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icv-intracerebroventricular

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Time line illustrating the course of treatments and tests for experiment 2....
Published: 01 August 2005
FIG. 1. Time line illustrating the course of treatments and tests for experiment 2. icv, intracerebroventricular. FIG. 1. Time line illustrating the course of treatments and tests for experiment 2. icv, intracerebroventricular. More
Images
Intraperitoneal and <span class="search-highlight">intracerebroventricular</span> leptin are sufficient to alter ...
Published: 23 April 2011
FIG. 4. Intraperitoneal and intracerebroventricular leptin are sufficient to alter body composition and serum insulin levels. Adipose tissue and gastrocnemius muscle weights in mice treated with intraperitoneal (A, C) or intracerebroventricular (B, D) leptin for 1 week are shown. GTTs (E, F) and serum insulin levels (G, H) before and 30 min after glucose injection are shown. Numbers of animals are indicated in each figure. For intraperitoneal leptin study, aP < 0.05 vs. wt RF; bP < 0.05 vs. ob/ob RF; cP < 0.05 vs. ob/ob CR. For intracerebroventricular leptin study, aP < 0.05 vs. wt CR intracerebroventricular saline; cP < 0.05 vs. ob/ob CR intracerebroventricular saline. icv, intracerebroventricular; L 1 wk, 1 week of leptin treatment; RF, random fed; wt, wild type. FIG. 4. Intraperitoneal and intracerebroventricular leptin are sufficient to alter body composition and serum insulin levels. Adipose tissue and gastrocnemius muscle weights in mice treated with intraperitoneal (A, C) or intracerebroventricular (B, D) leptin for 1 week are shown. GTTs (E, F) and serum insulin levels (G, H) before and 30 min after glucose injection are shown. Numbers of animals are indicated in each figure. For intraperitoneal leptin study, aP < 0.05 vs. wt RF; bP < 0.05 vs. ob/ob RF; cP < 0.05 vs. ob/ob CR. For intracerebroventricular leptin study, aP < 0.05 vs. wt CR intracerebroventricular saline; cP < 0.05 vs. ob/ob CR intracerebroventricular saline. icv, intracerebroventricular; L 1 wk, 1 week of leptin treatment; RF, random fed; wt, wild type. More
Images
Central administration of apoE dose-dependently reduced food intake at the ...
Published: 01 August 2008
FIG. 1. Central administration of apoE dose-dependently reduced food intake at the beginning of the dark period in ad libitum–fed (A) or 24 h–fasted (B) rats. Values are expressed as means ± SE, n = 7. icv, intracerebroventricular. *P < 0.05, **P < 0.01 vs. saline controls. FIG. 1. Central administration of apoE dose-dependently reduced food intake at the beginning of the dark period in ad libitum–fed (A) or 24 h–fasted (B) rats. Values are expressed as means ± SE, n = 7. icv, intracerebroventricular. *P < 0.05, **P < 0.01 vs. saline controls. More
Images
Effect of central leptin infusion on glucose levels in T1D <em>LIC:Vgat</em>...
Published: 28 January 2016
Figure 1 Effect of central leptin infusion on glucose levels in T1D LIC:Vgatflox/flox and LIC:Vglut2flox/flox mice. A: Representative images of pancreata from non-T1D and T1D mice costained for insulin (red) and glucagon (green). Scale bars = 25 μm. Measurements for plasma glucose levels (B) and daily food intake (C). All data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. other groups (n = 5–8). icv, intracerebroventricular. Figure 1. Effect of central leptin infusion on glucose levels in T1D LIC:Vgatflox/flox and LIC:Vglut2flox/flox mice. A: Representative images of pancreata from non-T1D and T1D mice costained for insulin (red) and glucagon (green). Scale bars = 25 μm. Measurements for plasma glucose levels (B) and daily food intake (C). All data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. other groups (n = 5–8). icv, intracerebroventricular. More
Images
Intraperitoneal and <span class="search-highlight">intracerebroventricular</span> leptin are sufficient to normal...
