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ivgtt-intravenous-glucose-tolerance-test

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Progression of the type 1 diabetes disease process. This is a cellular auto...
Published: 01 January 2011
FIG. 1. Progression of the type 1 diabetes disease process. This is a cellular autoimmune process occurring in individuals with a genetic predisposition to the disease, presumably triggered by some environmental factor. Humoral antibodies indicate that the disease process is underway, and there is then progressive impairment of β-cell function manifested by progressive deterioration of glucose metabolism. The time frame is variable, so the x-axis is dimensionless. IAA, insulin autoantibody; ICA, islet cell antibody; IVGTT, intravenous glucose tolerance test; OGTT, oral glucose tolerance test. FIG. 1. Progression of the type 1 diabetes disease process. This is a cellular autoimmune process occurring in individuals with a genetic predisposition to the disease, presumably triggered by some environmental factor. Humoral antibodies indicate that the disease process is underway, and there is then progressive impairment of β-cell function manifested by progressive deterioration of glucose metabolism. The time frame is variable, so the x-axis is dimensionless. IAA, insulin autoantibody; ICA, islet cell antibody; IVGTT, intravenous glucose tolerance test; OGTT, oral glucose tolerance test. More
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Abbreviated summary of published studies relating serum ceramides to variou...
Published: 13 July 2018
Figure 1 Abbreviated summary of published studies relating serum ceramides to various measures of cardiometabolic disease. Upper panel denotes sites where the studies were performed. Lower panel denotes study population, number of subjects, lipids analyzed, and clinical end points assessed. IVGTT,... More
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Salsalate prevents HFD-induced deterioration of <span class="search-highlight">glucose</span> and TG metabolism i...
Published: 04 December 2014
Figure 2 Salsalate prevents HFD-induced deterioration of glucose and TG metabolism in E3L.CETP mice fed an HFD. A–G: The 10-week-old male E3L.CETP mice were fed an HFD without (open bars/circles) or with (closed bars/circles) salsalate for 12 weeks. Blood samples from mice fasted for 6 h were collected by tail vein bleeding at different time points, and plasma glucose (A), insulin (B), TC (E), and TG (F) levels were determined. After 4 weeks, mice fasted for 6 h were injected intravenously with glucose, and additional blood samples were taken at 5, 15, 30, 60, 90, and 120 min after injection (C and D). A clearance experiment was performed in which 6 h–fasted mice were intravenously injected with [3H]TO-labeled lipoprotein-like emulsion particles. G: After 15 min, mice were killed, and uptake of [3H]TO-derived activity was determined in the organs. Values represent means ± SEM (n = 9–10). *P < 0.05, **P < 0.01 vs. control. ivGTT, intravenous glucose tolerance test; sWAT, subcutaneous WAT; vWAT, visceral WAT. Figure 2. Salsalate prevents HFD-induced deterioration of glucose and TG metabolism in E3L.CETP mice fed an HFD. A–G: The 10-week-old male E3L.CETP mice were fed an HFD without (open bars/circles) or with (closed bars/circles) salsalate for 12 weeks. Blood samples from mice fasted for 6 h were collected by tail vein bleeding at different time points, and plasma glucose (A), insulin (B), TC (E), and TG (F) levels were determined. After 4 weeks, mice fasted for 6 h were injected intravenously with glucose, and additional blood samples were taken at 5, 15, 30, 60, 90, and 120 min after injection (C and D). A clearance experiment was performed in which 6 h–fasted mice were intravenously injected with [3H]TO-labeled lipoprotein-like emulsion particles. G: After 15 min, mice were killed, and uptake of [3H]TO-derived activity was determined in the organs. Values represent means ± SEM (n = 9–10). *P < 0.05, **P < 0.01 vs. control. ivGTT, intravenous glucose tolerance test; sWAT, subcutaneous WAT; vWAT, visceral WAT. More
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<em>ADAMTS9</em> rs4607103 is associated with decreased insulin sen...
