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iaa-insulin-autoantibody

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Journal Articles
Journal: Diabetes
Diabetes 1987;36(1):66–72
Published: 01 January 1987
...Jose-Luis Diaz; Terence Wilkin The binding profiles of insulin autoantibodies (IAA) and insulin antibodies (IA) to highly purified species variants and fragments of insulin were studied in direct immunospecific enzyme-linked immunosorbent assay (ELISA) and indirect absorption experiments...
Images
Prevalence of genotypes, <span class="search-highlight">autoantibodies</span> to ZnT8, and other antigens in rela...
Published: 01 October 2008
FIG. 3. Prevalence of genotypes, autoantibodies to ZnT8, and other antigens in relation to age ofclinical diagnosis. Data from 335 individuals were subdivided in groups 4 years apart and analyzed with respect to distribution of genotypes (A); presence of insulin, GAD, and IA-2 autoantibodies (B); ZnT8 autoreactivity as defined by Gln, Arg, and Trp probes (C); and ZnT8 autoreactivity relative to isoepitope classification (D). Statistical significance relative to the 5- to 15-year-old reference group was determined by Fisher's exact test: *P < 0.05; **P < 0.01. IAA, insulin autoantibody. FIG. 3. Prevalence of genotypes, autoantibodies to ZnT8, and other antigens in relation to age ofclinical diagnosis. Data from 335 individuals were subdivided in groups 4 years apart and analyzed with respect to distribution of genotypes (A); presence of insulin, GAD, and IA-2 autoantibodies (B); ZnT8 autoreactivity as defined by Gln, Arg, and Trp probes (C); and ZnT8 autoreactivity relative to isoepitope classification (D). Statistical significance relative to the 5- to 15-year-old reference group was determined by Fisher's exact test: *P < 0.05; **P < 0.01. IAA, insulin autoantibody. More
Images
Progression of the type 1 diabetes disease process. This is a cellular auto...
Published: 01 January 2011
FIG. 1. Progression of the type 1 diabetes disease process. This is a cellular autoimmune process occurring in individuals with a genetic predisposition to the disease, presumably triggered by some environmental factor. Humoral antibodies indicate that the disease process is underway, and there is then progressive impairment of β-cell function manifested by progressive deterioration of glucose metabolism. The time frame is variable, so the x-axis is dimensionless. IAA, insulin autoantibody; ICA, islet cell antibody; IVGTT, intravenous glucose tolerance test; OGTT, oral glucose tolerance test. FIG. 1. Progression of the type 1 diabetes disease process. This is a cellular autoimmune process occurring in individuals with a genetic predisposition to the disease, presumably triggered by some environmental factor. Humoral antibodies indicate that the disease process is underway, and there is then progressive impairment of β-cell function manifested by progressive deterioration of glucose metabolism. The time frame is variable, so the x-axis is dimensionless. IAA, insulin autoantibody; ICA, islet cell antibody; IVGTT, intravenous glucose tolerance test; OGTT, oral glucose tolerance test. More
Journal Articles
Journal: Diabetes
Diabetes 1997;46(4):713–716
Published: 01 April 1997
...J Ramón Bilbao; Begoña Calvo; Inés Urrutia; Alberto Linares; Luis Castaño Insulin autoantibodies (IAAs) are present in ∼60% of type I diabetes patients at onset and are used as predictors for the disease. Although the prevalence of IAAs in the general population has been reported to be <1...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(10):1227–1232
Published: 01 October 1995
... a striking association between the human leukocyte antigen (HLA) class II alleles DRB1*0406/DQA1* 0301/DQB1*0302 and Japanese IAS patients with polyclonal insulin autoantibodies (IAAs) and T-cell recognition of human insulin in the context of DRB1*0406 molecules. Because of such a strong HLA association...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(9):1029–1032
Published: 01 September 1995
.... Insulin autoantibodies (IAAs) were found in 3.4 and 15.4% of ICA+ children and first-degree relatives, respectively. Susceptibility alleles at the human leukocyte antigen (HLA)-DQB1 locus were observed significantly more frequently in children in whom ICA titers ≥20 Juvenile Diabetes Foundation...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(3):882–886
Published: 01 March 2003
...-secreting β-cells. Insulin autoantibodies (IAAs) are often present in humans for years, and in NOD mice for weeks, before the onset of diabetes. We have evaluated the expression of IAAs in NOD mice and in diabetes-resistant NOD congenic strains to characterize the association of autoantibody expression...
Journal Articles
Journal: Diabetes
Diabetes 1992;41(7):782–787
Published: 01 July 1992
... the frequencies of antibodies to intact GAD, tryptic fragments of islet 64,000-Mr antigen, islet cell antibodies (ICAs), and insulin autoantibodies (IAAs) in sera from 58 nondiabetic identical twins of patients with IDDM, of whom 12 subsequently developed diabetes. ICA, antibodies to intact...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(12):1706–1710
Published: 01 December 1996
... and in all infants before the age of 9 months. Insulin antibodies were eliminated before the same age in all cases but one. The higher the initial antibody level was, the longer the time required for elimination. Four infants tested positive for insulin autoantibodies (IAAs) on at least one occasion during...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(7):1389–1394
Published: 01 July 1999
...O Vaarala; M Knip; J Paronen; A M Hämäläinen; P Muona; M Väätäinen; J Ilonen; O Simell; H K Akerblom Insulin autoantibodies (IAAs) often appear as the first sign of islet cell autoimmunity in prediabetic children. Because cow's milk contains bovine insulin, we followed the development of insulin...
