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lada-latent-autoimmune-diabetes-adults

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Journal Articles
Journal: Diabetes
Diabetes 2020;69(4):624–633
Published: 23 January 2020
...Anne Jörns; Dirk Wedekind; Joachim Jähne; Sigurd Lenzen Approximately 10% of patients with type 2 diabetes suffer from latent autoimmune diabetes in adults (LADA). This study provides a systematic assessment of the pathology of the endocrine pancreas of patients with LADA and for comparison...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1634-P
Published: 01 June 2020
...MICHELLE N. LEE Introduction: Latent autoimmune diabetes in Adults (LADA) represents up to 14% of adult diabetes. Compared to type 2 diabetes mellitus (T2DM) patients, LADA is believed to be diagnosed more acutely in younger patients with a lower body mass index (BMI), worse hemoglobin A1Cs (HbA1C...
Images
<em>A</em>: Representation of ZnT8 with predicted positions of amin...
Published: 15 September 2014
Figure 1 A: Representation of ZnT8 with predicted positions of amino acid residues for transmembrane, cytosolic, and luminal/extracellular segments (TMHMM v2.0). Four immunogenic epitopes are marked (not drawn to scale). Synopsis of T-cell epitopes (B) and B-cell epitopes (C) on ZnT8. Ext, extracellular; LADA, latent autoimmune diabetes of adult; Sp, signal peptide; TM, transmembrane. Figure 1. A: Representation of ZnT8 with predicted positions of amino acid residues for transmembrane, cytosolic, and luminal/extracellular segments (TMHMM v2.0). Four immunogenic epitopes are marked (not drawn to scale). Synopsis of T-cell epitopes (B) and B-cell epitopes (C) on ZnT8. Ext, extracellular; LADA, latent autoimmune diabetes of adult; Sp, signal peptide; TM, transmembrane. More
Meeting Abstracts
Journal: Diabetes
Diabetes 2021;70(Supplement_1):168-LB
Published: 01 June 2021
... decarboxylase autoantibody (GADA) was screened in 1508 phenotypic T2DM subjects and those with positive GADA were defined as LADY. Metabolic status, insulin resistance and residual β-cell function of LADY were investigated and compared with other 658 adult-onset latent autoimmune diabetes (LADA) patients...
Journal Articles
Journal: Diabetes
Diabetes 2020;69(10):2037–2047
Published: 26 August 2020
..., clinically resemble T2D patients by not requiring insulin treatment, yet they have immunogenetic markers associated with T1D. Such a slowly evolving form of autoimmune diabetes, described as latent autoimmune diabetes of adults (LADA), accounts for 2–12% of all patients with adult-onset diabetes, though...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(suppl_2):S68–S72
Published: 01 December 2005
...Gunnar Stenström; Anders Gottsäter; Ekaterine Bakhtadze; Bo Berger; Göran Sundkvist Latent autoimmune diabetes in adults (LADA) is a disorder in which, despite the presence of islet antibodies at diagnosis of diabetes, the progression of autoimmune β-cell failure is slow. LADA patients...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(5):1276–1283
Published: 01 May 2008
... patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti–IA-2 immune response in Caucasian LADA patients, identifying the most sensitive construct to evaluate IA-2 immunoreactivity and comparing...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):253-OR
Published: 01 June 2019
...ERNESTO MADDALONI; RUTH L. COLEMAN; RURY R. HOLMAN Background: Latent Autoimmune Diabetes of Adults (LADA) is a mild form of autoimmune diabetes which can be identified in 3-12% of adults who have a clinical diagnosis of T2D. LADA differs in genetic and clinical features with T2D, but whether...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1076-P
Published: 01 June 2020
...LEI ZHANG; WEI MENG; SHUFANG CHEN; YUXIU YANG; JUN WANG; YANHU DONG Objectives: Adult-onset autoimmune diabetes, defined as having latent autoimmune diabetes in adults (LADA), is characterized by a less intensive autoimmune process, in which a lymphocytic infiltration of the exocrine pancreas...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1147-P
Published: 01 June 2019
...LEI ZHANG; JUN WANG; NA WANG; YUXIU YANG; XIAOYAN YIN; YANHU DONG Adult-onset autoimmune diabetes, defined as having latent autoimmune diabetes in adults (LADA), is characterized by a less intensive autoimmune process, in which a lymphocytic infiltration of the exocrine pancreas is involved...
