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nac-n-acetylcysteine

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Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(5):1131–1137
Published: 01 May 1999
... into the culture medium of BRECs treated with VEGF for 24 h was increased by 2.2-fold compared with the control. Inhibitors of transcription factor NF-kappaB, N-alpha-tosyl-L-lysine chloromethylketone (TLCK) and N-acetylcysteine (NAC), as well as an inhibitor of the extracellular signal-regulated kinase (ERK...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(2):480–486
Published: 01 February 2006
... hyperglycemia with or without N-acetylcysteine (NAC) infusion, and one during mannitol infusion. Glycocalyx measurements were reproducible (1.7 ± 0.2 vs. 1.7 ± 0.3 l). Hyperglycemia reduced glycocalyx volume (to 0.8 ± 0.2 l; P < 0.05), and NAC was able to prevent the reduction (1.4 ± 0.2 l...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(7):2287–2293
Published: 01 July 2002
... production, and lowers cAMP levels in U937 cells. However, BHB did not have any effect on TNF-α secretion or oxygen radicals production in U937 cells. Third, exogenous addition of dibutyryl cAMP, endogenous stimulation of cAMP production by forskolin, and antioxidant N-acetylcysteine (NAC) prevented...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(5):1222–1228
Published: 01 May 2003
... of diabetic rats compared to control embryos. Supplementing the high-glucose culture with the antioxidant N-acetylcysteine (NAC) increased GAPDH activity and diminished embryonic dysmorphogenesis. Embryos cultured with iodoacetate showed both decreased GAPDH activity and dysmorphogenesis...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(4):813–820
Published: 01 April 1999
... hyperglycemia in vitro and maternal diabetes in vivo caused embryonic dysmorphogenesis and increased embryonic levels of 8-epi-PGF2alpha, an indicator of lipid peroxidation. Addition of N-acetylcysteine (NAC) to the culture medium normalized the morphology and 8-epi-PGF2alpha concentration of the embryos...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(9):1850–1855
Published: 01 September 1999
.... The antioxidants vitamin E and N-acetylcysteine (NAC) blocked increase in lipid peroxidation in AA-treated RBCs. To examine the effects of ketone bodies in vivo, studies were performed that showed a significant decrease in GSH and an increase in lipid peroxidation levels in RBCs of hyperketonemic diabetic patients...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(11):2722–2731
Published: 01 November 2007
... mmol/l hyperglycemia with/without co-infusion of one of the following antioxidants: taurine (2-amino ethanesulfonic acid) (TAU), an aldehyde scavenger; N-acetylcysteine (NAC), a precursor of glutathione; or tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) (TPO), a superoxide...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(4):677–684
Published: 01 April 1998
... superoxide dismutase (SOD) and N-acetylcysteine (NAC) were each able to diminish the dysmorphogenesis induced by the COX inhibitors, at doses previously shown to diminish glucose-induced embryonic damage in the same in vitro culture system. In conclusion, the present study shows that a high glucose...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(8):2121–2128
Published: 01 August 2003
...) antibody, protein kinase C (PKC) inhibitors, calphostin C, and GF109203X, or the antioxidant N-acetylcysteine (NAC) blocked the effects of leptin. Similar results were observed in leptin-treated J774 macrophages. In these cells, leptin increased the membrane expression of conventional PKC isoforms...
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):18-LB
Published: 01 June 2020
... activate PERK. Therefore, we determined if the administration of tris-(hydroxymethyl)-aminomethane (THAM; an alkalizing agent) and N-acetylcysteine (NAC; an antioxidant) decrease RH-induced post-ischemic PERK activation in ITD + RH rats. Wistar rats were treated with insulin 2-3 weeks after streptozotocin...
Journal Articles
Journal: Diabetes
Diabetes 2020;69(8):1650–1661
Published: 22 May 2020
... of this study was to determine whether N-acetylcysteine (NAC), an anti-inflammatory antioxidant, attenuates programmed susceptibility to obesity and insulin resistance in offspring of mothers on a high-fat diet (HFD) during pregnancy. CD1 female mice were acutely fed a standard breeding chow or HFD. NAC...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1813-P
Published: 01 July 2018
..., high (HGI >70) GI diet plus the anti-oxidant N-acetylcysteine (HGI/NAC) 600 mg BID or HGI diet plus placebo (HGI/PLAC). Subjects underwent CGMS (iPro), fasting markers of oxidative stress (GSH/GSSG and TBARS) and an IVGTT at the end of each diet. Independent t-test was used to test the intervention...
