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Search Results for pg-prostaglandin
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Masaaki Suzuki, Motoyoshi Ikebuchi, Kazuya Shinozaki, Yasushi Hara, Motoo Tsushima, Tatsuo Matsuyama, Yutaka Harano
Published: 01 July 1996
... Ca2+ decreased significantly, but 6-ke-to-prostaglandin (PG) F1α and PGE2 did not change. Insulin resistance decreased by using antihypertensive treatments with bunazosin, cilazapril, amlodipine, and benidipine in hypertensive subjects. Diagnostic criteria for the insulin...
Published: 01 September 1998
...R P Robertson Dramatic, scientifically important discoveries in prostaglandin (PG) pharmacology and physiology have taken place over the past decade. Chief among these discoveries is the identification of two separate forms of cyclooxygenase (COX), a constitutive and an inducible form, both...
Published: 01 April 1998
... was used in which day-9 embryos were exposed to high concentrations of glucose, arachidonic acid, prostaglandin (PG)E2, COX inhibitors, and antioxidants for 48 h. Increased glucose concentration (from 10 to 30 mmol/l) caused embryonic dysmorphogenesis, and addition of either 60 pmol/l arachidonic acid...
Angelo Avogaro, Cristina Crepaldi, Francesco Piarulli, Daniele Milan, Anna Valerio, Paola Pavan, David Sacerdoti, Alessio Calabrò, Ian Macdonald, Gaetano Crepaldi, Roldano Scognamiglio, Antonio Tiengo
Published: 01 May 1996
... are the results not only of profound volume depletion but also of the effects of increased production of vasodilating prostaglandins (PGs), principally PGI2, released by adipose tissue. In animal and in vitro models, prostaglandin synthesis is increased during insulin deficiency. We assessed...
Published: 01 May 2005
...Heiko Kämpfer; Ronald Schmidt; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank This study focused on the regulation of prostaglandin (PG) production in diabetes-impaired wound tissue. Cyclooxygenase (COX)- 1 and -2 expression and activity were severely dysregulated in chronic wounds...
Published: 01 April 1999
...P Wentzel; N Welsh; U J Eriksson Previous experimental studies suggest that diabetic embryopathy is associated with an excess of radical oxygen species (ROS), as well as with a disturbance of prostaglandin (PG) metabolism. We aimed to investigate the relationship between these pathways and used...
Published: 01 March 1995
... of transforming growth factor β (TGF-β) in the mediation of the action of the stable TXA2/prostaglandin (PG) endoperoxide analog U-46619 to stimulate fibronectin (Fn) synthesis in cultured rat MC. Exogenous TGF-β increased Fn synthesis by MC in a concentration- and time-dependent fashion, as reflected...
Published: 01 January 2002
... or superoxide anion, suggesting that ONOO− was responsible. Furthermore, SQ29548, a thromboxane/prostaglandin (PG) H2 (TP) receptor antagonist, significantly reduced the increased endothelial cell apoptosis and the expression of soluble intercellular adhesion molecule-1 that occurred...
Shinsuke Kiritoshi, Takeshi Nishikawa, Kazuhiro Sonoda, Daisuke Kukidome, Takahumi Senokuchi, Tomoko Matsuo, Takeshi Matsumura, Hiroshi Tokunaga, Michael Brownlee, Eiichi Araki
Published: 01 October 2003
... in bovine endothelial cells. Because several studies have postulated a role for prostaglandins (PGs) in the glomerular hyperfiltration seen in early diabetes, we evaluated the effect of mitochondrial ROS on expression of the inducible isoform of cyclooxygenase (COX-2) in cultured human mesangial cells (HMCs...
