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pgc-peroxisome-proliferator–activated-receptor-γ-coactivator

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Journal Articles
Journal: Diabetes
Diabetes 2012;61(5):1153–1159
Published: 13 April 2012
...Debin Lu; Ling Zhang; Haihui Wang; Yan Zhang; Jian Liu; Jing Xu; Ziwen Liang; Wuquan Deng; Youzhao Jiang; Qinan Wu; Shufa Li; Zhihua Ai; Yuxu Zhong; Ying Ying; Hongyan Liu; Feng Gao; Zhonghui Zhang; Bing Chen To examine whether the peroxisome proliferatoractivated receptor-γ coactivator-1α (PGC-1α...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(1):157–167
Published: 07 October 2010
...Ling Li; Ruping Pan; Rong Li; Bernd Niemann; Anne-Cathleen Aurich; Ying Chen; Susanne Rohrbach OBJECTIVE Transcriptional peroxisome proliferatoractivated receptor-γ coactivator-1α (PGC-1α) plays a key role in mitochondrial biogenesis and energy metabolism and is suggested to be involved...
Includes: Supplementary data
Images
Enhanced Nrf2 <span class="search-highlight">activity</span> induces earlier onset of IR in Lep<em><sup>ob/ob</sup></em>...
Published: 15 November 2012
FIG. 2. Enhanced Nrf2 activity induces earlier onset of IR in Lepob/ob mice. Blood glucose concentration during glucose tolerance test (A) and insulin tolerance test (B) assay from 6-week-old mice (black squares, OB mice; gray squares, OBKeap1-KD mice; n = 5 to 6) is shown. C: Gene expression in SKM (n = 5 to 6). Immunoblot analysis of ser473-phospholylated-Akt (p-Akt), total-Akt (Akt) (D), and Glut4 (E) in SKM of 6-week-old mice is shown. $P < 0.05, Keap1-KD mice compared with WT mice; #P < 0.05, OB mice compared with WT mice; *P < 0.05, OBKeap1-KD mice compared with OB mice. Insr, insulin receptor; Irs, insulin receptor substrate; PGC, peroxisome proliferator–activated receptor γ coactivator; wk, weeks. FIG. 2. Enhanced Nrf2 activity induces earlier onset of IR in Lepob/ob mice. Blood glucose concentration during glucose tolerance test (A) and insulin tolerance test (B) assay from 6-week-old mice (black squares, OB mice; gray squares, OBKeap1-KD mice; n = 5 to 6) is shown. C: Gene expression in SKM (n = 5 to 6). Immunoblot analysis of ser473-phospholylated-Akt (p-Akt), total-Akt (Akt) (D), and Glut4 (E) in SKM of 6-week-old mice is shown. $P < 0.05, Keap1-KD mice compared with WT mice; #P < 0.05, OB mice compared with WT mice; *P < 0.05, OBKeap1-KD mice compared with OB mice. Insr, insulin receptor; Irs, insulin receptor substrate; PGC, peroxisome proliferator–activated receptor γ coactivator; wk, weeks. More
Journal Articles
Journal: Diabetes
Diabetes 2007;56(9):2395–2399
Published: 01 September 2007
... gastric bypass surgery (GBS). Second, the expression of lipin 1 was evaluated in HepG2 cells in response to overexpression of peroxisome proliferatoractivated receptor-γ coactivator (PGC)-1α under normal or hyperinsulinemic conditions. RESULTS— The expression of lipin 1β in liver and adipose tissue...
Includes: Supplementary data
Images
Overview of the role of the ATF/CREB family in the pathway involved in hepa...
