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nk-κb-nuclear-factor-κb

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Journal Articles
Journal: Diabetes
Diabetes 2007;56(8):1986–1998
Published: 01 August 2007
... IR, insulin receptor IRS-1, insulin receptor substrate-1 JNK, c-Jun NH2-terminal kinase LPS, lipopolysaccharide NK-κB, nuclear factor-κB RER, respiratory exchange ratio TNF, tumor necrosis factor TLR, Toll-like receptor WAT, white adipose tissue Insulin resistance in obesity...
Journal Articles
Journal: Diabetes
Diabetes 2017;66(10):2681–2690
Published: 02 May 2017
... found that the protein expressions of BK-β1 and Nrf2 were markedly downregulated, whereas those of the nuclear factor-κB (NF-κB) and the muscle ring finger protein 1 (MuRF1 [a ubiquitin E3 ligase for BK-β1]) were significantly upregulated in HFD mouse arteries. Adenoviral expression of Nrf2 suppressed...
Journal Articles
Journal: Diabetes
Diabetes 2016;65(8):2367–2379
Published: 23 May 2016
...Parameswaran Ramakrishnan; Mary A. Yui; Jeffrey A. Tomalka; Devdoot Majumdar; Reshmi Parameswaran; David Baltimore The nuclear factor-κB protein c-Rel plays a critical role in controlling autoimmunity. c-Rel–deficient mice are resistant to streptozotocin-induced diabetes, a drug-induced model...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2003;52(2):348–355
Published: 01 February 2003
... between -2,180 bp and −2,478 bp. Mutation of either of the two nuclear factor (NF)-κB sites present in this region abrogated IL-1β-induced MCP-1 promoter activity. Binding of NF-κB to the two sites was shown in vitro by gel shift assays, while supershift assays revealed the presence of p65/p50...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(10):2219–2224
Published: 01 October 2001
...Harry Heimberg; Yves Heremans; Christian Jobin; Ruth Leemans; Alessandra K. Cardozo; Martine Darville; Décio L. Eizirik Cytokine-induced β-cell death is an important event in the pathogenesis of type 1 diabetes. The transcription factor nuclear factor-κB (NF-κB) is activated by interleukin-1β (IL...
Journal Articles
Journal: Diabetes
Diabetes 2014;63(3):960–975
Published: 13 February 2014
... aspects of human pathophysiology. Inhibitor of κB kinase (IKK)/nuclear factor-κB (NF-κB) signaling is a master regulator of inflammation; however, its role in diabetes pathogenesis is controversially discussed by studies using different inhibition approaches. To investigate the potential diabetogenic...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2005;54(7):2227–2234
Published: 01 July 2005
... oxygen species (ROS). These effects were abolished by vitamin E. Inhibition of NAD(P)H oxidase and protein kinase C (PKC) suppressed the effect of leptin on ROS production. In HASMCs, leptin induced PKC, extracellular signal–regulated kinase (ERK)1/2, and nuclear factor-κB (NF-κB) activation...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(5):909–920
Published: 01 May 2001
...′ (547 bp); Janus protein tyrosine kinase-2 (JAK-2) F 5′-CTGCAGGACAACACTGGAGA-3′, R 5′-GGGACTTTCACCTGGTTCCT-3′ (441 bp); nuclear factor (NF)-κB-p105 F 5′-TCATCCACCTTCATGCTCAG-3′, R 5′-GCCAACGAGATGTTGTCGTA-3′ (447 bp); C/EBPδ F 5′-GAGACTCCGAACGACCGATA-3′, R 5′-GTCAGAGCTGGTGCCTCTTT-3′ (310 bp...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(4):1286–1294
Published: 22 March 2011
... environment leads to insulin signaling defects in EPCs and thereby reduces their survival. Modifying EPCs by a knockdown of nuclear factor-κB (NF-κB) can reverse the insulin signaling defects, improve EPC survival, and decrease neointimal hyperplasia in Zucker fatty rats postangioplasty. RESEARCH DESIGN...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2007;56(3):574–582
Published: 01 March 2007
... < 0.05), nuclear factor-κB (NF-κB) p65 expression (P < 0.01), NF-κB DNA binding (P < 0.01), and NF-κB p65, p50, c-Rel, p52, and RelB transcriptional activity (P < 0.01). To define whether these observations were direct effects of the nutrient intervention...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(9):2491–2501