Published: 09 January 2019
Figure 1 ADAMTS9 rs4607103 is associated with decreased insulin sensitivity, differential ADAMTS9 expression, and insulin signaling. A: Meta-analysis of estimates of insulin sensitivity (fixed-effects model: β = −0.080 standard deviation [95% CI −0.14 to −0.020]; P = 0.0090). B: ADAMTS9 mRNA expression by quantitative PCR in the Danish Family Study (first-degree relatives of patients with type 2 diabetes) divided by genotype (CC n = 45, CT n = 31, TT n = 4; P = 0.008). C and D: C allele = rs4607103 risk allele; T allele = other allele. Danish nondiabetic twin cohort divided into genotypes (CC n = 108, CT n = 67, TT n = 7) after insulin stimulation. Akt Thr308 phosphorylation (P = 0.04) (C) and glycogen synthase (GS) activity (P = 0.06) (D) are shown. A mixed linear model was used assuming an additive genetic effect. P values are adjusted for sex, age, BMI, and family relationship. See also Supplementary Tables 1 – 3 . A.U., arbitrary units; IVGTT, intravenous glucose tolerance test. Figure 1. ADAMTS9 rs4607103 is associated with decreased insulin sensitivity, differential ADAMTS9 expression, and insulin signaling. A: Meta-analysis of estimates of insulin sensitivity (fixed-effects model: β = −0.080 standard deviation [95% CI −0.14 to −0.020]; P = 0.0090). B: ADAMTS9 mRNA expression by quantitative PCR in the Danish Family Study (first-degree relatives of patients with type 2 diabetes) divided by genotype (CC n = 45, CT n = 31, TT n = 4; P = 0.008). C and D: C allele = rs4607103 risk allele; T allele = other allele. Danish nondiabetic twin cohort divided into genotypes (CC n = 108, CT n = 67, TT n = 7) after insulin stimulation. Akt Thr308 phosphorylation (P = 0.04) (C) and glycogen synthase (GS) activity (P = 0.06) (D) are shown. A mixed linear model was used assuming an additive genetic effect. P values are adjusted for sex, age, BMI, and family relationship. See also Supplementary Tables 1–3. A.U., arbitrary units; IVGTT, intravenous glucose tolerance test. More
Journal Articles
Journal: Diabetes
Diabetes 1989;38(Supplement_1):101–103
Published: 01 January 1989
...% in the mean 24-h urinary C-peptide excretion in 21 donors. Including the studies performed postdonation, 11 of 31 (35%) donors developed an abnormal OGTT result. In a retrospective analysis, preoperative results of intravenous glucose tolerance tests (IVGTTs) and cortisonestimulated OGTTs were found...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(12):1433–1437
Published: 01 December 1995
..., GLP-I increases glucose disposal independent of its effects on islet hormone secretion. To test the hypothesis that this extrapancreatic effect of GLP-I on glucose disposition is present at physiological levels of GLP-I, we performed intravenous glucose tolerance tests (IVGTTs) 1 h after the following...
Journal Articles
Journal: Diabetes
Diabetes 1995;44(9):1021–1028
Published: 01 September 1995
...-cell dysfunction, we performed sequential intravenous glucose tolerance tests (IVGTTs) on 81 islet cell antibody (ICA)-positive and/or insulin autoantibody-positive healthy siblings of children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). A lower glucose disappearance rate...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(2):514–517
Published: 01 February 2008
...-stimulated insulin release, a subgroup of 758 subjects underwent an intravenous glucose tolerance test (IVGTT). RESULTS— SNPs rs1111875 and rs7923837 were not associated with anthropometric data (age, weight, height, BMI, body fat, and waist and hip circumference). After adjustment for center, family...
Includes: Supplementary data
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Plasma human growth hormone (hGH) (<em>A</em>), glucagon (<em>B</em>...
Published: 14 June 2014
Figure 4 Plasma human growth hormone (hGH) (A), glucagon (B), cortisol (C), and free fatty acid (FFA) (D) concentrations during a 210-min infusion of AG, UAG, AG+UAG, or saline in healthy men and women. An intravenous glucose tolerance test (IVGTT) was performed between 30 and 210 min. Intravenous glucose was administered after 30 min of ghrelin or saline infusion. Insulin at 0.025 units/kg was given as a short intravenous infusion between 50 and 55 min. The insets show the respective areas under the curve (AUC). *P < 0.05; **P < 0.01; ***P < 0.001; a, AG vs. saline; b, AG+UAG vs. saline. Figure 4. Plasma human growth hormone (hGH) (A), glucagon (B), cortisol (C), and free fatty acid (FFA) (D) concentrations during a 210-min infusion of AG, UAG, AG+UAG, or saline in healthy men and women. An intravenous glucose tolerance test (IVGTT) was performed between 30 and 210 min. Intravenous glucose was administered after 30 min of ghrelin or saline infusion. Insulin at 0.025 units/kg was given as a short intravenous infusion between 50 and 55 min. The insets show the respective areas under the curve (AUC). *P < 0.05; **P < 0.01; ***P < 0.001; a, AG vs. saline; b, AG+UAG vs. saline. More
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Plasma AG (<em>A</em>) and UAG (<em>B</em>) levels during c...
