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lpl-lipoprotein-lipase

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Radiolabeled species in metabolic imaging of DFA metabolism with <sup>18</sup>...
Published: 17 June 2015
Figure 1 Radiolabeled species in metabolic imaging of DFA metabolism with 18F-FTHA. LPL, lipoprotein lipase. βOX, beta oxidation. Figure 1. Radiolabeled species in metabolic imaging of DFA metabolism with 18F-FTHA. LPL, lipoprotein lipase. βOX, beta oxidation. More
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Potential role of GLP-1, GLP-2, insulin, and glucagon in regulating the pos...
Published: 17 January 2013
FIG. 1. Potential role of GLP-1, GLP-2, insulin, and glucagon in regulating the postprandial metabolism of chylomicron and VLDL particles. GLP-1 and GLP-2 have opposing effects on chylomicron metabolism in response to dietary fat load. GLP-1 inhibits intestinal chylomicron biogenesis, stimulates i... More
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<em>A</em>: mRNA expression of degs1 in 3T3-L1 cells during adipocy...
Published: 28 October 2014
Figure 3 A: mRNA expression of degs1 in 3T3-L1 cells during adipocyte differentiation. B: Lipid accumulation at day 9 of differentiation, Oil Red O staining. C: mRNA expression of PREF1 in WT and degs1 KD cells during differentiation. D: mRNA expression of genes involved in adipocyte differentiation and lipid accumulation. Values are the mean ± SEM of three separate experiments performed in triplicate. FAS, fatty acid synthase; Insig, insulin-induced gene; LPL, lipoprotein lipase. *P < 0.05. Figure 3. A: mRNA expression of degs1 in 3T3-L1 cells during adipocyte differentiation. B: Lipid accumulation at day 9 of differentiation, Oil Red O staining. C: mRNA expression of PREF1 in WT and degs1 KD cells during differentiation. D: mRNA expression of genes involved in adipocyte differentiation and lipid accumulation. Values are the mean ± SEM of three separate experiments performed in triplicate. FAS, fatty acid synthase; Insig, insulin-induced gene; LPL, lipoprotein lipase. *P < 0.05. More
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Nrf2 activation reduces lipid deposition and lipogenic gene expression in W...
Published: 15 November 2012
FIG. 4. Nrf2 activation reduces lipid deposition and lipogenic gene expression in WAT of Lepob/ob mice. A: TG and FFA levels in epididymal pad from 8-week-old male mice (n = 4 to 8). B: Total RNA was extracted and gene expression was analyzed by quantitative real-time PCR from epididymal pad of 8-week-old male mice (n = 5 to 8). $P < 0.05, Keap1-KD mice compared with WT mice; #P < 0.05, OB mice compared with WT mice; *P < 0.05, OBKeap1-KD mice compared with OB mice. Irs, insulin receptor substrate; LPL, lipoprotein lipase; MGL, monoacylglycerol; HSL, hormone sensitive lipase. FIG. 4. Nrf2 activation reduces lipid deposition and lipogenic gene expression in WAT of Lepob/ob mice. A: TG and FFA levels in epididymal pad from 8-week-old male mice (n = 4 to 8). B: Total RNA was extracted and gene expression was analyzed by quantitative real-time PCR from epididymal pad of 8-week-old male mice (n = 5 to 8). $P < 0.05, Keap1-KD mice compared with WT mice; #P < 0.05, OB mice compared with WT mice; *P < 0.05, OBKeap1-KD mice compared with OB mice. Irs, insulin receptor substrate; LPL, lipoprotein lipase; MGL, monoacylglycerol; HSL, hormone sensitive lipase. More
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Real-time PCR analysis of the modified genes. The PCR results expressed are...
Published: 01 December 2003
FIG. 3. Real-time PCR analysis of the modified genes. The PCR results expressed are given as the means ± SE of three to four comparisons in GDM versus control subjects (gray bars). Black bars represent the average fold change obtained with microarray analysis. All values are presented as relative ... More
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Gene expression levels in epididymal adipose tissue (<em>A</em>) an...
