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dcct-diabetes-control-and-complications-trial

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Journal Articles
Journal: Diabetes
Diabetes 2006;55(12):3556–3565
Published: 01 December 2006
..., an observational follow-up of the Diabetes Control and Complications Trial (DCCT) type 1 diabetes cohort, measured coronary artery calcification (CAC), an index of atherosclerosis, with computed tomography (CT) in 1,205 EDIC patients at ∼7–9 years after the end of the DCCT. We examined the influence of the 6.5...
Journal Articles
Journal: Diabetes
Diabetes 2019;68(2):409–419
Published: 08 November 2018
...Rachel G. Miller; Tina Costacou; Trevor J. Orchard In a recent Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study report, mean HbA1c was the strongest predictor of cardiovascular disease (CVD) after age. In DCCT/EDIC...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(4):870–880
Published: 01 April 1999
...-adjusted collagen sible the design of long-term intervention trials such as the variables were significantly associated with the HbA1c Diabetes Control and Complications Trial (DCCT) (1). The value nearest the biopsy and with cumulative prior DCCT demonstrated that intensive glycemic control HbA1c values...
Journal Articles
Journal: Diabetes
Diabetes 2020;69(5):1000–1010
Published: 12 February 2020
...Barbara H. Braffett; Rose A. Gubitosi-Klug; James W. Albers; Eva L. Feldman; Catherine L. Martin; Neil H. White; Trevor J. Orchard; Maria Lopes-Virella; John M. Lachin; Rodica Pop-Busui; the DCCT/EDIC Research Group The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):113-OR
Published: 01 July 2018
...EDWARD J. BOYKO; LEILA ZELNICK; BARBARA BRAFFETT; RODICA POP-BUSUI; CATHERINE C. COWIE; GAYLE M. LORENZI; ROSE GUBITOSI-KLUG; BERNARD ZINMAN; IAN DE BOER We examined whether prior intensive glycemic control during the DCCT reduced the risk of diabetic foot ulcer (DFU) and lower extremity amputation...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(2):607–613
Published: 21 January 2011
... as common carotid artery intima-media thickness (IMT). RESEARCH DESIGN AND METHODS A total of 1,116 participants (52% men) in the Epidemiology of Diabetes Interventions and Complications (EDIC) trial, a long-term follow-up of the Diabetes Control and Complications Trial (DCCT), had carotid IMT...
Journal Articles
Journal: Diabetes
Diabetes 1986;35(5):530–545
Published: 01 May 1986
...The DCCT Research Group The Diabetes Control and Complications Trial (DCCT) is a randomized, controlled clinical trial designed to assess the'relationship between glycemic control and the development, progression, or amelioration of early vascular complications in persons with insulin-dependent...
Journal Articles
Journal: Diabetes
Diabetes 1988;37(4):476–481
Published: 01 April 1988
...The DCCT Research Group The Diabetes Control and Complications Trial (DCCT) is a multicenter randomized clinical trial studying the effect of intensive insulin therapy on the early vascular and neurological complications of insulin-dependent diabetes mellitus (IDDM). During the feasibility phase...