Published: 01 September 2006
... regulated antiapoptotic gene expressed in cytokine-stimulated human and mouse islets. Cytokine induction of A20 mRNA in primary islets and insulinoma cells was rapid and observed within 1 h, consistent with A20 being an immediate early response gene in β-cells. Regulation of A20 was nuclear factor-κB (NF-κB...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(suppl_2):S97–S107
Published: 01 December 2005
... leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, respectively, share the activation of a final common pathway involving interleukin (IL)-1β, nuclear factor (NF)-κB, and Fas. We review herein the similarities and differences between the mechanisms of β-cell death...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(8):2245–2255
Published: 01 August 2006
... labeling (TUNEL)-positive cells were significantly higher. This alteration in PCNA- and TUNEL-positive cells in diabetes was not observed in RAGE−/− mice. Similarly, the percentage of nuclear factor κB–activated cells is enhanced in diabetes, with the regulation dependent on the presence of RAGE...
Journal Articles
Journal: Diabetes
Diabetes 2015;64(10):3600–3613
Published: 26 June 2015
..., and inflammatory markers, and increased collagen and smooth muscle cell content. Mechanistically, the renoprotective and antiatherosclerotic effects of DMAG are mediated by the induction of protective HSP70 along with inactivation of nuclear factor-κB (NF-κB) and signal transducers and activators of transcription...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2003;52(5):1256–1264
Published: 01 May 2003
... blood monocytes leads to increased expression of the inflammatory cytokine, tumor necrosis factor-α (TNF-α), in an oxidant stress, nuclear factor (NF)-κB, and AP-1 transcription factor-dependent manner ( 16 ). HG culture also increased basal and TNF-α−induced p38 mitogen-activated protein kinase (MAPK...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(8):2396–2403
Published: 01 August 2005
... regulatory factor JAK, janus kinase MIP, macrophage inflammatory protein MLDS, multiple low-dose streptozotocin NF-κB, nuclear factor-κB SOCS, suppressor of cytokine signaling STAT, signal transducer and activator of transcription The main focus in studies on the pathogenesis of autoimmune type 1...
Journal Articles
Journal: Diabetes
Diabetes 2017;66(9):2459–2471
Published: 29 June 2017
... phase of wound repair. In diabetes, macrophages display a prolonged inflammatory phenotype in late wound healing. Mixed-lineage leukemia-1 (MLL1) has been shown to direct gene expression by regulating nuclear factor-κB (NF-κB)–mediated inflammatory gene transcription. Thus, we hypothesized that MLL1...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2012;61(7):1664–1666
Published: 15 June 2012
... is tilted toward the prodiabetogenic process. HOT could push the balance either toward the prodiabetogenic pathway or toward the antidiabetogenic pathway. The outcome may be determined by multiple factors. NFκB, nuclear factor κB; RORγT, retinoid-related orphan receptor γ T; HO-1, hemeoxygenase 1. FIG. 1...
Journal Articles
Journal: Diabetes
Diabetes 2013;62(6):1932–1944
Published: 20 May 2013
... end products (AGEs) and receptor for AGE (RAGE) expression were present in pancreatic islets of obese LGALS3−/− animals accompanied with elevated phosphorylated nuclear factor-κB (NF-κB) p65 and mature caspase-1 protein expression in pancreatic tissue and VAT. In vitro stimulation...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(3):743–751
Published: 01 March 2004
... ( Table 2 ). AGE, advanced glycation end product Ctrl BSA, BSA incubated in the absence of modifying agent EC, endothelial cell HC, hydrocortisone HMEC, human microvascular EC hsRAGE, human soluble RAGE ICAM-1, intercellular adhesion molecule-1 IκBα, inhibitor of nuclear factor-κB IL...