Published: 15 February 2021
Figure 1 Overview of the role of the ATF/CREB family in the pathway involved in hepatic gluconeogenesis. The ATF/CREB family members play central roles in hepatic gluconeogenesis as transcriptional regulators. Under fasting conditions, elevated circulating glucagon binds G-protein–coupled receptor... More
Journal Articles
Journal: Diabetes
Diabetes 2006;55(6):1783–1791
Published: 01 June 2006
... is induced in skeletal muscle and brown adipose tissue by conditions associated with enhanced energy expenditure, such as cold exposure or β3-adrenergic agonist treatment. In keeping with the role of peroxisome proliferatoractivated receptor-γ coactivator (PGC)-1α on energy expenditure, we...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(5):1283–1288
Published: 01 May 2006
..., P = 0.32). mRNA of key transcriptional factors and coregulators of mitochondrial biogenesis were also determined. Skeletal muscle mRNA expression of peroxisome proliferatoractivated receptor (PPAR) γ coactivator (PGC)-1α, PGC-1β, PPARδ, nuclear respiratory factor-1, and uncoupling protein-3...
Images
Central nervous system BDNF infusion fails to increase tissue glucose uptak...
Published: 16 April 2013
FIG. 2. Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Tissue glucose uptake (Rg) determined from 2[14C]-deoxyglucose studies in tibialis anterior muscle (A) and BAT (B) and BAT expression of uncoupling protein-1 (Ucp1) (C) and peroxisome proliferator–activated receptor γ-coactivator-1 α (Pgc-1α) (D) in nondiabetic controls or in STZ-induced diabetic animals receiving intracerebroventricular vehicle and pair-fed or intracerebroventricular BDNF (n = 5–6 per group). Data represent mean ± SEM. *P < 0.05 vs. veh-veh. FIG. 2. Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Tissue glucose uptake (Rg) determined from 2[14C]-deoxyglucose studies in tibialis anterior muscle (A) and BAT (B) and BAT expression of uncoupling protein-1 (Ucp1) (C) and peroxisome proliferator–activated receptor γ-coactivator-1 α (Pgc-1α) (D) in nondiabetic controls or in STZ-induced diabetic animals receiving intracerebroventricular vehicle and pair-fed or intracerebroventricular BDNF (n = 5–6 per group). Data represent mean ± SEM. *P < 0.05 vs. veh-veh. More
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Effects of high glucose on glucose metabolism. <em>A</em> and <ital
Published: 01 September 2005
FIG. 2. Effects of high glucose on glucose metabolism. A and B: Expression of glucose metabolic-related proteins. C: GCK immunocytochemistry. Results represent the average ± SE from three independent experiments (*P < 0.005, ** P < 0.05). D: Content of insulin and production of ATP. Results represent the average ± SE from three independent experiments (*P < 0.05, ** P < 0.01; n = 5). All data are representative of three independent experiments. HKI, hexokinase I; PGC-1, peroxisome proliferator–activated receptor γ coactivator 1; PI3K, phosphatidylinositol 3-kinase; SOD, superoxide dismutase; SREBP1, sterol regulatory element–binding protein 1. FIG. 2. Effects of high glucose on glucose metabolism. A and B: Expression of glucose metabolic-related proteins. C: GCK immunocytochemistry. Results represent the average ± SE from three independent experiments (*P < 0.005, ** P < 0.05). D: Content of insulin and production of ATP. Results represent the average ± SE from three independent experiments (*P < 0.05, ** P < 0.01; n = 5). All data are representative of three independent experiments. HKI, hexokinase I; PGC-1, peroxisome proliferator–activated receptor γ coactivator 1; PI3K, phosphatidylinositol 3-kinase; SOD, superoxide dismutase; SREBP1, sterol regulatory element–binding protein 1. More
Journal Articles
Journal: Diabetes
Diabetes 2003;52(3):895–898
Published: 01 March 2003
...Yunhua Li Muller; Clifton Bogardus; Oluf Pedersen; Leslie Baier Peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) is a transcriptional coactivator of peroxisome proliferator-activated receptor γ and α, which play important roles in adipogenesis and lipid metabolism. A single...