Images
Sera with <span class="search-highlight">IAA</span> from 13 subjects in  Fig. 6  with single or multiple islet au...
Published: 12 December 2011
FIG. 7. Sera with IAA from 13 subjects in Fig. 6 with single or multiple islet autoantibodies were incubated with different concentrations of either proinsulin (A) or insulin (B) and analyzed with our standard mIAA radioassay. IAA from subjects with single autoantibody (dotted line), compared with subjects with multiple autoantibodies (solid line), required higher concentrations of proinsulin and insulin for one-half maximal inhibition. Results were expressed as percent of signal not absorbed. (A high-quality color representation of this figure is available in the online issue.) FIG. 7. Sera with IAA from 13 subjects in Fig. 6 with single or multiple islet autoantibodies were incubated with different concentrations of either proinsulin (A) or insulin (B) and analyzed with our standard mIAA radioassay. IAA from subjects with single autoantibody (dotted line), compared with subjects with multiple autoantibodies (solid line), required higher concentrations of proinsulin and insulin for one-half maximal inhibition. Results were expressed as percent of signal not absorbed. (A high-quality color representation of this figure is available in the online issue.) More
Journal Articles
Journal: Diabetes
Diabetes 1989;38(2):172–181
Published: 01 February 1989
...Terence J Wilkin; Steven L Schoenfeld; Jose-Luis Diaz; Viggo Kruse; Ezio Bonifacio; Jerry P Palmer Insulin autoantibodies (IAAs) are currently the subject of intensive investigation as potential markers for autoimmune insulitis. However, the results of different reports vary widely. In an attempt...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(11):2451–2458
Published: 01 November 2001
... measurement. Insulin autoantibodies (IAA) were measured by radiobinding assay (RBA) by four laboratories and by enzyme-linked immunosorbent assay (ELISA) in one laboratory. Using the 99th percentile of BALB/c and B6 control mice as the threshold definition of positivity, IAA by RBA were detected in NOD mice...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(10):1176–1179
Published: 01 October 1995
... insulin release; GAD, glutamic acid decarboxylase; IAA, insulin autoantibody; ICA, islet cell antibody; IVGTT, intravenous glucose tolerance test. 14 2 1995 07 6 1995 07 6 1995 Copyright © 1995 by the American Diabetes Association 1995 Late Progression to Diabetes and Evidence...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(11):1340–1344
Published: 01 November 1995
.... 2 AA, autoantibody; CV, coefficient of variation; ELISA, enzyme-linked immunosorbent assay; GAA, GAD65 autoantibody; GAD, glutamic acid decarboxylase; IAA, insulin autoantibody; ICA, islet cell antibody/antigen; IDDM, insulin-dependent diabetes mellitus; PCR, polymerase chain reaction...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(3):646–651
Published: 01 March 2002
... followed 4,590 consecutive newborns with 8 or 3% HLA-DQB1 conferred risk for type 1 diabetes at 3-, 6-, or 12-month intervals up to 5.5 years of age. Islet cell autoantibodies (ICAs) and, in the 137 children with ICAs, insulin autoantibodies (IAAs), GAD65 autoantibodies (GADAs), and IA-2 protein...
Journal Articles
Journal: Diabetes
Diabetes 1994;43(11):1304–1310
Published: 01 November 1994
... analysis with other humoral markers. We examined autoantibodies to insulin (IAAs), glutamic acid decarboxylase (GAD), and Mr 37,000 and Mr 40,000 fragments of islet antigens (37 and 40 kDa) together with ICA subtypes in 101 family members with ICAs ≥10 Juvenile...
Journal Articles
Journal: Diabetes
Diabetes 1994;43(10):1229–1233
Published: 01 October 1994
... of Colorado Health Sciences Center, Box B140, 4200 East 9th Avenue, Denver, CO 80262. 1 GAD, glutamic acid decarboxylase; GAA, glutamic acid decarboxylase antibody; ICA, islet cell antibody; IAA, insulin autoantibody; GABA, γ-amino-n-butyric acid; IVGTT, intravenous glucose tolerance test; FPIR...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(3):460–468
Published: 01 March 1999
...A G Ziegler; M Hummel; M Schenker; E Bonifacio The temporal development of autoantibodies was studied in 1,353 offspring of parents with type 1 diabetes. Islet cell antibodies (ICAs) and autoantibodies to insulin (IAAs), glutamic acid decarboxylase, and IA-2 were measured at birth, 9 months, 2...
Journal Articles
Journal: Diabetes
Diabetes 1994;43(1):154–160
Published: 01 January 1994
... an immunoprecipitation assay. The determination of GAD-ab in the 81 islet cell antibody (ICA) and insulin autoantibody (IAA) negative healthy individuals established a normal range (mean ± 2 SD); 2 healthy individuals (2.5%) possessed GAD-ab levels above this range, but became negative on follow-up. None of 86 ICA...