Published: 23 April 2011
FIG. 5. Intraperitoneal and intracerebroventricular leptin are sufficient to normalize basal and insulin-stimulated palmitate oxidation in caloric-restricted ob/ob hearts. Basal and insulin-stimulated palmitate oxidation after 1 week of intraperitoneal (A) or intracerebroventricular leptin (B). C and D: qPCR analysis from noninsulin-stimulated perfused hearts. WT RF values are normalized to 1 and shown as the dashed line. MCAD, medium chain acyl CoA dehydrogenase; LCAD, long chain acyl CoA dehydrogenase; CD36, CD36 antigen; HADHa, hydroxyacyl-CoA dehydrogenase α-subunit; HADHb, hydroxyacyl-CoA dehydrogenase β-subunit. For intraperitoneal leptin study, aP < 0.05 vs. wt RF; bP < 0.05 vs. ob/ob RF; cP < 0.05 vs. ob/ob CR; *P < 0.05 vs. noninsulin-stimulated hearts from the same treatment group. For intracerebroventricular leptin study, aP < 0.05 vs. wt CR intracerebroventricular saline; cP < 0.05 vs. ob/ob CR intracerebroventricular saline; *P < 0.05 vs. noninsulin-stimulated hearts from the same treatment group. CR, caloric restriction; dhw, dry heart weight; icv, intracerebroventricular; L 1 wk, 1 week of leptin treatment; RF, random fed; wt, wild type. FIG. 5. Intraperitoneal and intracerebroventricular leptin are sufficient to normalize basal and insulin-stimulated palmitate oxidation in caloric-restricted ob/ob hearts. Basal and insulin-stimulated palmitate oxidation after 1 week of intraperitoneal (A) or intracerebroventricular leptin (B). C and D: qPCR analysis from noninsulin-stimulated perfused hearts. WT RF values are normalized to 1 and shown as the dashed line. MCAD, medium chain acyl CoA dehydrogenase; LCAD, long chain acyl CoA dehydrogenase; CD36, CD36 antigen; HADHa, hydroxyacyl-CoA dehydrogenase α-subunit; HADHb, hydroxyacyl-CoA dehydrogenase β-subunit. For intraperitoneal leptin study, aP < 0.05 vs. wt RF; bP < 0.05 vs. ob/ob RF; cP < 0.05 vs. ob/ob CR; *P < 0.05 vs. noninsulin-stimulated hearts from the same treatment group. For intracerebroventricular leptin study, aP < 0.05 vs. wt CR intracerebroventricular saline; cP < 0.05 vs. ob/ob CR intracerebroventricular saline; *P < 0.05 vs. noninsulin-stimulated hearts from the same treatment group. CR, caloric restriction; dhw, dry heart weight; icv, intracerebroventricular; L 1 wk, 1 week of leptin treatment; RF, random fed; wt, wild type. More
Journal Articles
Journal: Diabetes
Diabetes 1997;46(4):717–719
Published: 01 April 1997
.... touabi@cmu.unige.ch . 1 ICV, intracerebroventricular; NPY, neuropeptide Y. 02 12 1996 29 1 1997 29 1 1997 Copyright © 1997 by the American Diabetes Association 1997 Glucocorticoids as Counterregulatory Hormones of Leptiii Toward an Understanding of Leptin Resistance K.E...
Images
Disruption of the LepR → STAT3 signaling pathway abrogated the antidiabetic...
Published: 28 January 2016
Figure 5 Disruption of the LepR → STAT3 signaling pathway abrogated the antidiabetic effect of central leptin. A: Plasma glucose levels (n = 4–7). ***P < 0.001 vs. the other groups. B: Daily food intake (n = 4–7). **P < 0.01 vs. the other groups. C: Representative images of pancreata from saline- and leptin-treated T1D LepRs/s mice costained for insulin (red) and glucagon (green). Scale bars = 25 μm. D: Plasma insulin levels were measured at day 13 (n = 4–6). ***P < 0.001 vs. all other groups. E: Expression of p-S6 by intraperitoneal (i.p.) leptin treatment in the hypothalamus of the indicated mouse groups. Scale bars = 250 μm. 3V, third ventricle. Levels of plasma glucagon (F) and corticosterone (G) were measured at day 13. *P < 0.05 vs. the other groups. All data are represented as the mean ± SEM. icv, intracerebroventricular. Figure 5. Disruption of the LepR → STAT3 signaling pathway abrogated the antidiabetic effect of central leptin. A: Plasma glucose levels (n = 4–7). ***P < 0.001 vs. the other groups. B: Daily food intake (n = 4–7). **P < 0.01 vs. the other groups. C: Representative images of pancreata from saline- and leptin-treated T1D LepRs/s mice costained for insulin (red) and glucagon (green). Scale bars = 25 μm. D: Plasma insulin levels were measured at day 13 (n = 4–6). ***P < 0.001 vs. all other groups. E: Expression of p-S6 by intraperitoneal (i.p.) leptin treatment in the hypothalamus of the indicated mouse groups. Scale bars = 250 μm. 3V, third ventricle. Levels of plasma glucagon (F) and corticosterone (G) were measured at day 13. *P < 0.05 vs. the other groups. All data are represented as the mean ± SEM. icv, intracerebroventricular. More
Journal Articles
Journal: Diabetes
Diabetes 2016;65(4):1040–1049
Published: 28 January 2016
.... Measurements for plasma glucose levels (B) and daily food intake (C). All data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. other groups (n = 5–8). icv, intracerebroventricular. Figure 1. Effect of central leptin...