Journal Articles
Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson, Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Jr., Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M. van Dam, Guozhi Jiang, Claudia H.T. Tam, Andrea O.Y. Luk, Heung Man Lee, Cadmon K.P. Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C.N. Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Marcus G. Pezzolesi, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T. Hiraki, Tarunveer S. Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D. Paterson, David Tregouet, Alexander P. Maxwell, Su Chi Lim, Ronald C.W. Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S. Krolewski, Stephen S. Rich, Joel N. Hirschhorn, Jose C. Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N.A. Palmer, Per-Henrik Groop, Helen M. Colhoun, Leif C. Groop, Mark I. McCarthy, Finnish Diabetic Nephropathy Study (FinnDiane), S. Koivula, T. Uggeldahl, T. Forslund, A. Halonen, A. Koistinen, P. Koskiaho, M. Laukkanen, J. Saltevo, M. Tiihonen, M. Forsen, H. Granlund, A.-C. Jonsson, B. Nyroos, P. Kinnunen, A. Orvola, T. Salonen, A. Vähänen, Kotka R. Paldanius, M. Riihelä, L. Ryysy, Kemi H. Laukkanen, P. Nyländen, A. Sademies, S. Anderson, B. Asplund, U. Byskata, P. Liedes, M. Kuusela, T. Virkkala, A. Nikkola, E. Ritola, Tapiola M. Niska, H. Saarinen, Samaria E. Oukko-Ruponen, T. Virtanen, Viherlaakso A. Lyytinen, Puistola H. Kari, T. Simonen, Suutarila A. Kaprio, J. Kärkkäinen, B. Rantaeskola, Toolo P. Kääriäinen, J. Haaga, A.-L. Pietiläinen, S. Klemetti, T. Nyandoto, E. Rontu, S. Satuli-Autere, Korso R. Toivonen, H. Virtanen Lansimaki, R. Ahonen, M. Ivaska-Suomela, A. Jauhiainen, Martinlaakso M. Laine, T. Pellonpää, R. Puranen, Myyrmaki A. Airas, J. Laakso, K. Rautavaara, Rekola M. Erola, E. Jatkola, Tikkurila R. Lönnblad, A. Malm, J. Mäkelä, E. Rautamo, P. Hentunen, J. Lagerstam, M. Feodoroff, D. Gordin, O. Heikkilä, K. Hietala, J. Fagerudd, M. Korolainen, L. Kyllönen, J. Kytö, S. Lindh, K. Pettersson-Fernholm, M. Rosengård-Bärlund, A. Sandelin, L. Thorn, J. Tuomikangas, T. Vesisenaho, J. Wadén, V. Sipilä, Forssa T. Kalliomäki, J. Koskelainen, R. Nikkanen, N. Savolainen, H. Sulonen, E. Valtonen, L. Norvio, A. Hämäläinen, E. Toivanen, Jamsa A. Parta, I. Pirttiniemi, S. Aranko, S. Ervasti, R. Kauppinen-Mäkelin, A. Kuusisto, T. Leppälä, K. Nikkilä, L. Pekkonen, Kajaani S. Jokelainen, K. Kananen, M. Karjalainen, P. Kemppainen, A.-M. Mankinen, A. Reponen, M. Sankari, P. Suominen, A. Lappalainen, M. Liimatainen, J. Santaholma, A. Aimolahti, E. Huovinen, V. Ilkka, M. Lehtimäki, E. Pälikkö-Kontinen, A. Vanhanen, E. Koskinen, T. Siitonen, E. Huttunen, R. Ikäheimo, P. Karhapää, P. Kekäläinen, M. Laakso, T. Lakka, E. Lampainen, L. Moilanen, S. Tanskanen, L. Niskanen, U. Tuovinen, I. Vauhkonen, E. Voutilainen, Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Ronald C.W. Ma, Juliana C.N. Chan, Yu Huang, Hui-yao Lan, Si Lok, Brian Tomlinson, Stephen K.W. Tsui, Weichuan Yu, Kevin Y.L. Yip, Ting Fung Chan, Xiaodan Fan, Wing Yee So, Cheuk Chun Szeto, Nelson Tang, Andrea O. Luk, Xiaoyu Tian, Guozhi Jiang, Claudia H.T. Tam, Heung Man Lee, Cadmon K.P. Lim, Katie K.H. Chan, Fangying Xie, Alex C.W. Ng, Grace P.Y. Cheung, Ming-wai Yeung, Shi Mai, Fei Xie, Sen Zhang, Pu Yu, Meng Weng, Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, A.P. Maxwell, A.J. McKnight, D.A. Savage, J. Walker, S. Thomas, G.C. Viberti, A.J.M. Boulton, S. Marshall, A.G. Demaine, B.A. Millward, S.C. Bain, GENIE (GEnetics of Nephropathy an International Effort) Consortium, Niina Sandholm, Carol Forsblom, Valma Harjutsalo, Ville-Petteri