Published: 02 December 2015
Figure 5 Gene expression levels in epididymal adipose tissue (A) and in gastrocnemius muscle (B). *P < 0.05, **P < 0.01. n = 4–13 per group. Acadm, medium-chain acyl-CoA dehydrogenase; Acadl, long-chain acyl-CoA dehydrogenase; Ccl2, MCP-1; Ccl3, macrophage inflammatory protein-1α; Cd36, cluster of differentiation 36 fatty acid transporter; Cpt1a, carnitine palmitoyltransferase 1α; Cpt1b; carnitine palmitoyltransferase 1β; Emr1, F4/80, marker of macrophage infiltration; Il6, interleukin-6; Lpl, lipoprotein lipase; Ppara, peroxisome proliferator–activated receptor α; Ppargc1a, peroxisome proliferator–activated receptor γ coactivator 1α; Tnf, tumor necrosis factor-α. Figure 5. Gene expression levels in epididymal adipose tissue (A) and in gastrocnemius muscle (B). *P < 0.05, **P < 0.01. n = 4–13 per group. Acadm, medium-chain acyl-CoA dehydrogenase; Acadl, long-chain acyl-CoA dehydrogenase; Ccl2, MCP-1; Ccl3, macrophage inflammatory protein-1α; Cd36, cluster of differentiation 36 fatty acid transporter; Cpt1a, carnitine palmitoyltransferase 1α; Cpt1b; carnitine palmitoyltransferase 1β; Emr1, F4/80, marker of macrophage infiltration; Il6, interleukin-6; Lpl, lipoprotein lipase; Ppara, peroxisome proliferator–activated receptor α; Ppargc1a, peroxisome proliferator–activated receptor γ coactivator 1α; Tnf, tumor necrosis factor-α. More
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High-fat feeding preferentially promotes PPARγ target gene expression in Tx...
Published: 18 March 2010
FIG. 6. High-fat feeding preferentially promotes PPARγ target gene expression in Txnip-null WAT. A: mRNA transcript expression of PPARγ target genes and PPARγ2 in WAT before and after high-fat feeding. n = 8–12 mice per group for each transcript. AP2, fatty acid binding protein 4; PC, pyruvate carboxylase; PEPCK, phosphoenolpyruvate carboxykinase; ACC-α, acetyl-CoA carboxylase-α; FAS, fatty acid synthase; LPL, lipoprotein lipase. B: Transcript expression levels for non-PPARγ target genes PCG1α and UCP2 after HFD. C and D: Adiponectin, leptin, and GLUT transcript expression levels in WAT after SCD vs. HFD. n = 8–12 mice per group. FIG. 6. High-fat feeding preferentially promotes PPARγ target gene expression in Txnip-null WAT. A: mRNA transcript expression of PPARγ target genes and PPARγ2 in WAT before and after high-fat feeding. n = 8–12 mice per group for each transcript. AP2, fatty acid binding protein 4; PC, pyruvate carboxylase; PEPCK, phosphoenolpyruvate carboxykinase; ACC-α, acetyl-CoA carboxylase-α; FAS, fatty acid synthase; LPL, lipoprotein lipase. B: Transcript expression levels for non-PPARγ target genes PCG1α and UCP2 after HFD. C and D: Adiponectin, leptin, and GLUT transcript expression levels in WAT after SCD vs. HFD. n = 8–12 mice per group. More
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Interaction of fish oil and CLA in affecting mRNA levels of adipocyte-abund...