Includes: Supplementary data
Images
Effects of central leptin infusion in <em>LIC:Vgat<sup>flox/flox</sup>:</em>...
Published: 28 January 2016
Figure 4 Effects of central leptin infusion in LIC:Vgatflox/flox:Vglut2flox/flox mice with T1D. A: Representative images of pancreata from non-T1D and T1D mice costained for insulin (red) and glucagon (green). Scale bars = 25 μm. B: Expression of pSTAT3 in the hypothalamus taken from LIC:Vgatflox/flox:Vglut2 flox/flox mice at day 13 of the experiment. Scale bar = 250 μm. f, fornix. C: Plasma glucose levels (n = 4–6). ***P < 0.001 vs. the other groups, #P < 0.05 vs. control/T1D/leptin group. D: Daily food intake (n = 5–6). *P < 0.05, **P < 0.01, #P < 0.05, ##P < 0.01 vs. control/T1D/saline group. E: Plasma insulin levels were measured at day 13 (n = 5). ***P < 0.001 vs. the other groups. Plasma glucagon (F) and corticosterone (G) levels were measured at day 13 (n = 5–6). *P < 0.05, **P < 0.01 vs. the other groups. All data are represented as the mean ± SEM. icv, intracerebroventricular. Figure 4. Effects of central leptin infusion in LIC:Vgatflox/flox:Vglut2flox/flox mice with T1D. A: Representative images of pancreata from non-T1D and T1D mice costained for insulin (red) and glucagon (green). Scale bars = 25 μm. B: Expression of pSTAT3 in the hypothalamus taken from LIC:Vgatflox/flox:Vglut2 flox/flox mice at day 13 of the experiment. Scale bar = 250 μm. f, fornix. C: Plasma glucose levels (n = 4–6). ***P < 0.001 vs. the other groups, #P < 0.05 vs. control/T1D/leptin group. D: Daily food intake (n = 5–6). *P < 0.05, **P < 0.01, #P < 0.05, ##P < 0.01 vs. control/T1D/saline group. E: Plasma insulin levels were measured at day 13 (n = 5). ***P < 0.001 vs. the other groups. Plasma glucagon (F) and corticosterone (G) levels were measured at day 13 (n = 5–6). *P < 0.05, **P < 0.01 vs. the other groups. All data are represented as the mean ± SEM. icv, intracerebroventricular. More
Images
A brain ROS donor increases femoral arterial blood flow and reduces heart r...
Published: 01 October 2008
FIG. 7. A brain ROS donor increases femoral arterial blood flow and reduces heart rate in a dose-dependent manner. In A, the femoral arterial blood flow rate was recorded under basal conditions. aCSF or hydrogen peroxide (H2O2, low 2 nmol/min and high 20 nmol/min) were infused in the lateral ventricle at the time indicated by the arrow. Statistical significance (P < 0.05) was determined between mice infused with aCSF or H2O2. In B, the femoral arterial blood flow rate was recorded in hyperglycemic conditions and in the presence of Ex4 infused into the brain (arrow at −30 min). After 120 min, an infusion of hydrogen peroxide was performed in a separate group of mice (see arrow at 120 min, 20 nmol/min). aCSF infusion under the same experimental conditions did not modify the blood flow (not shown). In C, the mean heart rate was recorded simultaneously. Data are means ± SE for 5–7 mice per group. icv, intracerebroventricular; iv, intravenous. FIG. 7. A brain ROS donor increases femoral arterial blood flow and reduces heart rate in a dose-dependent manner. In A, the femoral arterial blood flow rate was recorded under basal conditions. aCSF or hydrogen peroxide (H2O2, low 2 nmol/min and high 20 nmol/min) were infused in the lateral ventricle at the time indicated by the arrow. Statistical significance (P < 0.05) was determined between mice infused with aCSF or H2O2. In B, the femoral arterial blood flow rate was recorded in hyperglycemic conditions and in the presence of Ex4 infused into the brain (arrow at −30 min). After 120 min, an infusion of hydrogen peroxide was performed in a separate group of mice (see arrow at 120 min, 20 nmol/min). aCSF infusion under the same experimental conditions did not modify the blood flow (not shown). In C, the mean heart rate was recorded simultaneously. Data are means ± SE for 5–7 mice per group. icv, intracerebroventricular; iv, intravenous. More
Images
Hypothalamic ROS production is required to restrain food intake during hype...
