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enos-endothelial-nitric-oxide-synthase

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Journal Articles
Journal: Diabetes
Diabetes 2007;56(11):2690–2696
Published: 01 November 2007
...Eric Le Gouill; Maria Jimenez; Christophe Binnert; Pierre-Yves Jayet; Sebastien Thalmann; Pascal Nicod; Urs Scherrer; Peter Vollenweider OBJECTIVE— Recent observations indicate that the delivery of nitric oxide by endothelial nitric oxide synthase (eNOS) is not only critical for metabolic...
Images
Role of NEFAs in prothrombotic state in insulin resistance and diabetes. eN...
Published: 17 February 2015
Figure 1 Role of NEFAs in prothrombotic state in insulin resistance and diabetes. eNOS, endothelial nitric oxide synthase. Figure 1. Role of NEFAs in prothrombotic state in insulin resistance and diabetes. eNOS, endothelial nitric oxide synthase. More
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):484-P
Published: 01 July 2018
... of cardiovascular disease among countries with high wine consumption. We have shown that resveratrol decreases neointimal formation in both mouse and rat models of arterial injury, and also that these effects are exerted through eNOS (endothelial nitric oxide synthase). We hypothesized that resveratrol acts though...
Images
The three nutrient-sensing pathways, mTOR, AMPK, and SIRT1, may be independ...
Published: 12 December 2011
FIG. 2. The three nutrient-sensing pathways, mTOR, AMPK, and SIRT1, may be independently and coordinately involved in the pathogenesis of diabetic nephropathy. 4E-BP, 4E-binding protein; COX2, cyclooxygenase-2; eNOS, endothelial nitric oxide synthase; EPO, erythropoietin; FoxO, forkhead box class ... More
Images
The investigators used microarrays to analyze differential gene expression ...
Published: 13 December 2012
FIG. 1. The investigators used microarrays to analyze differential gene expression from glomeruli in four different comparisons and then generated signaling networks to represent each comparison. Nodes from each of these networks were then compared to examine the overlap between pathways that are ... More
Images
<span class="search-highlight">Oxidative</span> stress of vascular origin induces obesity. <em>Panels</em>...
Published: 14 June 2014
Figure 1 Oxidative stress of vascular origin induces obesity. PanelsA and B depict excessive superoxide generation by the NADPH oxidase complex in VSMCs of tgsm/p22phox mice under baseline conditions and the compensatory vascular and metabolic responses that contribute to preservation of vascular function as reported previously by the authors ( 11 ). WT mice fed a Western diet high in fat for several months exhibit a number of abnormalities typically observed in metabolic syndrome (C). The consequences of feeding tgsm/p22phox mice an HFD for 6 weeks are similar to those observed with long-term HFD feeding (D). ecSOD, extracellular superoxide dismutase; eNOS, endothelial nitric oxide synthase; KO, knockout; PVAT, perivascular fat; RAAS, renin-angiotensin-aldosterone system. Figure 1. Oxidative stress of vascular origin induces obesity. Panels A and B depict excessive superoxide generation by the NADPH oxidase complex in VSMCs of tgsm/p22phox mice under baseline conditions and the compensatory vascular and metabolic responses that contribute to preservation of vascular function as reported previously by the authors (11). WT mice fed a Western diet high in fat for several months exhibit a number of abnormalities typically observed in metabolic syndrome (C). The consequences of feeding tgsm/p22phox mice an HFD for 6 weeks are similar to those observed with long-term HFD feeding (D). ecSOD, extracellular superoxide dismutase; eNOS, endothelial nitric oxide synthase; KO, knockout; PVAT, perivascular fat; RAAS, renin-angiotensin-aldosterone system. More
Images
Insulin (pentagons) enters the skeletal muscle capillary microvasculature w...
Published: 15 November 2012
FIG. 1. Insulin (pentagons) enters the skeletal muscle capillary microvasculature where it can exchange between the plasma and the interstitium. This can be assessed by sampling A/V insulin and quantifying blood flow (white stars) or by sampling lymphatic insulin (black star). Alternatively, a mic... More
Images
Significantly enriched pathways and interaction network for IRS1 interactio...