Published: 14 June 2014
Figure 1 Plasma AG (A) and UAG (B) levels during continuous intravenous infusions (0 to 210 min) of AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG (1 µg/kg/h) and UAG (4 µg/kg/h), or saline in healthy men and women. A 180-min frequently sampled intravenous glucose tolerance test (IVGTT) was conducted between 30 and 210 min after the ghrelin infusion began. The area under the curve (AUC) is shown for AG (C) and UAG (D). Figure 1. Plasma AG (A) and UAG (B) levels during continuous intravenous infusions (0 to 210 min) of AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG (1 µg/kg/h) and UAG (4 µg/kg/h), or saline in healthy men and women. A 180-min frequently sampled intravenous glucose tolerance test (IVGTT) was conducted between 30 and 210 min after the ghrelin infusion began. The area under the curve (AUC) is shown for AG (C) and UAG (D). More
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(5):714–720
Published: 01 May 1998
...G M Steil; K Rebrin; S D Mittelman; R N Bergman The contribution of portal insulin delivery to the disappearance of glucose administered intravenously was assessed in the present study. Paired insulin-modified intravenous glucose tolerance tests (IVGTTs) were performed in dogs in which insulin...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(11):1572–1579
Published: 01 November 1996
... of may be a manifestation of the P-cell defect that pre- developing NIDDM within 5 years. After baseline oral disposes the women to NIDDM. The overall pattern of (OGTT) and intravenous (IVGTT) glucose tolerance response to troglitazone in our high-risk patients indi- testing, subjects were assigned...
Journal Articles
Journal: Diabetes
Diabetes 1996;45(5):552–556
Published: 01 May 1996
... pmol · kg−1 · h−1) or saline intravenously. After 30 min, a 25-g intravenous glucose tolerance test (IVGTT) was carried out, and plasma concentrations of glucose, insulin, glucagon, and GLP-I were measured during the following 2 h. IVGTT together with GLP-I infusion significantly...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S92–S96
Published: 01 December 2004
... glucose (1 g/kg) tolerance test (IVGTT). It was found that transgenic mice had an abolished insulin response in association with severe glucose intolerance. In other tests, the 5-min insulin response to intravenous arginine was impaired by 79% (P = 0.032) and the 15-min insulin response...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(5):1201–1207
Published: 01 May 2004
...) and β-cell function from a single test. We compared the model-derived meal indexes with analogous indexes obtained from an intravenous glucose tolerance test (IVGTT) and hyperglycemic clamp (HGC) in 17 nondiabetic subjects (14 men, 3 women, aged 50 ± 2 years [mean ± SE], BMI 25.0 ± 0.7 kg/m2...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(4):1074–1079
Published: 01 April 2006
... tolerance tests (OGTTs) and intravenous glucose tolerance tests (IVGTTs) were performed at 15-month intervals for up to 5 years or until fasting plasma glucose exceeded 140 mg/dl in Hispanic women with recent gestational diabetes. Data were analyzed 1) to compare changes in insulin sensitivity, β...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(4):710–719
Published: 01 April 2001
... transplantation, and long-term complications related to immunosuppression therapy and diabetes were noted. Insulin secretion, both acute and over 30 min, was determined after intravenous glucose tolerance tests (IVGTTs). The median follow-up was 10.2 months (CI 6.5–17.4), and the longest was 20 months. Glucose...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(5):1098–1103
Published: 01 May 2003
... bariatric surgery in patients with morbid obesity and type 2 diabetes could restore euglycemia and normal AIR to an intravenous glucose tolerance test (IVGTT). We studied 25 morbidly obese patients—12 with type 2 diabetes, 5 with impaired glucose tolerance, and 8 with normal glucose tolerance (NGT)—before...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(5):1070–1081
Published: 01 May 1999
... the accuracy of the estimates of glucose effectiveness from the Cold-MM and the single-compartment tracer minimal model (Hot-MM). Paired labeled intravenous glucose tolerance tests (IVGTTs) were performed in each of six C-peptide-negative type 1 diabetic subjects. Two different insulin infusion protocols were...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(6):926–935
Published: 01 June 2000
..., coefficient of variation; EGO, endoge- nous glucose output; FFA, free fatty acid; GFAT, glutamine fructose-6-phos- phate amidotransferase; GlcN, glucosamine; GSIS, glucose-stimulated insulin secretion; HPLC, high-performance liquid chromatography; IVGTT, intravenous glucose tolerance test; RRI, readily...