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in Programmed Cell Death-4 Deficiency Prevents Diet-Induced Obesity, Adipose Tissue Inflammation, and Insulin Resistance > Diabetes
Published: 16 November 2013
FIG. 5. PDCD4 deficiency attenuates WAT inflammation in HFD-fed mice. WT and PDCD4−/− mice were fed a ND or HFD for 24 weeks. The macrophage infiltration in epididymal adipose tissues and inflammatory cytokine secretion by epididymal adipose tissue explants were detected. (A) Immunohistochemical study (CD68 staining) and (B) percentage of CD68+ macrophages on sections from epididymal adipose tissues (n ≥ 3 mice/condition); the arrows indicate inflammation. Original magnification is 200, scale bar is 50 μm. (C) Representative data of cytometric bead array immunoassay and (D–I) statistical data for inflammation detection on supernatants from cultured epididymal adipose tissue explants (n = 4–9 mice/group). Data are presented as mean ± SEM. IFN-γ, interferon-γ; MCP, monocyte chemoattractant protein. *P < 0.05, **P < 0.01, ***P < 0.001. FIG. 5. PDCD4 deficiency attenuates WAT inflammation in HFD-fed mice. WT and PDCD4−/− mice were fed a ND or HFD for 24 weeks. The macrophage infiltration in epididymal adipose tissues and inflammatory cytokine secretion by epididymal adipose tissue explants were detected. (A) Immunohistochemical study (CD68 staining) and (B) percentage of CD68+ macrophages on sections from epididymal adipose tissues (n ≥ 3 mice/condition); the arrows indicate inflammation. Original magnification is 200, scale bar is 50 μm. (C) Representative data of cytometric bead array immunoassay and (D–I) statistical data for inflammation detection on supernatants from cultured epididymal adipose tissue explants (n = 4–9 mice/group). Data are presented as mean ± SEM. IFN-γ, interferon-γ; MCP, monocyte chemoattractant protein. *P < 0.05, **P < 0.01, ***P < 0.001. More
Published: 01 May 1997
...Manuel E Baldeón; David J Neece; Dipankar Nandi; John J Monaco; H Rex Gaskins The mouse pancreatic βTC3 and βTC6-F7 cell lines were used to characterize the effects of interferon-γ (IFN-γ) on (β-cell phenotype and function. Initially, intracellular and secreted insulin were compared in glucose...
Astrid G.S. van Halteren, Evelyne van Etten, Esther C. de Jong, Roger Bouillon, Bart O. Roep, Chantal Mathieu
Published: 01 July 2002
... addition of TX527 impaired interleukin (IL)-4 and granulocyte/macrophage colony-stimulating factor (GM-CSF)-driven DC differentiation as well as lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-induced maturation into Th1-promoting DC (DC1), as characterized by marked changes in DC morphology...
Published: 01 June 2020
...GAURANG JHALA; TINGTING GE; BALASUBRAMANIAN KRISHNAMURTHY; THOMAS KAY; HELEN E. THOMAS Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, play an important role in facilitating the destruction of insulin-secreting β cells by CD8...
Published: 01 June 1996
... on the number, activity, or type of inflammatory cells that invade the islets in type I diabetes. To examine directly the role of interferon (IFN)-γ in a mouse model of type I diabetes, we have introduced an inactivating mutation in the IFN-γ gene (ifg) into NOD mice. The genetic absence of IFN-γ does...
John P. Driver, Jeremy J. Racine, Cheng Ye, Deanna J. Lamont, Brittney N. Newby, Caroline M. Leeth, Harold D. Chapman, Todd M. Brusko, Yi-Guang Chen, Clayton E. Mathews, David V. Serreze
Published: 05 December 2016
... by autoreactive CD4+ and CD8+ T cells of interferon-γ (IFN-γ), generally considered a proinflammatory cytokine. However, IFN-γ can also participate in tolerance-induction pathways, indicating it is not solely proinflammatory. This study addresses how IFN-γ can suppress activation...
Includes: Supplementary data
Jelena Todoric, Birgit Strobl, Alexander Jais, Nicole Boucheron, Martina Bayer, Sabine Amann, Josefine Lindroos, Raffaele Teperino, Gerhard Prager, Martin Bilban, Wilfried Ellmeier, Franz Krempler, Mathias Müller, Oswald Wagner, Wolfgang Patsch, J. Andrew Pospisilik, Harald Esterbauer
Published: 21 May 2011
... cells and level of the cytokine interferon-γ (IFN-γ) are increased in adipose tissue in obesity. Hedgehog (Hh) signaling has been shown to potently inhibit white adipocyte differentiation. In light of recent findings in neurons that IFN-γ and Hh signaling cross-talk, we examined their potential...
Includes: Supplementary data
Published: 01 December 2001
...Mark M.W. Chong; Helen E. Thomas; Thomas W.H. Kay Proinflammatory cytokines, including γ-interferon (IFN-γ), have been implicated in the destruction of β-cells in autoimmune diabetes. IFN-γ signaling is transient in some cell types, but there is indirect evidence that it may be prolonged in β-cells...
Published: 01 February 2002
...Helen E. Thomas; Rima Darwiche; John A. Corbett; Thomas W.H. Kay Cytokines have been implicated in pancreatic β-cell destruction leading to type 1 diabetes. In vitro, a combination of γ-interferon (IFN-γ) and interleukin-1 (IL-1) stimulate inducible nitric oxide synthase (iNOS) expression in islets...
