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igfbp-igf-binding-protein

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Journal Articles
Journal: Diabetes
Diabetes 2006;55(8):2333–2339
Published: 01 August 2006
...Abel López-Bermejo; Javad Khosravi; José Manuel Fernández-Real; Vivian Hwa; Katherine L. Pratt; Roser Casamitjana; Maria M. Garcia-Gil; Ron G. Rosenfeld; Wifredo Ricart IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) has been shown to bind both IGFs and insulin, albeit with low...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(8):2365–2370
Published: 01 August 2006
...Tero Saukkonen; Fariba Shojaee-Moradie; Rachel M. Williams; Rakesh Amin; Kevin C. Yuen; Angie Watts; Carlo L. Acerini; A. Margot Umpleby; David B. Dunger Recombinant human IGF-I (rhIGF-I) complexed with its natural binding protein IGF-binding protein (IGFBP)-3 (rhIGF-I/IGFBP-3) is a novel...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(2):285–294
Published: 01 February 2007
... adipocytes contributes to the development of obesity in mammals. IGF-I is a potent mitogen and important stimulus for adipocyte differentiation. The biological actions of IGFs are closely regulated by a family of IGF-binding proteins (IGFBPs), which exert predominantly inhibitory effects. IGFBP-2...
Journal Articles
Journal: Diabetes
Diabetes 1999;48(2):377–382
Published: 01 February 1999
... characterized by growth retardation, hyperphagia, hyperglycemia, increased serum GH levels, reduced serum IGF-I, IGF-binding protein (IGFBP)-3, and liver IGF-I levels, increased kidney IGF-I, renal/glomerular hypertrophy, and increased UAE when compared with nondiabetic animals. No differences were seen between...
Journal Articles
Journal: Diabetes
Diabetes 2000;49(3):457–465
Published: 01 March 2000
...P A Crossey; J S Jones; J P Miell The insulin/IGF binding protein-1 (IGFBP-1) axis is important in coordinating insulin- and IGF-mediated regulation of glucose metabolism and glycemia. Dysregulation of the axis may play a role in the pathophysiology of disorders of insulin deficiency and resistance...
Journal Articles
Journal: Diabetes
Diabetes 1997;46(11):1881–1887
Published: 01 November 1997
... of an antibody, α-p60, directed against the p60/OST protein named AGE-receptor 1 (AGE-R1), or normal control (pre-immune) serum. The mRNA and/or protein levels of IGF-I, IGF-II, IGF receptors, IGF binding proteins (IGFBPs), TGF-β1 and the ECM components fibronectin, laminin, and collagen IV were measured...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(10):2788–2796
Published: 01 October 2006
...Radhika H. Muzumdar; Xiaohui Ma; Sigal Fishman; Xiaoman Yang; Gil Atzmon; Patricia Vuguin; Francine H. Einstein; David Hwang; Pinchas Cohen; Nir Barzilai IGF-I is recognized as an insulin sensitizer at the liver and muscle, while recent evidence suggests that IGF-binding protein (IGFBP)-3 acts...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(2):392–397
Published: 01 February 2002
... hormone, and IGFs and their IGF binding proteins (IGFBPs) could be instrumental in this anomaly. Although it confirms that GK fetuses are hypoinsulinemic despite enhanced plasma glucose level due to maternal hyperglycemia, the present study shows for the first time that IGF-2 expression in the liver...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(12):3547–3553
Published: 01 December 2005
... be accounted for using two of the “reno-protective” SNPs, with other SNPs adding little extra information. One of these two SNPs was the nonsynonymous mutation in exon 4, lying close to the integrin-binding RGD motif, which is thought to affect tissue delivery of IGF-I by IGF-binding protein 1 (IGFBP-1...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(8):2075–2082
Published: 01 August 2003
...Stephen B. Wheatcroft; Mark T. Kearney; Ajay M. Shah; David J. Grieve; Ian L. Williams; John P. Miell; Paul A. Crossey IGFs and their binding proteins (IGFBPs) play a significant role in metabolic regulation, and there is growing evidence that they also exert important vascular effects. IGFBP-1...