Published: 01 January 2007
FIG. 4. Hypothalamic ROS production is required to restrain food intake during hypertriglyceridemia. A: Experimental procedures of food intake measurement. B: Effect of GSH-EE cerebral delivery on hypertriglyceridemia-induced ROS production. GSH-EE or vehicles were infused in the third lateral ventricle before intraperitoneal injection of either intralipid (IL) or saline. ROS levels were assessed in ventral hypothalamus 30 min after intraperitoneal injection as described above. Data are means ± SE (n = 6). *Significant differences between vehicle and controls, P < 0.05. ‡Significant differences between vehicle- and intralipid-treated rats, P < 0.05. C: Effect of GSH-EE cerebral delivery on the hypertriglyceridemia-induced satiety. Food intake was assessed by weighing residual chow at different times. Data are means ± SE (n = 6). *Significant differences between vehicle and controls, P < 0.05. ‡Significant differences between vehicle- and intralipid-treated rats, P < 0.05. icv, intracerebroventricular; IL, intralipid. FIG. 4. Hypothalamic ROS production is required to restrain food intake during hypertriglyceridemia. A: Experimental procedures of food intake measurement. B: Effect of GSH-EE cerebral delivery on hypertriglyceridemia-induced ROS production. GSH-EE or vehicles were infused in the third lateral ventricle before intraperitoneal injection of either intralipid (IL) or saline. ROS levels were assessed in ventral hypothalamus 30 min after intraperitoneal injection as described above. Data are means ± SE (n = 6). *Significant differences between vehicle and controls, P < 0.05. ‡Significant differences between vehicle- and intralipid-treated rats, P < 0.05. C: Effect of GSH-EE cerebral delivery on the hypertriglyceridemia-induced satiety. Food intake was assessed by weighing residual chow at different times. Data are means ± SE (n = 6). *Significant differences between vehicle and controls, P < 0.05. ‡Significant differences between vehicle- and intralipid-treated rats, P < 0.05. icv, intracerebroventricular; IL, intralipid. More
Journal Articles
Journal: Diabetes
Diabetes 2008;57(4):836–840
Published: 01 April 2008
... and plasma glucose levels in rodents with diabetes and obesity. RESEARCH DESIGN AND METHODS— We performed intracerebroventricular (ICV) administration of lactate to enhance central lactate metabolism in 1) early-onset streptozotocin-induced uncontrolled diabetic rodents, 2) experimentally...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(8):2471–2476
Published: 01 August 2005
...FIG. 1. Time line illustrating the course of treatments and tests for experiment 2. icv, intracerebroventricular. FIG. 1. Time line illustrating the course of treatments and tests for experiment 2. icv, intracerebroventricular. ...
Journal Articles
Journal: Diabetes
Diabetes 1997;46(2):209–214
Published: 01 February 1997
... Geneva 4, Switzerland. Received for publication 17 June 1996 and accepted in revised form 29 August 1996. CRF, corticotropin-releasing factor; ICV, intracerebroventricular; NPY, operated at 7 weeks of age, were purchased from IFFA CREDO (L'Arbresle, neuropeptide Y. France) and housed individually under...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(5):1424–1434
Published: 23 April 2011
... < 0.05 vs. ob/ob RF; cP < 0.05 vs. ob/ob CR. For intracerebroventricular leptin study, aP < 0.05 vs. wt CR intracerebroventricular saline; cP < 0.05 vs. ob/ob CR intracerebroventricular saline. icv...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(7):1101–1105
Published: 01 July 2000
...I Cusin; J Rouru; T Visser; A G Burger; F Rohner-Jeanrenaud We have shown previously that continuous (6 days) intracerebroventricular (ICV) leptin infusion in normal rats resulted in decreases in food intake and body weight. A reduction of food intake imposed on control rats (pair-feeding), aimed...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(10):2577–2587
Published: 01 October 2008
... heart rate was recorded simultaneously. Data are means ± SE for 5–7 mice per group. icv, intracerebroventricular; iv, intravenous. FIG. 7. A brain ROS donor increases femoral arterial blood flow and reduces heart rate in a dose-dependent manner. In A, the femoral arterial blood flow rate was recorded...
Journal Articles
Journal: Diabetes
Diabetes 1997;46(12):2040–2043
Published: 01 December 1997
... the levels of neuropeptide Y (NPY) in the central nervous system (CNS). Because obesity and hyperinsulinism are also frequently associated with hypertension, we studied the effect of the intracerebroventricular (ICV) administration of leptin on mean arterial pressure (MAP), heart rate, vascular flows...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(10):1446–1450
Published: 01 October 1996
...I Cusin; Françoise Rohner-Jeanrenaud; Alain Stricker-Krongrad; Bernard Jeanrenaud The effect of different doses of leptin, given as an intracerebroventricular (ICV) bolus, on body weight gain and food intake was investigated during refeeding, following a 24-h fast in lean (FA/fa) rats...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(2):147–151
Published: 01 February 1995
...Alfred J Sipols; Denis G Baskin; Michael W Schwartz To test the hypothesis that diabetic hyperphagia results from insulin deficiency in the brain, diabetic rats (streptozotocin-induced) were given an intracerebroventricular (ICV) infusion of saline or insulin (at a dose that did not affect plasma...