in Endothelial Nitric Oxide Synthase–Dependent Tyrosine Nitration of Prostacyclin Synthase in Diabetes In Vivo > Diabetes
Published: 01 November 2006
FIG. 2. Effects of high glucose on the expression of COX and prostaglandin production in isolated BCAs. A: High glucose increases the detections of COX-2. Isolated BCAs were exposed to normal glucose (5 mmol/l, control), high glucose (30 mmol/l), or mannitol for 4 h as described in
research design and methods. The levels of COX-1 and -2 were detected in Western blots using the specific antibodies. The blot is a representative of three blots obtained from three independent experiments. B: High glucose increases PGE2 synthesis. Isolated BCAs were exposed to normal glucose (5 mmol/l, control), high glucose (30 mmol/l), or mannitol for 4 h. At the end of incubation, the media were collected and analyzed for PGs, as indicated in research design and methods. The results are expressed as means ± SD (n = 8; †P < 0.01, 5 vs. 30 mmol/l glucose). FIG. 2. Effects of high glucose on the expression of COX and prostaglandin production in isolated BCAs. A: High glucose increases the detections of COX-2. Isolated BCAs were exposed to normal glucose (5 mmol/l, control), high glucose (30 mmol/l), or mannitol for 4 h as described in research design and methods. The levels of COX-1 and -2 were detected in Western blots using the specific antibodies. The blot is a representative of three blots obtained from three independent experiments. B: High glucose increases PGE2 synthesis. Isolated BCAs were exposed to normal glucose (5 mmol/l, control), high glucose (30 mmol/l), or mannitol for 4 h. At the end of incubation, the media were collected and analyzed for PGs, as indicated in research design and methods. The results are expressed as means ± SD (n = 8; †P < 0.01, 5 vs. 30 mmol/l glucose). More
Published: 01 June 2019
... phenotype and that inhibition of iPLA2βreduces the development of T1D. We have now identified that iPLA2βactivation induces generation of select pro-inflammatory lipids in the non-obese diabetic (NOD) mice, including prostaglandins (PGs) and DHETs that accompany T1D development...
Published: 01 May 1983
...- Glucose production (Ra) and utilization (Rd) were de- BETES 32:439-444, May 1983. termined by isotope dilution using the nonrecycling la- bel 3-3H glucose. In controls, glucagon levels (IRG) rose from a basal of 44 ± 12 to 260 ± 40 pg/ml It has been demonstrated that prostaglandins signifi- (mean ± SEM...
Norberto Perico, Ariela Benigni, Maurizio Gabanelli, Antonella Piccinelli, Marek Ròg, Carlo De Riva, Giuseppe Remuzzi
Published: 01 April 1992
...Norberto Perico; Ariela Benigni; Maurizio Gabanelli; Antonella Piccinelli; Marek Ròg; Carlo De Riva; Giuseppe Remuzzi The relative contribution of atrial natriuretic peptide (ANP) and vasodilatory prostaglandins to hyperfiltration in Wistar rats with experimental diabetes was studied 6–8 wk after...
in Immunomodulation by Mesenchymal Stem Cells :
A Potential Therapeutic Strategy for Type 1 Diabetes
Published: 01 July 2008
FIG. 1. Schematic representation of plausible mechanisms by which MSCs regulate immune responses. MSCs might also reduce the generation and differentiation of dendritic cells ( 1 ). MSCs can increase the percentage of regulatory T-cells through production of cytokines imparting regulation or promo... More
Published: 01 July 2018
... of Treg cells and beige adipocytes in WAT and diet-induced obesity. Mechanistically, mTORC1 signaling phosphorylated CREB regulated transcription coactivator 2 (CRTC2) and subsequently suppressed expression of cyclooxygenase 2 (COX-2) and secretion of prostaglandins (PGs) including PGI2, PGD2 and PGE2...
Antje Vennemann, Anemone Gerstner, Niklas Kern, Nerea Ferreiros Bouzas, Shuh Narumiya, Takayuki Maruyama, Rolf M. Nüsing
Published: 15 June 2012
... of cyclooxygenase (prostaglandin synthase [PTGS]) enzymes and prostaglandin (PG) E2 signaling pathways in streptozotocin (STZ)-induced type 1 diabetes. Blood glucose, insulin, and survival rate were studied in mice with targeted disruption of the genes for PTGS and PGE receptors (PTGERs). PGE2...
Published: 01 May 1980
...Eric Topol; Robert G Brodows Prostaglandin (PG) E2 stimulates glucose-induced insulin release from isolated rat pancreatic islets but inhibits acute insulin release to intravenous (i.v.) glucose in man. Since PGs act as intracellular messengers, we have studied the effect of endogenous...
Published: 01 July 1983
... diabetic subjects and 27 age- and sex-matched nondiabetic subjects. It was found that the major prostanoid products formed were thromboxane B2 (TxB2) and prostaglandin E (PGE). Production of both these substances was greatly enhanced in PMNL from control and diabetic subjects...
Published: 01 August 1978
...Sumer Pek, MD; Tong-Yuan Tai, MD; Alan Elster, PhD The effects of prostaglandins (PG) E1, E2, and F2 upon the release of glucagon and insulin from the isolated perfused rat pancreas were investigated. In the presence of 5.6 mM glucose the release of both glucagon...
Published: 01 February 1985
...Richard P Day; Sally A Little; R Paul Robertson Prostaglandin (PG) E2 binding to fat cells and its consequent antilipolytic effect have been studied in experiments using laboratory animals, but no binding studies have yet been reported using adipocytes from humans. Consequently, we have...