July 2018
...MASARU KITAZAWA; KAZUYA FUJIHARA; MAYUKO HARADA; MASAHIRO ISHIZAWA; MASAHIKO YAMAMOTO; MASANORI KANEKO; TAEKO OSAWA; TAKAHO YAMADA; YASUHIRO MATSUBAYASHI; HIROHITO SONE Despite a decade of historical debate and the recent rebuttal regarding “diabetes mellitus (DM) as a CAD risk equivalent”, few...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):6-OR
Published: 01 June 2020
..., especially according to GTS, remain debatable. We analyzed data from a nationwide claims database on 293,396 participants without prior CAD or CVD from 2008-16. Multivariate Cox regression model identified risks of CAD and CVD events. Hazard ratios (HRs) were compared among 5 levels of systolic blood...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):446-P
Published: 01 June 2019
..., the impact of BP separately on CAD or CVD in people with different GTSs has yet to be clarified. To clarify this, data from a nationwide claims database involving 293,396 participants without prior CAD or CVD during 2008-16 were analyzed. Multivariate Cox regression model was used to identify risks of a CAD...
Meeting Abstracts
Journal: Diabetes
Diabetes 2021;70(Supplement_1):72-OR
Published: 01 June 2021
.... During a median follow-up of 26 yrs, we observed 203 incident CAD cases (36.9%). At baseline, incident cases were older, more likely to have smoked, have hypertension, longer duration of T1D, higher non-HDL-C and markers of kidney disease and inflammation. Cases were also more likely to have lower HDL-P...
Meeting Abstracts
Journal: Diabetes
Diabetes 2021;70(Supplement_1):983-P
Published: 01 June 2021
...TINA COSTACOU; RACHEL G. MILLER; TREVOR J. ORCHARD Patients with type 1 diabetes (T1D) exhibit a dramatically increased CAD risk compared with the general population. This risk is thought to be similar by sex. However, whether these patterns are maintained with long disease duration is unknown...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):449-P
Published: 01 June 2020
... syndrome for Asians. We have investigated more suitable BMI and WC levels for risk of CAD using large-scale nationwide claims data on people with and without DM in the same cohort. The sample included 157,220 Japanese men 18-72 years of age without a known history of CAD at baseline (DM: 15,465 patients...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1931-P
Published: 01 June 2019
...KATHERINE V. WILLIAMS; CHRISTINA M. SHAY; JULIE PRICE; TREVOR J. ORCHARD; DAVID KELLEY IR in T1D may contribute to CAD risk. We recently reported that SM IR in T1D primarily involves oxidative SM while glycolytic SM is comparable to healthy controls. This study compared systemic glucose disposal...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):433-P
Published: 01 July 2018
... that asymptomatic T2D patients have extensively diseased coronary arteries suggesting a need for more aggressive residual CV risk management. Disclosure A.P. Ofstad: Employee; Self; Boehringer Ingelheim GmbH. S. Arora: None. G.R. Ulimoen: None. K.I. Birkeland: Research Support; Self; AstraZeneca...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):442-P
Published: 01 July 2018
...KAZUYA FUJIHARA; YASUHIRO MATSUBAYASHI; MASARU KITAZAWA; MASAHIKO YAMAMOTO; TAEKO OSAWA; MASANORI KANEKO; NAUTA YAMANAKA; HIROYASU SEIDA; KIMINORI KATO; SATORU KODAMA; HIROHITO SONE Although control of multiple risk factors is essential to prevent CAD in persons with and without DM, longitudinal...
Images
Schematic of bilirubin generation and conjugation in the liver. The physiol...
Published: 17 July 2014
Figure 1 Schematic of bilirubin generation and conjugation in the liver. The physiological properties of bilirubin may explain its ability to protect against the progression of DN. These properties make bilirubin a potential clinical biomarker or therapeutic target for a variety of disease states. BVR, biliverdin reductase; CAD, coronary artery disease; CO, carbon monoxide; CVD, cardiovascular disease; Fe2+, ferrous iron; Fe3+, ferric iron; NOS, nitric oxide synthase; RBC, erythrocyte; TNFα, tumor necrosis factor-α. Figure 1. Schematic of bilirubin generation and conjugation in the liver. The physiological properties of bilirubin may explain its ability to protect against the progression of DN. These properties make bilirubin a potential clinical biomarker or therapeutic target for a variety of disease states. BVR, biliverdin reductase; CAD, coronary artery disease; CO, carbon monoxide; CVD, cardiovascular disease; Fe2+, ferrous iron; Fe3+, ferric iron; NOS, nitric oxide synthase; RBC, erythrocyte; TNFα, tumor necrosis factor-α. More
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):617-P
Published: 01 June 2019
...AMBIKA GOPALAKRISHNAN UNNIKRISHNAN; ASHOK KUMAR DAS; BANSHI D. SABOO; SANJAY KALRA; VAGEESH AYYAR; MANGESH HARIHAR TIWASKAR Background: CAD (Coronary Artery Disease) and diabetes is strongly associated with high low-density lipoproteins (LDL) levels. Objective: Understand evaluation practices...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(Supplement_3):S31–S34
Published: 01 July 1996
... lipoproteine [IDL], LDL, and HDL) in nonobese NIDDM subjects, who were classified into well-controlled, fairly controlled, or poorly controlled states with or without macrovascular complications (macroangiopathy [MA]). The same analyses were also performed on subjects who had coronary artery disease (CAD...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(4):1063–1068
Published: 01 April 2008
... generation and plays an antiatherogenic role in the vascular wall. A common variant in the UCP2 promoter (−866G>A) modulates mRNA expression, with increased expression associated with the A allele. We investigated association of this variant with coronary artery disease (CAD) in two cohorts of type 2...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2002;51(12):3582–3585
Published: 01 December 2002
... antagonist (IL-1ra) is a major modulator of the interleukin-1 pro-inflammatory pathway. We studied the relationship between a variable number tandem repeat (VNTR) polymorphism in intron 2 of the IL-1ra gene (IL1RN) and coronary artery disease (CAD) in patients with and without type 2 diabetes, following 787...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(9):1571–1578
Published: 01 September 2000
...J C Olson; D Edmundowicz; D J Becker; L H Kuller; T J Orchard We studied the relationship of coronary artery calcification (CAC), a marker of coronary atherosclerosis, with prevalent clinical coronary artery disease (CAD) and established cardiovascular disease (CVD) risk factors in a type 1...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(6):736–741
Published: 01 June 1996
... of disease status in normal and coronary artery disease (CAD) groups. We assessed the relationship of pancreatic β-cell secretory products and premature CAD in a casecontrol study of 134 nondiabetic subjects, aged ≤55 years old, carefully defined for CAD status by catheterization and/or thallium stress...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(3):867–870
Published: 01 March 2002
...Jochen Schneider; Joerg Kreuzer; Andreas Hamann; Peter P. Nawroth; Klaus A. Dugi Lipoprotein lipase (LPL) plays a key role in lipid metabolism by hydrolyzing triglycerides in circulating lipoproteins. Low LPL activity has been linked to coronary artery disease (CAD), but the factors influencing LPL...