Published: 01 February 2001
... replication, is an active component of a viral infection that stimulates antiviral responses in infected cells. Previous studies have shown that treatment of rat islets with dsRNA in combination with γ-interferon (IFN-γ) results in a nitric oxide-dependent inhibition of glucose-stimulated insulin secretion...
Ferdinando Nicoletti, Paola Zaccone, Roberto Di Marco, Gaetano Magro, Sebastiano Grasso, Franca Stivala, Giliola Calori, Lanfranco Mughini, Pier Luigi Meroni, Gianni Garotta
Published: 01 January 1998
...Ferdinando Nicoletti; Paola Zaccone; Roberto Di Marco; Gaetano Magro; Sebastiano Grasso; Franca Stivala; Giliola Calori; Lanfranco Mughini; Pier Luigi Meroni; Gianni Garotta Previous studies have shown that anti-γ-interferon (IFN-γ) antibody reduces the frequency of autoimmune IDDM in the DP-BB rat...
in Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue > Diabetes
Published: 17 July 2013
FIG. 1. Hypothetical model of macrophage–T-cell interactions in adipose tissue during obesity. Diet-induced obesity upregulates MHC-II expression on ATMs, which process the antigens (Ag) and present them to CD4 cells via MHC-TCR interaction. Obesity-induced upregulation of costimulatory molecules ... More
Sunshin Kim, Hun Sik Kim, Kun Wook Chung, Seung Hoon Oh, Jong Won Yun, Sin-Hyeog Im, Moon-Kyu Lee, Kwang-Won Kim, Myung-Shik Lee
Published: 01 October 2007
... by backcrossing and studied the in vivo role of STAT1 in β-cell death and type 1 diabetes. RESULTS— STAT1−/− islet cells were resistant to death by interferon (IFN)-γ/tumor necrosis factor (TNF)-α or IFN-γ/interleukin (IL)-1β combination. Cytochrome c translocation by IFN-γ/TNF-α...
Includes: Supplementary data
Fernanda Ortis, Najib Naamane, Daisy Flamez, Laurence Ladrière, Fabrice Moore, Daniel A. Cunha, Maikel L. Colli, Thomas Thykjaer, Kasper Thorsen, Torben F. Ørntoft, Decio L. Eizirik
Published: 23 November 2009
... gene networks that remain to be characterized. We presently utilized array analysis to define the global expression pattern of genes, including spliced variants, modified by the cytokines interleukin (IL)-1β + interferon (IFN)-γ and tumor necrosis factor (TNF)-α + IFN-γ in primary rat β-cells...
Includes: Supplementary data
WENYU GOU, JINGJING WANG, DO-SUNG KIM, LILI SONG, CHARLIE STRANGE, DAVID ADAMS, KATHERINE MORGAN, HONGJUN WANG
Published: 01 July 2018
.... Compared to mice treated with vehicle, AAT-treated mice had lower serum levels of interleukin 1 β (IL-1β), interferon- γ (IFN-γ) and interleukin 6 (IL-6), at day 1 post transplantation. To explore potential cell target(s) of AAT action, we analyzed activation of macrophages infiltrated into the liver after...
Published: 01 October 1996
... nondestructive insulitis) and in islet grafts from control phosphate-buffered saline (PBS)-injected NOD mice (β-cell destructive insulitis). Islet grafts from CFA-injected mice contained fewer CD4+ and CD8+ cells and more B cells; also fewer interferon gamma (IFN-γ), interleukin-2 (IL-2...
Zhidong Ling, Mark Van de Casteele, Jing Dong, Harry Heimberg, Jacques-Antoine Haefliger, Gérard Waeber, Frans Schuit, Daniel Pipeleers
Published: 01 October 2003
...Zhidong Ling; Mark Van de Casteele; Jing Dong; Harry Heimberg; Jacques-Antoine Haefliger; Gérard Waeber; Frans Schuit; Daniel Pipeleers We previously reported that interleukin-1β (IL-1β) alone does not cause apoptosis of β-cells, whereas when combined with γ-interferon (IFN-γ) and tumor necrosis...
Conny A. Gysemans, Laurence Ladrière, Hanne Callewaert, Joanne Rasschaert, Daisy Flamez, David E. Levy, Patrick Matthys, Décio L. Eizirik, Chantal Mathieu
Published: 01 August 2005
... resistant to interferon (IFN)-γ (studied in combination with interleukin [IL]-1β)-mediated cell death (92 ± 4% viable cells in STAT-1−/− mice vs. 56 ± 3% viable cells in wild-type controls, P ≤ 0.001) and had preserved insulin release after exposure to IL-1β and IFN-γ. Moreover, analysis...
Published: 13 August 2021
Figure 3 Modified plasmid induces a peripheral endogenous cytokine signature. A–D: Mouse IL-10, IL-2, TNF-α, and interferon-γ (IFN-γ) cytokine concentrations of NOD mice at 12 weeks of age after 8 weeks of treatment. n = 3/group. *P < 0.05; **P < 0.01. More
Published: 01 November 1985
... have cultured mouse islets in the presence of interferon-γ (IFN-γ) and subsequently examined the levels of MHC antigen by indirect immunofluorescence using monoclonal antibodies. IFN-γ induced a 10-fold increase in H-2K antigen expression on islet cells, the percentage of cells with detectable H-2K...