Published: 15 May 2014
Figure 1 Significantly enriched pathways and interaction network for IRS1 interaction partners. A: Significantly enriched pathways for the IRS1 interaction partners identified in this study revealed by Ingenuity Pathway Analysis and Impact Analysis. The pathways are grouped according to a common theme manually. The pathways were sorted by the database and then by pathway names. The total number of identified IRS1 interaction partners for a given pathway in this study are denoted above each bar. B: A significantly enriched IRS1 interaction network in human skeletal muscle revealed by proteomics and Ingenuity Pathway Analysis. All parameters were set as default, with the exception of the number of molecules per network, which was maximized to 140. The network with the top score (116), which is related to metabolic disorder, was shown, containing 62 molecules derived from the list of 122 IRS1 interaction partners identified in this study. IRS1 is highlighted in purple, and identified IRS1 interaction partners in this study are highlighted in green. Solid and dashed connecting lines indicate the presence of direct and indirect interactions in the Ingenuity database, respectively. eNOS, endothelial nitric oxide synthase; TCA, tricarboxylic acid. Figure 1. Significantly enriched pathways and interaction network for IRS1 interaction partners. A: Significantly enriched pathways for the IRS1 interaction partners identified in this study revealed by Ingenuity Pathway Analysis and Impact Analysis. The pathways are grouped according to a common theme manually. The pathways were sorted by the database and then by pathway names. The total number of identified IRS1 interaction partners for a given pathway in this study are denoted above each bar. B: A significantly enriched IRS1 interaction network in human skeletal muscle revealed by proteomics and Ingenuity Pathway Analysis. All parameters were set as default, with the exception of the number of molecules per network, which was maximized to 140. The network with the top score (116), which is related to metabolic disorder, was shown, containing 62 molecules derived from the list of 122 IRS1 interaction partners identified in this study. IRS1 is highlighted in purple, and identified IRS1 interaction partners in this study are highlighted in green. Solid and dashed connecting lines indicate the presence of direct and indirect interactions in the Ingenuity database, respectively. eNOS, endothelial nitric oxide synthase; TCA, tricarboxylic acid. More
Journal Articles
Journal: Diabetes
Diabetes 2015;64(3):703–705
Published: 17 February 2015
...Figure 1 Role of NEFAs in prothrombotic state in insulin resistance and diabetes. eNOS, endothelial nitric oxide synthase. Figure 1. Role of NEFAs in prothrombotic state in insulin resistance and diabetes. eNOS, endothelial nitric oxide synthase. ...
Journal Articles
Journal: Diabetes
Diabetes 2014;63(7):2216–2218
Published: 14 June 2014
... for 6 weeks are similar to those observed with long-term HFD feeding (D). ecSOD, extracellular superoxide dismutase; eNOS, endothelial nitric oxide synthase; KO, knockout; PVAT, perivascular fat; RAAS, renin-angiotensin-aldosterone system. Figure 1. Oxidative stress of vascular origin induces...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(1):118–126
Published: 01 January 2007
... 1 CMH, methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine DETC, diethyldithiocarbamic acid DHE, dihydroethidium DHFR, dihydrofolate reductase eNOS, endothelial nitric oxide synthase ESR, electron spin resonance H4B, tetrahydrobiopterin l-NAME, N-nitro-l...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(12):2872–2877
Published: 01 December 2007
... of Molecular Medicine, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France. E-mail: burcelin@toulouse.inserm.fr 29 8 2007 25 1 2007 DIABETES 2007 aCSF, artificial cerebrospinal fluid ANS, autonomic nervous system eNOS, endothelial nitric oxide synthase icv...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2003;52(5):1270–1275
Published: 01 May 2003
...Lucilla D. Monti; Cristina Barlassina; Lorena Citterio; Elena Galluccio; Carlo Berzuini; Emanuela Setola; Gianpietro Valsecchi; Pietro Lucotti; Guido Pozza; Luisa Bernardinelli; Giorgio Casari; PierMarco Piatti Endothelial nitric oxide synthase (eNOS) variants were previously demonstrated...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2012;61(12):3063–3065
Published: 15 November 2012
...-mediated endocytosis and subsequent degradation. Small amounts of insulin return via lymphatic drainage because flow through the muscle lymphatic system is only approximately 1/100th that of blood flow to muscle. eNOS, endothelial nitric oxide synthase; IRS, insulin receptor substrate; PI3K, 1...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(6):1629–1637
Published: 01 June 2008
...–induced relaxation were similar in all groups. Endothelium-dependent relaxation in response to shear stress and acetylcholine of MRA and coronary artery from diabetic mice was altered and associated with reduced endothelial nitric oxide synthase (eNOS) expression and phosphorylation. Treated diabetic mice...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(3):666–674
Published: 01 March 2007
...Thomas Thum; Daniela Fraccarollo; Maximilian Schultheiss; Sabrina Froese; Paolo Galuppo; Julian D. Widder; Dimitrios Tsikas; Georg Ertl; Johann Bauersachs Uncoupling of the endothelial nitric oxide synthase (eNOS) resulting in superoxide anion (O2) formation instead of nitric...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(8):2067–2072
Published: 01 August 2004
... (BioRad). eNOS, endothelial nitric oxide synthase HFD, high-fat carbohydrate-free diet NC, normal diet Metabolic insulin resistance is a problem of utmost clinical importance and a major risk factor for cardiovascular morbidity and mortality. Epidemiological studies indicate that insulin...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(3):691–698
Published: 01 March 2006
... with endothelial dysfunction and insulin resistance. However, the effect of vascular PKC activation on insulin-stimulated endothelial nitric oxide (NO) synthase (eNOS) regulation has not been characterized in obesity-associated insulin resistance. Diacylglycerol (DAG) concentration and PKC activity were increased...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(1):168–173
Published: 01 January 2002
..., DAF-2 diacetate; EGM, endothelial growth medium; eNOS, endothelial nitric oxide synthase; FAU, fluorescence arbitrary units; FBS, fetal bovine serum; HAEC, human aortic endothelial cell; l-NAME, l-nitroarginine-methyl-ester; NO, nitric oxide; PBS, phosphate-buffered saline; PI...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(3):577–583
Published: 01 March 2008
... of resistin significantly impaired dose-dependent insulin-evoked vasodilation by reducing endothelial nitric oxide synthase (eNOS) enzymatic activity. This effect of resistin was selective for insulin vascular action, since vasodilatation induced by increasing doses of acetylcholine or nitroglycerin...