Mäkinen, Aila J. Ahola, Emma Dahlström, Daniel Gordin, Outi Heikkilä, Kustaa Hietala, Janne Kytö, Markku Lehto, Raija Lithovius, Nicolae Mircea Panduru, Maija Parkkonen, Milla Rosengård-Bärlund, Markku Saraheimo, Jenny Söderlund, Aino Soro-Paavonen, Anna Syreeni, Lena M. Thorn, Nina Tolonen, Johan Wadén, Per-Henrik Groop, Amy Jayne McKnight, Gareth J. McKay, Alexander P. Maxwell, Rany M. Salem, Tamara Isakova, Cameron Palmer, Candace Guiducci, Andrew Taylor, Daniel B. Mirel, Winfred W. Williams, Joel N. Hirschhorn, Jose C. Florez, Eoin P. Brennan, Denise M. Sadlier, Finian Martin, Catherine Godson, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Lynne Mayer, Rose Gubitosi-Klug, Patti Bourne, Mark Schutta, Mary Ellen Lackaye, Naina Sinha Gregory, Davida Kruger, J. Kimberly Jones, Arti Bhan, Ellen Golden, Lloyd Aiello, Mary Larkin, David Nathan, Georgia Ziegler, Susan Caulder, Clare Pittman, Louis Luttrell, Maria Lopes-Virella, Mary Johnson, Kimberly Gunyou, Richard Bergenstal, Brenda Vittetoe, William Sivitz, Nancy Flaherty, John Bantle, Susan Hitt, David Goldstein, Dean Hainsworth, Lori Cimino, Trevor Orchard, Christine Wigley, Samuel Dagogo-Jack, Suzanne Strowig, Philip Raskin, Annette Barnie, Bernard Zinman, Robyn Fahlstrom, Jerry Palmer, Judith Harth, Marsha Driscoll, Charlotte McDonald, Janie Lipps Hagan, Michael May, Lucy Levandoski, Neil White, Patricia Gatcomb, William Tamborlane, Daphne Adelman, Susan Colson, Mark Molitch, Gayle Lorenzi, Sunder Mudaliar, Sherry Johnsonbaugh, Ryan Miller, Janene Canady, David Schade, Maria Luisa Bernal, John Malone, Anthony Morrison, Catherine Martin, William Herman, Rodica Pop-Busui, Catherine Cowie, Ellen Leschek, Patricia Cleary, John Lachin, Bernie Zinman, Gayle Lorenzi, Barbara Braffett, Mike Steffes, Valerie Arends, Barbara Blodi, Ronald Danis, Daniel Lawrence, Hugh Wabers, Elsayed Soliman, Zhu-Ming Zhang, Charles Campbell, Susan Hensley, Lisa Keasler, SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Michael Mark, Markus Albertini, Carine Boustany, Alexander Ehlgen, Martin Gerl, Jochen Huber, Corinna Schölch, Heike Zimdahl-Gelling, Leif Groop, Elisabet Agardh, Emma Ahlqvist, Tord Ajanki, Nibal Al Maghrabi, Peter Almgren, Jan Apelqvist, Eva Bengtsson, Lisa Berglund, Harry Björckbacka, Ulrika Blom-Nilsson, Mattias Borell, Agneta Burström, Corrado Cilio, Magnus Cinthio, Karl Dreja, Pontus Dunér, Daniel Engelbertsen, Joao Fadista, Maria Gomez, Isabel Goncalves, Bo Hedblad, Anna Hultgårdh, Martin E. Johansson, Cecilia Kennbäck, Jasmina Kravic, Claes Ladenvall, Åke Lernmark, Eero Lindholm, Charlotte Ling, Holger Luthman, Olle Melander, Malin Neptin, Jan Nilsson, Peter Nilsson, Tobias Nilsson, Gunilla Nordin, Marju Orho-Melander, Emilia Ottoson-Laakso, Annie Persson, Margaretha Persson, Mats-Åke Persson, Jacqueline Postma, Elisabeth Pranter, Sara Rattik, Gunnar Sterner, Lilian Tindberg, Maria Wigren, Anna Zetterqvist, Mikael Åkerlund, Gerd Ostling, Timo Kanninen, Anni Ahonen-Bishopp, Anita Eliasson, Timo Herrala, Paivi Tikka-Kleemola, Anders Hamsten, Christer Betsholtz, Ami Björkholm, Fariba Foroogh, Guillem Genové, Karl Gertow, Bruna Gigante, Bing He, Karin Leander, Olga McLeod, Maria Nastase-Mannila, Jaako Patrakka, Angela Silveira, Rona Strawbridge, Karl Tryggvason, Max Vikström, John Ohrvik, Anne-May Österholm, Barbara Thorand, Christian Gieger, Harald Grallert, Tonia Ludwig, Barbara Nitz, Andrea Schneider, Rui Wang-Sattler, Astrid Zierer, Giuseppe Remuzzi, Ariela Benigni, Roberta Donadelli, Maria Domenica Lesti, Marina Noris, Norberto Perico, Annalisa Perna, Rossella Piras, Piero