Journal Articles
Journal: Diabetes
Diabetes 2010;59(1):302–310
Published: 15 October 2009
...Elin Pettersen; Frank Skorpen; Kirsti Kvaløy; Kristian Midthjell; Valdemar Grill OBJECTIVE Previous studies have indicated that the latent autoimmune diabetes in adults (LADA) phenotype is heterogeneous and that LADA patients share features of type 1 and type 2 diabetes in various proportions. We...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2013;62(2):543–550
Published: 17 January 2013
...Zhiguang Zhou; Yufei Xiang; Linong Ji; Weiping Jia; Guang Ning; Gan Huang; Lin Yang; Jian Lin; Zhenqi Liu; William A. Hagopian; R. David Leslie; on behalf of the LADA China Study Group Adult non–insulin requiring diabetes includes latent autoimmune diabetes of adults (LADA), distinguished from type...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):196-LB
Published: 01 July 2018
...SAHAR J. IQBAL Latent Autoimmune Diabetes of the Adult (LADA) is a slowly progressive form of diabetes associated with autoantibody positivity. LADA shares characteristics with type 1 and 2 diabetes (T1D, T2D) but is often misdiagnosed as T2D. Epidemiologic data shows patients with LADA may account...
Meeting Abstracts
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1289-P
Published: 01 June 2022
...SARA VELAYATI; MICHAEL SHANIK; ISABELA J. ROMAO Introduction: Latent autoimmune diabetes in adults (LADA) is atypical heterogenic diabetes that is frequently misdiagnosed as type 2 diabetes (T2DM) . LADA can demonstrate features of type 1 or T2DM.1 The diagnosis of LADA is well...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(10):2768–2773
Published: 01 October 2008
... of inflammatory gene expression in monocytes of patients with type 1 diabetes (juvenile onset, n = 30; adult onset, n = 30) and latent autoimmune diabetes of the adult (LADA) (n = 30) (controls subjects, n = 49; type 2 diabetic patients, n = 30) using quantitative PCR...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1698-P
Published: 01 July 2018
...ZHIGUANG ZHOU; XIAJIE SHI; PEILIN ZHENG; GAN HUANG; YANFEI WANG; CHAO DENG Objective: This study aimed to investigate the prevalence of the newly-identified islet autoantibody, tetraspanin 7 autoantibody (TSPAN7A) in Chinese type 1 diabetes (T1D) and Latent Autoimmune Diabetes in Adults (LADA...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1590-P
Published: 01 July 2018
...ANDREA LUK; ERIC S. LAU; CADMON K.P. LIM; ELAINE CHOW; RONALD C. MA; ALICE P. KONG; JULIANA C. CHAN Objectives: Few studies have examined the progression to chronic complications in patients with latent autoimmune diabetes in adults (LADA). We compared incidence of cardiovascular-renal diseases...
Journal Articles
Journal: Diabetes
Diabetes 2017;66(4):806–814
Published: 02 December 2016
...Mahmoud Al-Majdoub; Arslan Ali; Petter Storm; Anders H. Rosengren; Leif Groop; Peter Spégel Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)–positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2380-PUB
Published: 01 July 2018
...PARIKSHIT J. GOSWAMI; BANSHI D. SABOO; KAUSHAL K. PATEL; BHAVESH N. PATEL; NAVNEET WADHWA Patients with diagnosis of T2DM may also have islet antibodies typically associated with T1DM, as Latent Autoimmune Diabetes of the Adult (LADA). More than 90% of LADA patients in have antibodies against...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(5):1433–1437
Published: 01 May 2008
...Camilla Cervin; Valeriya Lyssenko; Ekaterine Bakhtadze; Eero Lindholm; Peter Nilsson; Tiinamaija Tuomi; Corrado M. Cilio; Leif Groop OBJECTIVE— Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more...