Published: 01 February 2005
FIG. 4. Interaction of fish oil and CLA in affecting mRNA levels of adipocyte-abundant genes in the liver. mRNA levels were analyzed by quantitative real-time PCR using specific primers and probes. mRNA abundances were calculated as the ratio of mRNA to the 18S rRNA level in each cDNA sample and expressed as percentages, assigning a value of 100 to the percentage in mice fed a CLA-free diet devoid of fish oil. Values represent means ± SE for 7–8 mice. □, mice fed CLA-free diets; ▪, mice fed CLA-containing diets. *P < 0.05, **P < 0.01 vs. mice fed a CLA-free diet containing 0% fish oil; #P < 0.05, ##P < 0.01 vs. mice fed a CLA diet containing 0% fish oil. FAT/CD36, fatty acid translocase/CD36; LPL, lipoprotein lipase. FIG. 4. Interaction of fish oil and CLA in affecting mRNA levels of adipocyte-abundant genes in the liver. mRNA levels were analyzed by quantitative real-time PCR using specific primers and probes. mRNA abundances were calculated as the ratio of mRNA to the 18S rRNA level in each cDNA sample and expressed as percentages, assigning a value of 100 to the percentage in mice fed a CLA-free diet devoid of fish oil. Values represent means ± SE for 7–8 mice. □, mice fed CLA-free diets; ▪, mice fed CLA-containing diets. *P < 0.05, **P < 0.01 vs. mice fed a CLA-free diet containing 0% fish oil; #P < 0.05, ##P < 0.01 vs. mice fed a CLA diet containing 0% fish oil. FAT/CD36, fatty acid translocase/CD36; LPL, lipoprotein lipase. More
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Interaction of fish oil and CLA in affecting mRNA levels in epididymal adip...
Published: 01 February 2005
FIG. 3. Interaction of fish oil and CLA in affecting mRNA levels in epididymal adipose tissue. mRNA levels were analyzed by quantitative real-time PCR using specific primers and probes. mRNA abundances were calculated as the ratio of mRNA to the 18S rRNA level in each cDNA sample and expressed as percentages, assigning a value of 100 to the percentage in mice fed a CLA-free diet devoid of fish oil. Values represent means ± SE for 7–8 mice. □, mice fed CLA-free dies; ▪, mice fed CLA-containing dies. *P < 0.05, **P < 0.01 vs. mice fed a CLA-free diet containing 0% fish oil; #P < 0.05, ##P < 0.01 vs. mice fed a CLA diet containing 0% fish oil. ALBP, adipocyte lipid-binding protein; FAT/CD36, fatty acid translocase/CD36; LPL, lipoprotein lipase. FIG. 3. Interaction of fish oil and CLA in affecting mRNA levels in epididymal adipose tissue. mRNA levels were analyzed by quantitative real-time PCR using specific primers and probes. mRNA abundances were calculated as the ratio of mRNA to the 18S rRNA level in each cDNA sample and expressed as percentages, assigning a value of 100 to the percentage in mice fed a CLA-free diet devoid of fish oil. Values represent means ± SE for 7–8 mice. □, mice fed CLA-free dies; ▪, mice fed CLA-containing dies. *P < 0.05, **P < 0.01 vs. mice fed a CLA-free diet containing 0% fish oil; #P < 0.05, ##P < 0.01 vs. mice fed a CLA diet containing 0% fish oil. ALBP, adipocyte lipid-binding protein; FAT/CD36, fatty acid translocase/CD36; LPL, lipoprotein lipase. More
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Selected gene expression following saline or TNF-α infusion. <em>A–F</em>...