Ruggenenti, Erica Rurali, David Dunger, Ludo Chassin, Neil Dalton, John Deanfield, Jane Horsford, Clare Rice, James Rudd, Neil Walker, Karen Whitehead, Max Wong, Helen Colhoun, Fiona Adams, Tahira Akbar, Jill Belch, Harshal Deshmukh, Fiona Dove, Angela Ellingford, Bassam Farran, Mike Ferguson, Gary Henderson, Graeme Houston, Faisel Khan, Graham Leese, Yiyuan Liu, Shona Livingstone, Helen Looker, Margaret McCann, Stuart McGurnaghan, Andrew Morris, David Newton, Colin Palmer, Ewan Pearson, Gillian Reekie, Natalie Smith, Angela Shore, Kuni Aizawa, Claire Ball, Nick Bellenger, Francesco Casanova, Tim Frayling, Phil Gates, Kim Gooding, Andrew Hattersley, Roland Ling, David Mawson, Robin Shandas, David Strain, Clare Thorn, Ulf Smith, Ann Hammarstedt, Hans Häring, Oluf Pedersen, Georgio Sesti, Per-Henrik Groop, Emma Fagerholm, Carol Forsblom, Valma Harjutsalo, Maikki Parkkonen, Niina Sandholm, Nina Tolonen, Iiro Toppila, Erkka Valo, Veikko Salomaa, Aki Havulinna, Kati Kristiansson, Pia Okamo, Tomi Peltola, Markus Perola, Arto Pietilä, Samuli Ripatti, Marketta Taimi, Seppo Ylä-Herttuala, Mohan Babu, Marike Dijkstra, Erika Gurzeler, Jenni Huusko, Ivana Kholová, Markku Laakso, Mari Merentie, Marja Poikolainen, Mark McCarthy, Chris Groves, Thorhildur Juliusdottir, Fredrik Karpe, Vasiliki Lagou, Andrew Morris, Will Rayner, Neil Robertson, Natalie van Zuydam, Claudio Cobelli, Barbara Di Camillo, Francesca Finotello, Francesco Sambo, Gianna Toffolo, Emanuele Trifoglio, Riccardo Bellazzi, Nicola Barbarini, Mauro Bucalo, Christiana Larizza, Paolo Magni, Alberto Malovini, Simone Marini, Francesca Mulas, Silvana Quaglini, Lucia Sacchi, Francesca Vitali, Ele Ferrannini, Beatrice Boldrini, Michaela Kozakova, Andrea Mari, Carmela Morizzo, Lucrecia Mota, Andrea Natali, Carlo Palombo, Elena Venturi, Mark Walker, Carlo Patrono, Francesca Pagliaccia, Bianca Rocca, Pirjo Nuutila, Johanna Haukkala, Juhani Knuuti, Anne Roivainen, Antti Saraste, Paul McKeague, Marco Colombo, Birgit Steckel-Hamann, Krister Bokvist, Sudha Shankar, Melissa Thomas, Li-ming Gan, Suvi Heinonen, Ann-Cathrine Jönsson-Rylander, Remi Momo, Volker Schnecke, Robert Unwin, Anna Walentinsson, Carl Whatling, Everson Nogoceke, Gonzalo Durán Pacheco, Ivan Formentini, Thomas Schindler, Piero Tortoli, Luca Bassi, Enrico Boni, Alessandro Dallai, Francesco Guidi, Matteo Lenge, Riccardo Matera, Alessandro Ramalli, Stefano Ricci, Jacopo Viti, Bernd Jablonka, Dan Crowther, Johan Gassenhuber, Sibylle Hess, Thomas Hubschle, Hans-Paul Juretschke, Hartmut Rutten, Thorsten Sadowski, Paulus Wohlfart, Julia Brosnan, Valerie Clerin, Eric Fauman, Craig Hyde, Anders Malarstig, Nick Pullen, Mera Tilley, Theresa Tuthill, Ciara Vangjeli, Daniel Ziemek
Journal: Diabetes
Diabetes 2018;67(7):1414–1427
Published: 27 April 2018
.... Maxwell; Rany M. Salem; Tamara Isakova; Cameron Palmer; Candace Guiducci; Andrew Taylor; Daniel B. Mirel; Winfred W. Williams; Joel N. Hirschhorn; Jose C. Florez; Eoin P. Brennan; Denise M. Sadlier; Finian Martin; Catherine Godson; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2016;65(5):1370–1379
Published: 19 February 2016
...The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group Risk factors for cardiovascular disease (CVD) are well-established in type 2 but not type 1 diabetes (T1DM). We assessed risk factors in the long-term (mean 27 years...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2015;64(2):631–642
Published: 09 September 2014