Journal Articles
Journal: Diabetes
Diabetes 1992;41(4):499–507
Published: 01 April 1992
..., and to specific binding proteins (IGFBPs), which modulate its actions. To explore the nature and extent of IGF-I binding in the kidney, in vitro autoradiography was used to map the distribution of IGF binding in control and diabetic rat kidney. Specificity studies were performed with increasing concentrations...
Journal Articles
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1412-P
Published: 01 July 2018
... is known about its role in the development of gestational diabetes mellitus (GDM). The aim of our study was to determine serum IGF-1, IGF-2 and selected IGF binding protein (IGFBP) levels and their mRNA expression in subcutaneous (SAT) and visceral adipose tissue (VAT) and placenta in the context...
Journal Articles
Journal: Diabetes
Diabetes 2012;61(9):2248–2254
Published: 17 August 2012
... with insulin. Laboratory models suggest that IGF-I and its binding proteins IGFBP-1 and IGFBP-2 have potentially beneficial effects on diabetes risk, whereas IGFBP-3 may have adverse effects. We therefore conducted a prospective nested case-control investigation of incident diabetes (n = 742 case...
Journal Articles
Journal: Diabetes
Diabetes 2016;65(11):3495–3504
Published: 28 July 2016
..., and 33–39. Conditional logistic regression was used, adjusting for major risk factors including prepregnancy BMI. Plasma IGF-I and IGF binding protein 3 (IGFBP-3) concentrations and molar ratio of IGF-I to IGFBP-3 increased, whereas IGFBP-2 decreased throughout pregnancy. At gestational weeks 10–14, both...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 1998;47(6):924–930
Published: 01 June 1998
... conclude that the well-known inhibitory effect of octreotide on the early increase in renal IGF-I concentration and renal size in diabetes may be mediated through a direct effect on renal IGFBP-1 levels. Octreotide Prevents the Early Increase in Renal Insulin-Like Growth Factor Binding Protein 1...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(1):32–38
Published: 01 January 2001
...Keiji Sakai; A. Joseph D'Ercole; Liam J. Murphy; David R. Clemmons Insulin-like growth factor binding protein (IGFBP)-1 has been shown to alter cellular responses to insulin-like growth factor 1 (IGF-1). Human IGFBP-1 undergoes serine phosphorylation, and this enhances both its affinity for IGF-1...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(12):1420–1425
Published: 01 December 1995
...Buel D Rodgers; Alison M Strack; Mary F Dallman; Linda Hwa; Charles S Nicoll The experiments reported herein were conducted to determine how corticosterone regulates growth and plasma insulin-like growth factor (IGF) I and IGF-binding protein (IGFBP) concentrations in normal and streptozotocin (STZ...
Journal Articles
Journal: Diabetes
Diabetes 2020;69(3):413–423
Published: 11 December 2020
... IGF1 and IGF2, promote glucose metabolism, with their availability regulated by IGF-binding proteins (IGFBPs). We hypothesized that IGF1 and IGF2 levels, or their bioavailability, are reduced during type 1 diabetes development. Total serum IGF1, IGF2, and IGFBP1–7 levels were measured in an age-matched...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2017;66(2):287–299
Published: 10 November 2016
... proteins (IGFBPs) comprise a family of proteins that bind insulin-like growth factors (IGFs) with high affinity ( 6 ). Several IGFBPs possess distinctive structural motifs that allow interactions with cells or extracellular matrices and confer the ability of these proteins to signal independently of IGF...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 1992;41(7):835–842
Published: 01 July 1992
...B C Villafuerte; S Goldstein; D G Robertson; C -I Pao; L J Murphy; L S Phillips The insulinlike growth factors (IGFs) circulate in association with insulinlike growth factor binding proteins (IGFBPs) that modulate IGF action, but mechanisms of IGFBP regulation are poorly understood. We investigated...