Published: 01 November 2002
FIG. 4. Selected gene expression following saline or TNF-α infusion. A–F: Gene expression in adipose tissue. G–L: Gene expression in the liver. The duration of TNF-α or saline treatment is indicated in each panel. Each bar represents an individual rat; saline-infused rats (n = 6) are shown on the left and TNF-α-infused animals (n = 6) are on the right. The expression levels are raw data (average difference, according to Affymetrix) obtained from Affymetrix GENECHIP output file after normalization as described in research design and methods. P values (comparison of saline- and TNF-α-treated groups) are shown on top of each panel. C3, complement component prepro-C3; FAS, fatty acid synthase; LPL, lipoprotein lipase; LFACS, long-chain fatty acyl CoA synthase; SREBP1, sterol regulatory element binding protein 1; D site binding, D site albumin promoter binding protein; Gly Synthase, glycogen synthase; α2-μGRP, α2-μ globulin-related protein. FIG. 4. Selected gene expression following saline or TNF-α infusion. A–F: Gene expression in adipose tissue. G–L: Gene expression in the liver. The duration of TNF-α or saline treatment is indicated in each panel. Each bar represents an individual rat; saline-infused rats (n = 6) are shown on the left and TNF-α-infused animals (n = 6) are on the right. The expression levels are raw data (average difference, according to Affymetrix) obtained from Affymetrix GENECHIP output file after normalization as described in research design and methods. P values (comparison of saline- and TNF-α-treated groups) are shown on top of each panel. C3, complement component prepro-C3; FAS, fatty acid synthase; LPL, lipoprotein lipase; LFACS, long-chain fatty acyl CoA synthase; SREBP1, sterol regulatory element binding protein 1; D site binding, D site albumin promoter binding protein; Gly Synthase, glycogen synthase; α2-μGRP, α2-μ globulin-related protein. More
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Resistance to obesity in Wnt10b-<em>A</em><sup><em>y</em></sup>...
Published: 01 February 2007
FIG. 4. Resistance to obesity in Wnt10b-Ay mice at 1 year of age. Female wild-type–Ay and Wnt10b-Ay mice at 12 months of age were random fed or fasted overnight (n = 4). A: Body and adipose depot weights. d-wat, dorsolumbar white adipose tissue; O-WAT, ovarian white adipose tissue; P-WAT, perirenal white adipose tissue. B: Adipocyte area analysis and representative pictures of microscopic fields. C: Primary adipocytes were isolated from ovarian adipose tissue from wild-type–Ay and Wnt10b-Ay mice (n = 8). Gene expression was evaluated by quantitative RT-PCR for the indicated genes. Wnt10b-Ay is shown relative to wild type–Ay (means ± SE). C/EBP, CCAAT/enhancer-binding protein; FABP, fatty acid–binding protein 4; FAS, fatty acid synthase; FSP, fat-specific protein; LPL, lipoprotein lipase; PPAR, peroxisome proliferator–activated receptor. D: Blood glucose and serum proteins from random-fed (n = 4) and fasted (n = 4) mice. E: Quantitative RT-PCR of mRNA from perirenal adipose tissue comparing wild-type–Ay (n = 8) and Wnt10b-Ay (n = 8) mice. Statistical significance was evaluated using Student’s t test. *P < 0.05; **P < 0.001. FIG. 4. Resistance to obesity in Wnt10b-Ay mice at 1 year of age. Female wild-type–Ay and Wnt10b-Ay mice at 12 months of age were random fed or fasted overnight (n = 4). A: Body and adipose depot weights. d-wat, dorsolumbar white adipose tissue; O-WAT, ovarian white adipose tissue; P-WAT, perirenal white adipose tissue. B: Adipocyte area analysis and representative pictures of microscopic fields. C: Primary adipocytes were isolated from ovarian adipose tissue from wild-type–Ay and Wnt10b-Ay mice (n = 8). Gene expression was evaluated by quantitative RT-PCR for the indicated genes. Wnt10b-Ay is shown relative to wild type–Ay (means ± SE). C/EBP, CCAAT/enhancer-binding protein; FABP, fatty acid–binding protein 4; FAS, fatty acid synthase; FSP, fat-specific protein; LPL, lipoprotein lipase; PPAR, peroxisome proliferator–activated receptor. D: Blood glucose and serum proteins from random-fed (n = 4) and fasted (n = 4) mice. E: Quantitative RT-PCR of mRNA from perirenal adipose tissue comparing wild-type–Ay (n = 8) and Wnt10b-Ay (n = 8) mice. Statistical significance was evaluated using Student’s t test. *P < 0.05; **P < 0.001. More
Journal Articles
Journal: Diabetes
Diabetes 1988;37(5):610–615
Published: 01 May 1988
... subjects were distributed between hepatic triglyceride lipase (HTGL, mean ± SE 60.6 ± 4.6%) and extrahepatic lipoprotein lipase (LPL, 39.4 ± 4.6%). Confirmation of the identities of HTGL and LPL was provided by inhibitory antisera. Preheparin LPL activity was absent in plasma from a patient with type I...