Journal Articles
Journal: Diabetes
Diabetes 2019;68(5):918–931
Published: 04 March 2019
.... Overexpression of coactivator peroxisome proliferatoractivated receptor γ coactivator 1-α (PGC-1α), induced physiologically by fasting and pathologically in diabetes, resulted in dramatic downregulation of CYP2R1 in mouse hepatocytes in an estrogen-related receptor α (ERRα)–dependent manner. However, PGC-1α...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2009;58(7):1499–1508
Published: 14 April 2009
...Jennifer L. Estall; Mario Kahn; Marcus P. Cooper; ffolliott Martin Fisher; Michele K. Wu; Dina Laznik; Lishu Qu; David E. Cohen; Gerald I. Shulman; Bruce M. Spiegelman OBJECTIVE The peroxisome proliferatoractivated receptor-γ coactivator (PGC)-1 family of transcriptional coactivators controls...
Journal Articles
Journal: Diabetes
Diabetes 2014;63(11):3615–3625
Published: 13 October 2014
...Hee-Jin Jun; Yagini Joshi; Yuvraj Patil; Robert C. Noland; Ji Suk Chang The transcriptional coactivator peroxisome proliferatoractivated receptor γ coactivator (PGC)-1α and its splice variant N terminal (NT)-PGC-1α regulate adaptive thermogenesis by transcriptional induction of thermogenic...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2014;63(5):1519–1532
Published: 12 April 2014
...-autonomous, because manipulation of Clk2 in hepatocytes controls genes and rates of fatty acid utilization. Clk2 phosphorylation of peroxisome proliferatoractivated receptor γ coactivator (PGC-1α) disrupts its interaction with Mediator subunit 1, which leads to a suppression of PGC-1α activation...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2003;52(12):2874–2881
Published: 01 December 2003
...Aaron P. Russell; Jonas Feilchenfeldt; Sylvia Schreiber; Manu Praz; Antoinette Crettenand; Charles Gobelet; Christoph A. Meier; David R. Bell; Anastasia Kralli; Jean-Paul Giacobino; Olivier Dériaz The peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PGC-1) can induce mitochondria...
Journal Articles
Journal: Diabetes
Diabetes 2015;64(2):418–426
Published: 13 January 2015
... 15744310 16. Vega   RB , Huss   JM , Kelly   DP . The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes . Mol Cell Biol   2000 ; 20 : 1868 – 1876 10669761...
Journal Articles
Journal: Diabetes
Diabetes 2013;62(4):1206–1216
Published: 14 March 2013
... peroxisome proliferatoractivated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coregulator that is recruited to the chromatin where it interacts with the GR and other proteins such as p300 and steroid receptor coactivator 1. This multiprotein complex then regulates gene transcription...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2013;62(4):1297–1307
Published: 14 March 2013
...Li-Na Zhang; Hua-Yong Zhou; Yan-Yun Fu; Yuan-Yuan Li; Fang Wu; Min Gu; Ling-Yan Wu; Chun-Mei Xia; Tian-Cheng Dong; Jing-Ya Li; Jing-Kang Shen; Jia Li Peroxisome proliferatoractivated receptor-γ coactivator-1α (PGC-1α) has been shown to influence energy metabolism. Hence, we explored a strategy...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2016;65(4):861–873
Published: 28 January 2016
... and was identified as a target for the treatment of type 2 diabetes. The regulatory mechanisms controlling Vegfb expression have remained unidentified. We show that peroxisome proliferatoractivated receptor γ coactivator 1α (PGC-1α) together with estrogen-related receptor α (ERR-α) regulates expression...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2007;56(10):2467–2475
Published: 01 October 2007
... of this work was to determine the pattern of genes regulated by peroxisome proliferatoractivated receptor (PPAR) γ coactivator 1α (PGC-1α) in human adipocytes and the involvement of PPARα and PPARγ in PGC-1α transcriptional action. RESEARCH DESIGN AND METHODS— Primary cultures of human adipocytes were...
Includes: Supplementary data