Images
<em>A</em>: Effect of increasing concentrations of <em><span class="search-highlight">N</span></em>
Published: 01 March 2003
FIG. 1. A: Effect of increasing concentrations of N-acetylcysteine (NAC) on the disappearance of PDX-1 measured by Western blot analysis using nuclear extracts of HIT-T15 cells cultured in RPMI media containing either 0.8 or 11.1 mmol/l glucose for passage 74 (p74; control) and passages 123–126 (p123-126). N-acetylcysteine prevented the disappearance of PDX-1 protein that was associated with prolonged culturing with the higher glucose concentration. B: Effect of increasing concentrations of N-acetylcysteine on DNA binding of PDX-1 measured by electromobility shift assay of nuclear extracts in the same passages of HIT-T15 cells as described in A. N-acetylcysteine prevented the disappearance of PDX-1 binding that was associated with prolonged culturing with the higher glucose concentration. The methods are the same as in Tanaka et al. ( 12 ). FIG. 1. A: Effect of increasing concentrations of N-acetylcysteine (NAC) on the disappearance of PDX-1 measured by Western blot analysis using nuclear extracts of HIT-T15 cells cultured in RPMI media containing either 0.8 or 11.1 mmol/l glucose for passage 74 (p74; control) and passages 123–126 (p123-126). N-acetylcysteine prevented the disappearance of PDX-1 protein that was associated with prolonged culturing with the higher glucose concentration. B: Effect of increasing concentrations of N-acetylcysteine on DNA binding of PDX-1 measured by electromobility shift assay of nuclear extracts in the same passages of HIT-T15 cells as described in A. N-acetylcysteine prevented the disappearance of PDX-1 binding that was associated with prolonged culturing with the higher glucose concentration. The methods are the same as in Tanaka et al. (12). More
Journal Articles
Journal: Diabetes
Diabetes 2018;67(1):120–130
Published: 27 October 2017
...Chunxue Zhou; Vanessa H. Routh We previously showed that the glutathione precursor, N-acetylcysteine (NAC), prevented hypoglycemia-associated autonomic failure (HAAF) and impaired activation of ventromedial hypothalamus (VMH) glucose-inhibited (GI) neurons by low glucose after recurrent...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2015;64(4):1431–1443
Published: 24 November 2014
...), and retinaldehyde dehydrogenase (Aldh1a2) was decreased and E-cadherin expression was increased in the hearts of fetuses of diabetic mothers. Of note, these abnormalities were all rescued by treatment with N-acetylcysteine (NAC) in diabetic females during gestation. Ex vivo analysis showed...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2007;56(4):1136–1142
Published: 01 April 2007
.../Invitrogen. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP), N-acetylcysteine (NAC), ebselen, palmitate, and laminin were from Sigma. All compounds were prepared as stock solutions in appropriate solvents. On the day of the experiment, stock solutions were diluted to the desired final...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(12):2927–2937
Published: 01 December 2007
... (P < 0.01), an effect prevented by coinfusion of the antioxidants N-acetylcysteine (NAC) and taurine. Similar to the findings in vivo, 48-h infusion of oleate decreased glucose-stimulated insulin secretion ex vivo (P < 0.01) and induced oxidative stress (P < 0.001...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2141-P
Published: 01 June 2019
... glucose treatment profoundly increased Ser-40 phosphorylation and translocation of Nrf2, while the same effect by CDDO-Me treatment took 50 minutes in INS1 cells. The glucose-mediated activation and translocation of Nrf2 was blocked by the antioxidant N-acetylcysteine (NAC), which also attenuated glucose...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_1):S119–S124
Published: 01 February 2004
...-mail: rpr@u.washington.edu 27 3 2003 4 3 2003 DIABETES 2004 GSH, glutathione NAC, n-acetylcysteine ROS, reactive oxygen species Type 2 diabetes is generally viewed as a clinical syndrome with variable phenotypic expression rather than a single disease...
Images
<em>A</em>: Marked attenuation of the development of hyperglycemia ...
Published: 01 March 2003
FIG. 2. A: Marked attenuation of the development of hyperglycemia in ZDF rats treated daily with N-acetylcysteine (NAC). Controls were ZDF animals treated with N-acetylcysteine vehicle and Zucker Lean Control (ZLC) rats, which do not spontaneously develop diabetes. B: Effect of GPx (AdGPx) adenoviral overexpression in isolated Wister rat islets. a: Adenoviral GPx overexpression in islets caused a sixfold increase in islet GPx activity. b: Adenoviral GPx prevented the decrease in islet insulin mRNA levels caused by exposure to ribose, a sugar that generates ROS in islets. c: Adenoviral GPx prevented the decrease in islet insulin content caused by exposure to ribose. d: Adenoviral GPx prevented the decrease in glucose-induced insulin secretion caused by exposure to ribose. Taken from Tanaka et al. ( 12 , 23 ): *P < 0.05–0.001. FIG. 2. A: Marked attenuation of the development of hyperglycemia in ZDF rats treated daily with N-acetylcysteine (NAC). Controls were ZDF animals treated with N-acetylcysteine vehicle and Zucker Lean Control (ZLC) rats, which do not spontaneously develop diabetes. B: Effect of GPx (AdGPx) adenoviral overexpression in isolated Wister rat islets. a: Adenoviral GPx overexpression in islets caused a sixfold increase in islet GPx activity. b: Adenoviral GPx prevented the decrease in islet insulin mRNA levels caused by exposure to ribose, a sugar that generates ROS in islets. c: Adenoviral GPx prevented the decrease in islet insulin content caused by exposure to ribose. d: Adenoviral GPx prevented the decrease in glucose-induced insulin secretion caused by exposure to ribose. Taken from Tanaka et al. (12,23): *P < 0.05–0.001. More