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Lipid uptake. Relative mRNA expression of <span class="search-highlight">lipoprotein</span> <span class="search-highlight">lipase</span> (<span class="search-highlight">LPL</span>) (
Published: 13 December 2012
FIG. 2. Lipid uptake. Relative mRNA expression of lipoprotein lipase (LPL) (A) and cluster of differentiation 36 (CD36) (B) in MPGC-1α TG mice and control littermates. All values are expressed as mean ± SE (n = 8 per group). @Effect of genotype (wild-type [wt] vs. MPGC-1α TG). #Effect of training (sedentary [sed] vs. exercised [ex]). xGenotype times training interaction as assessed by ANOVA. Comparison between two individual groups: *Effects of training (sed vs. ex) and §Genotype (wt vs. MPGC-1α TG mice) were assessed by t test. One symbol indicates P < 0.05, two symbols indicate P < 0.01, and three symbols indicate P < 0.001. FIG. 2. Lipid uptake. Relative mRNA expression of lipoprotein lipase (LPL) (A) and cluster of differentiation 36 (CD36) (B) in MPGC-1α TG mice and control littermates. All values are expressed as mean ± SE (n = 8 per group). @Effect of genotype (wild-type [wt] vs. MPGC-1α TG). #Effect of training (sedentary [sed] vs. exercised [ex]). xGenotype times training interaction as assessed by ANOVA. Comparison between two individual groups: *Effects of training (sed vs. ex) and §Genotype (wt vs. MPGC-1α TG mice) were assessed by t test. One symbol indicates P < 0.05, two symbols indicate P < 0.01, and three symbols indicate P < 0.001. More
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Postheparin <span class="search-highlight">lipoprotein</span> <span class="search-highlight">lipase</span> (PH-<span class="search-highlight">LPL</span>) activity according to the LIPC −541...
Published: 01 July 2005
FIG. 2. Postheparin lipoprotein lipase (PH-LPL) activity according to the LIPC −541C>T genotype in blacks (A) and whites (B). Pretraining (□) and post-training (▪) columns represent the data adjusted for age, sex, and BMI. Error bars represent SE. P values are for the genotype differences. FIG. 2. Postheparin lipoprotein lipase (PH-LPL) activity according to the LIPC −541C>T genotype in blacks (A) and whites (B). Pretraining (□) and post-training (▪) columns represent the data adjusted for age, sex, and BMI. Error bars represent SE. P values are for the genotype differences. More
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Lipid storage is enhanced in <em>Mfap2</em><sup>−/−</sup> WAT. <ita
Published: 15 May 2014
Figure 3 Lipid storage is enhanced in Mfap2−/− WAT. A: Total adipocyte number in epididymal WAT (mean [±SEM] number of adipocytes per milligram of tissue multiplied by total fat pad mass; n = 5). B: White adipocyte size distribution was determined using a Beckman Multisizer, and lines represent the average of all samples (left). The distribution curves were used to determine the average volume of small and large adipocytes (right) (mean ± SEM; n = 10 and 8). C: A pictomicrograph of epididymal WAT from 5-month-old WT and Mfap2−/− mice (scale bar 100 μm; image color was inverted to accentuate adipocyte cell borders). D and F: