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katp-channel-atp-sensitive-k-channel

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Journal Articles
Journal: Diabetes
Diabetes 2005;54(11):3065–3072
Published: 01 November 2005
...Joseph C. Koster; M. Alan Permutt; Colin G. Nichols The ATP-sensitive K+ channel (KATP channel) senses metabolic changes in the pancreatic β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When KATP channels open, β...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(5):1592–1597
Published: 01 May 2005
...Li Li; Yun Shi; Xueren Wang; Weiwei Shi; Chun Jiang ATP-sensitive K+ channels (KATP channels) play an important role in glucose homeostasis. A single nucleotide polymorphism (SNP) in the Kir6.2 subunit causes a point mutation of Glu23 to lysine and reduces the ATP sensitivity...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S59–S62
Published: 01 December 2004
...Tadao Shibasaki; Yasuhiro Sunaga; Susumu Seino Intracellular ATP, cAMP, and Ca2+ are major signals involved in the regulation of insulin secretion in the pancreatic β-cell. We recently found that the ATP-sensitive K+ channel (KATP channel) as an ATP sensor, cAMP...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S165–S168
Published: 01 December 2004
...Xiao-Ke Liu; Satsuki Yamada; Garvan C. Kane; Alexey E. Alekseev; Denice M. Hodgson; Fearghas O’Cochlain; Arshad Jahangir; Takashi Miki; Susumu Seino; Andre Terzic Metabolic-sensing ATP-sensitive K+ channels (KATP channels) adjust membrane excitability to match cellular...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(5):1357–1362
Published: 01 May 2007
... of the sulfonylurea receptor (SUR)1, the regulatory subunit of the pancreatic ATP-sensitive K+ channel (KATP channel). RESEARCH DESIGN AND METHODS— The effects of L225P on the properties of recombinant KATP channels in transfected COS cells were assessed by patch-clamp experiments...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(6):1731–1737
Published: 01 June 2006
...Peter Proks; Christophe Girard; Halvor Bævre; Pål R. Njølstad; Frances M. Ashcroft Heterozygous mutations in the human Kir6.2 gene (KCNJ11), the pore-forming subunit of the ATP-sensitive K+ channel (KATP channel), cause neonatal diabetes. To date, all mutations...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S123–S127
Published: 01 December 2004
...Jeff D. Campbell; Peter Proks; Jonathan D. Lippiat; Mark S.P. Sansom; Frances M. Ashcroft The ATP-sensitive K+ channel (KATP channel) couples glucose metabolism to insulin secretion in pancreatic β-cells. It is comprised of sulfonylurea receptor (SUR)-1 and Kir6.2 proteins...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(11):3075–3082
Published: 01 November 2006
...Andrei I. Tarasov; Hannah J. Welters; Sabine Senkel; Gerhart U. Ryffel; Andrew T. Hattersley; Noel G. Morgan; Frances M. Ashcroft ATP-sensitive K+ channels (KATP channels) couple β-cell metabolism to electrical activity and thereby play an essential role in the control...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(suppl_1):S96–S98
Published: 01 February 2002
... Ca2+ concentration, which is due to the electrophysiological events that originate in closure of the ATP-sensitive K+ (KATP) channel, most likely triggers the first phase. The second phase is produced by gradual augmentation and potentiation of Ca2+-triggered...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(9):2446–2454
Published: 01 September 2006
...Andrei I. Tarasov; Christophe A.J. Girard; Frances M. Ashcroft ATP-sensitive K+ channels (KATP channels) couple cell metabolism to electrical activity and thereby to physiological processes such as hormone secretion, muscle contraction, and neuronal activity. However...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S113–S122
Published: 01 December 2004
...Andrei Tarasov; Julien Dusonchet; Frances Ashcroft Closure of ATP-sensitive K+ channels (KATP channels) is a key step in glucose-stimulated insulin secretion. The precise mechanism(s) by which glucose metabolism regulates KATP channel activity, however, remains...
Journal Articles
Journal: Diabetes
Diabetes 1993;42(10):1446–1453
Published: 01 October 1993
..., we studied the properties of ATP-sensitive K+ channels, the inhibition of which is a key step of insulin secretion induced by fuel substrates, using the patch-clamp technique. The glucose-sensitivity of KATP channels was considerably reduced in GK rats. However, the inhibitory effects of ATP...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S176–S180
Published: 01 December 2004
...Kohtaro Minami; Takashi Miki; Takashi Kadowaki; Susumu Seino ATP-sensitive K+ channels (KATP channels) are present in various tissues, including pancreatic β-cells, heart, skeletal muscles, vascular smooth muscles, and brain. KATP channels are hetero-octameric...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(4):1115–1119
Published: 01 April 2008
... nonautoimmune insulin deficiency diagnosed in the first months of life. Several genes, including KCNJ11 and ABCC8, which encode the two subunits of the ATP-sensitive K+ channel (KATP channel) can cause PND. Mutations in the insulin (INS) gene have been recently...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(2):383–393
Published: 01 February 2005
...Sofija Jovanović; Aleksandar Jovanović Because we were interested in assessing glucose-mediated regulation of the activity of sarcolemmal ATP-sensitive K+ channels (KATP channels) (which are closed by physiological levels of intracellular ATP and serve to couple...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(11):2957–2964
Published: 01 November 2006
...Joseph C. Koster; Maria S. Remedi; Ricard Masia; Brian Patton; Ailing Tong; Colin G. Nichols Glucose metabolism in pancreatic β-cells elevates cytoplasmic [ATP]/[ADP], causing closure of ATP-sensitive K+ channels (KATP channels), Ca2+ entry through voltage-dependent...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(10):2852–2858
Published: 01 October 2005
...Chia-Wei Lin; Feifei Yan; Satoko Shimamura; Sebastian Barg; Show-Ling Shyng ATP-sensitive K+ channels (KATP channels) of pancreatic β-cells play key roles in glucose-stimulated insulin secretion by linking metabolic signals to cell excitability. Membrane phosphoinositides...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(suppl_3):S443–S447
Published: 01 December 2002
..., glucagon-like peptide-1; GMP-PNP, guanosine 5′-[β,γ-imido]triphosphate; GSIS, glucose-stimulated insulin secretion; KATP channel, ATP-sensitive K+ channel; KCa channel, Ca2+-sensitive K+ channel; KV channel, voltage-dependent K...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(1):259–263
Published: 01 January 2008
... the whole of the pancreas and most commonly results from recessive ATP-sensitive K+ channel (KATP channel) mutations. Focal lesions are the consequence of somatic uniparental disomy for a paternally inherited KATP channel mutation with enlargement of the β-cell nuclei...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(suppl_3):S363–S367
Published: 01 December 2002
...Christina Schwanstecher; Bettina Neugebauer; Miriam Schulz; Mathias Schwanstecher E23K, a common polymorphism in the pore-forming subunit KIR6.2 of pancreatic β-cell ATP-sensitive K+ (KATP) channels, is functionally relevant and thus might play a major role...