...The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group The Diabetes Control and Complications Trial (DCCT) demonstrated that a mean of 6.5 years of intensive therapy aimed at near-normal glucose levels reduced the risk...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 1996;45(10):1289–1298
Published: 01 October 1996
...Diabetes Control and Complications Trial (DCCT) Research Group The Diabetes Control and Complications Trial (DCCT) demonstrated a reduction in the development and progression of the long-term complications of IDDM with intensive therapy aimed at achieving glycemic control as close...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(8):968–983
Published: 01 August 1995
...The Diabetes Control and Complications Trial Research Group The Diabetes Control and Complications Trial (DCCT) demonstrated that a regimen of intensive therapy aimed at maintaining near-normal blood glucose values markedly reduces the risks of development or progression of retinopathy and other...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(12):1355–1361
Published: 01 December 1995
... trials. However, with the exception of the Diabetes Control and Complications Trial (DCCT), long-term trials with adequate statistical power to evaluate clinical outcome endpoints have not been conducted. The changes in nerve function are similar in most of the clinical trials. For instance, in four...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(7):1913–1921
Published: 01 July 2007
...John M. Lachin; Saul Genuth; David M. Nathan; Brandy N. Rutledge The Diabetes Control and Complications Trial (DCCT) demonstrated that intensive therapy aimed at improved glucose control markedly reduced the risk of diabetes complications compared with conventional therapy. The principal...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(4):1238–1244
Published: 01 April 2005
... enrolled in the Diabetes Control and Complications Trial (DCCT) and followed in the Epidemiology of Diabetes Interventions and Complications (EDIC) study. We describe the association of genetic variation in the ACE gene in 1,365 DCCT/EDIC subjects with incident persistent microalbuminuria (n = 312...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(2):383–390
Published: 01 February 1999
... The Epidemiology of Diabetes Interventions and Complications (EDIC) is a multicenter longitudinal observational study of the Diabetes Control and Complications Trial (DCCT) cohort. One of the major objectives of EDIC is to study the development and progression of atherosclerotic cardiovascular...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(Supplement_3):S87–S90
Published: 01 July 1996
...John A Colwell The rationale for intensive insulin therapy and results from major clinical trials in diabetes are reviewed. The Diabetes Control and Complications Trial (DCCT) has shown that intensive insulin therapy will prevent or delay the onset of retinopathy, nephropathy, and neuropathy...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(8):2161–2168
Published: 01 August 2007
... with long-term renal and retinal complications in type 1 diabetes. RESEARCH DESIGN AND METHODS— A total of 1,369 Caucasian subjects with type 1 diabetes from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study had an average of 17...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2005;54(11):3103–3111
Published: 01 November 2005
... of advanced glycation end products (AGEs), have been proposed. We investigated the hypothesis that skin collagen glycation and AGEs predict the risk of progression of microvascular disease. We measured glycation products in the skin collagen of 211 Diabetes Control and Complications Trial (DCCT) volunteers...