FA uptake, not lipolysis, is enhanced in Mfap2−/− WAT. Assays were performed on intact WAT explants. D: FA uptake, determined by the uptake of tritiated oleic acid, in the presence/absence of 10 μmol/L insulin (mean ± SEM; n = 5–6). F: Lipolysis, determined by glycerol release following the addition of 10 μmol/L isoproterenol (mean ± SEM; n = 4–5). E and G: Differential expression of lipid metabolism–associated genes in Mfap2−/− muscle tissue. qPCR was performed on RNA extracted from the muscle of WT and Mfap2−/− mice fed control chow or HFD (mean ± SEM; n = 5 and 6). Gene targets included the following: Lpl (lipoprotein lipase), Cd36 (FA translocase), Plin5 (perilipin 5), Plin2 (perilipin 2, adipose differentiation-related protein [ADFP]), Dgat2 (diacylglycerol acyltransferase 2), Cpt1b (carnitine palmitoyl transferase 1b), Pparα, Pparδ, Ppargc1α (PGC-1α, PPARγ coactivator 1 α), and Ucp-3. The Student t test was used for single comparisons (*P ≤ 0.05). Lg, large; Sm, small; vol, volume. Figure 3. Lipid storage is enhanced in Mfap2−/− WAT. A: Total adipocyte number in epididymal WAT (mean [±SEM] number of adipocytes per milligram of tissue multiplied by total fat pad mass; n = 5). B: White adipocyte size distribution was determined using a Beckman Multisizer, and lines represent the average of all samples (left). The distribution curves were used to determine the average volume of small and large adipocytes (right) (mean ± SEM; n = 10 and 8). C: A pictomicrograph of epididymal WAT from 5-month-old WT and Mfap2−/− mice (scale bar 100 μm; image color was inverted to accentuate adipocyte cell borders). D and F: FA uptake, not lipolysis, is enhanced in Mfap2−/− WAT. Assays were performed on intact WAT explants. D: FA uptake, determined by the uptake of tritiated oleic acid, in the presence/absence of 10 μmol/L insulin (mean ± SEM; n = 5–6). F: Lipolysis, determined by glycerol release following the addition of 10 μmol/L isoproterenol (mean ± SEM; n = 4–5). E and G: Differential expression of lipid metabolism–associated genes in Mfap2−/− muscle tissue. qPCR was performed on RNA extracted from the muscle of WT and Mfap2−/− mice fed control chow or HFD (mean ± SEM; n = 5 and 6). Gene targets included the following: Lpl (lipoprotein lipase), Cd36 (FA translocase), Plin5 (perilipin 5), Plin2 (perilipin 2, adipose differentiation-related protein [ADFP]), Dgat2 (diacylglycerol acyltransferase 2), Cpt1b (carnitine palmitoyl transferase 1b), Pparα, Pparδ, Ppargc1α (PGC-1α, PPARγ coactivator 1 α), and Ucp-3. The Student t test was used for single comparisons (*P ≤ 0.05). Lg, large; Sm, small; vol, volume. More
Journal Articles
Journal: Diabetes
Diabetes 1987;36(11):1238–1245
Published: 01 November 1987
...Philip A Kern; Angela Mandic; Robert H Eckel Human adipose tissue lipoprotein lipase (LPL) is stimulated in vivo by an insulin-glucose infusion. However, previous work by us showed no effect of physiologic insulin concentrations on LPL in isolated human adipocytes. To pursue further the regulation...
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Ectopic expression of two adipocyte-induced miRNAs, miR-103 or miR-143, acc...
Published: 02 February 2009
FIG. 6. Ectopic expression of two adipocyte-induced miRNAs, miR-103 or miR-143, accelerates adipogenesis. A: miR-103 and miR-143 are induced during 3T3-L1 adipogenesis. miRNA expression levels are measured by RT-PCR, normalized to internal control and plotted relative to their respective levels in preadipocyte (day 0). Data are expressed as mean ± SE (n = 3). B: Expression level of miR-103 or miR-143 in infected and sorted cells compared with vector control. Data are expressed as mean ± SE (n = 3). C: Ectopic expression of miR-103 or miR-143 has little effect on 3T3-L1 cell growth by MTT assay. Data are expressed as mean ± SE (n = 6). D: Ectopic expression of miR-103 or miR-143 increases triglyceride accumulation at day 4 (D4) but not day 7 (D7). Triglycerides are normalized to total protein and plotted relative to the level of the control cells expressing vector alone at D7. Data are expressed as mean ± SE (n = 6). **P < 0.01, *P < 0.05. E: Ectopic expression of miR-103 or miR-143 hastens expression of adipogenic markers at an early stage (days 2 and 4) of adipogenesis. mRNA levels are measured by RT-PCR, normalized to internal control and plotted relative to their respective levels at day 2 (D2). Data are expressed as mean only (n = 3). PPARG2, peroxisome proliferator-activated receptor γ 2; G0s2, G0/G1 switch 2; FABP4, fatty acid binding protein 4; GLUT4, glucose transporter 4; LPL, lipoprotein lipase. F: Ectopic expression of miR-103 or miR-143 hastens expression of adipogenic markers at day 2 (D2). Data are expressed as mean ± SE (n = 4). ***P < 0.001, **P < 0.01, *P < 0.05 by one-sample Student's t test. FIG. 6. Ectopic expression of two adipocyte-induced miRNAs, miR-103 or miR-143, accelerates adipogenesis. A: miR-103 and miR-143 are induced during 3T3-L1 adipogenesis. miRNA expression levels are measured by RT-PCR, normalized to internal control and plotted relative to their respective levels in preadipocyte (day 0). Data are expressed as mean ± SE (n = 3). B: Expression level of miR-103 or miR-143 in infected and sorted cells compared with vector control. Data are expressed as mean ± SE (n = 3). C: Ectopic expression of miR-103 or miR-143 has little effect on 3T3-L1 cell growth by MTT assay. Data are expressed as mean ± SE (n = 6). D: Ectopic expression of miR-103 or miR-143 increases triglyceride accumulation at day 4 (D4) but not day 7 (D7). Triglycerides are normalized to total protein and plotted relative to the level of the control cells expressing vector alone at D7. Data are expressed as mean ± SE (n = 6). **P < 0.01, *P < 0.05. E: Ectopic expression of miR-103 or miR-143 hastens expression of adipogenic markers at an early stage (days 2 and 4) of adipogenesis. mRNA levels are measured by RT-PCR, normalized to internal control and plotted relative to their respective levels at day 2 (D2). Data are expressed as mean only (n = 3). PPARG2, peroxisome proliferator-activated receptor γ 2; G0s2, G0/G1 switch 2; FABP4, fatty acid binding protein 4; GLUT4, glucose transporter 4; LPL, lipoprotein lipase. F: Ectopic expression of miR-103 or miR-143 hastens expression of adipogenic markers at day 2 (D2). Data are expressed as mean ± SE (n = 4). ***P < 0.001, **P < 0.01, *P < 0.05 by one-sample Student's t test. More
Journal Articles
Journal: Diabetes
Diabetes 1997;46(8):1346–1353
Published: 01 August 1997
...Brian Rodrigues; Margaret C Cam; Kong Jian; Fiona Lim; Nandakumar Sambandam; Greg Shepherd Lipoprotein lipase (LPL) is an endothelial-bound enzyme that is rate determining for the clearance of triacylglycerol-rich lipoproteins. Previous studies using rats with streptozotocin (STZ)-induced diabetes...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(3):867–870
Published: 01 March 2002
...Jochen Schneider; Joerg Kreuzer; Andreas Hamann; Peter P. Nawroth; Klaus A. Dugi Lipoprotein lipase (LPL) plays a key role in lipid metabolism by hydrolyzing triglycerides in circulating lipoproteins. Low LPL activity has been linked to coronary artery disease (CAD), but the factors influencing LPL...
Journal Articles
Journal: Diabetes
Diabetes 1998;47(1):113–118
Published: 01 January 1998
... of the apolipoprotein (apo) B-containing lipoproteins (VLDL, LDL) with cholesteryl ester (CE). This disturbance is closely linked to iatrogenic hyperinsulinemia and the nonphysiologic stimulation of lipoprotein lipase (LpL), a physiologic activator of CET, because lowering systemic insulin levels by administering...