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Potential mechanisms of insulin-mediated neuronal signaling in the control ...
Published: 17 August 2012
FIG. 1. Potential mechanisms of insulin-mediated neuronal signaling in the control of food intake. 1) An increase in insulin-mediated glucose uptake ( 16 ) raises the ATP/ADP ratio, closes KATP channels, depolarizes the plasma membrane, increases Ca2+ entry through voltage-gated channels, and subsequently increases neuronal activity. 2) Direct stimulatory effect on KATP channels ( 17 ). 3) Increased PI3 kinase activity enhancing leptin signaling. 4) Increased transcription of POMC and reduced transcription of NPY genes. IRS, insulin receptor substrate; ATP/ADP, adenosine triphosphate to adenosine diphosphate ratio; K, potassium; POMC, pro-opiomelanocortin; NPY, neuropeptide Y; AgRP, agouti-related peptide; GABA, γ-aminobutyric acid; a-MSH, α-melanocyte–stimulatory hormone; FOXO1, forkhead box protein O1; STAT3, signal transducer and activator of transcription 3; JAK2, Janus kinase 2; PI3K, phosphoinositide 3-kinase. Adapted from ref. 15. FIG. 1. Potential mechanisms of insulin-mediated neuronal signaling in the control of food intake. 1) An increase in insulin-mediated glucose uptake (16) raises the ATP/ADP ratio, closes KATP channels, depolarizes the plasma membrane, increases Ca2+ entry through voltage-gated channels, and subsequently increases neuronal activity. 2) Direct stimulatory effect on KATP channels (17). 3) Increased PI3 kinase activity enhancing leptin signaling. 4) Increased transcription of POMC and reduced transcription of NPY genes. IRS, insulin receptor substrate; ATP/ADP, adenosine triphosphate to adenosine diphosphate ratio; K, potassium; POMC, pro-opiomelanocortin; NPY, neuropeptide Y; AgRP, agouti-related peptide; GABA, γ-aminobutyric acid; a-MSH, α-melanocyte–stimulatory hormone; FOXO1, forkhead box protein O1; STAT3, signal transducer and activator of transcription 3; JAK2, Janus kinase 2; PI3K, phosphoinositide 3-kinase. Adapted from ref. 15. More
Journal Articles
Journal: Diabetes
Diabetes 1998;47(2):294–297
Published: 01 February 1998
... physiological satiety signals. Since α-MSH is coded for by the pro-opiomelanocortin (POMC) gene, we examined if POMC gene expression would be inhibited by fasting in normal mice or in models of obesity characterized by leptin insufficiency (ob/ob) or leptin insensitivity (db/db). In wild-type...
Journal Articles
Journal: Diabetes
Diabetes 1997;46(12):2119–2123
Published: 01 December 1997
...Michael W Schwartz; Randy J Seeley; Stephen C Woods; David S Weigle; L Arthur Campfield; Paul Burn; Denis G Baskin Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that act in the brain to reduce food intake and are potential mediators of leptin action...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(4):828–833
Published: 01 April 1999
... was dure that simultaneously colocalized mRNAs for NPY and pro- observed with a Zeiss Axioplan uorescence microscope, using a uorescein opiomelanocortin (POMC) by uorescence in situ hybridiza- isothiocyanate lter set for Cy2 and a rhodamine lter set for Cy3. Extensive tion (FISH) and Ob-Rb mRNA...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(8):1951–1957
Published: 01 August 2003
... homeostasis in these rats, recombinant adeno-associated virus encoding pro-opiomelanocortin (rAAV-POMC) or control vector was delivered bilaterally into the basal hypothalamus with coordinates targeting the arcuate nucleus. Thirty-eight days after POMC gene delivery, hypothalamic POMC expression increased...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(3):778–783
Published: 01 March 2002
... melanocortin signaling can explain this discrepancy, we used in situ hybridization to compare the effects of STZ-diabetes and fasting on pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) mRNA levels in the hypothalamic arcuate nucleus (ARC) of Npy–/– and Npy...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(11):1890–1896
Published: 01 November 2000
... fasted for 48 h. Serum corticosterone levels increased with fasting, and leptin administration partially normalized them, whereas CNTF administration had no effect. Hypothalamic neuropeptide Y (NPY) and agouti-related protein (AgRP) mRNA expression increased and pro-opiomelanocortin (POMC) decreased...
Journal Articles
Journal: Diabetes
Diabetes 2012;61(9):2216–2218
Published: 17 August 2012
.... IRS, insulin receptor substrate; ATP/ADP, adenosine triphosphate to adenosine diphosphate ratio; K, potassium; POMC, pro-opiomelanocortin; NPY, neuropeptide Y; AgRP, agouti-related peptide; GABA, γ-aminobutyric acid; a-MSH, α-melanocyte–stimulatory hormone; FOXO1, forkhead box protein O1; STAT3...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1796-P
Published: 01 July 2018
...CHUNMEI WANG; YANLIN HE; PINGWEN XU; YONGJIE YANG; YONG XU TAp63 is a transcription factor that has been reported to be important for energy and glucose homeostasis. However, where and how TAp63 functions is unclear. Chow-fed mutant mice with TAp63 deleted from pro-opiomelanocortin (POMC) neurons...
Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2038-P
Published: 01 July 2018
... by hypothalamic pro-opiomelanocortin (POMC) neurons. We then generated mice lacking SRC-2 selectively in POMC neurons. These mutant mice were more resistance to high fat-diet-induced obesity compared to wild type littermates. In addition, we observed that the mutant mice failed to properly suppress energy...
Journal Articles
Journal: Diabetes
Diabetes 2017;66(6):1560–1571
Published: 06 April 2017
... that assesses energy availability by sensing hormones and nutrients to coordinate energy homeostasis. Within the MBH, agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons play critical roles in ingestive behavior. Activation of AgRP neurons rapidly and markedly increases food intake ( 1 – 3...
Journal Articles
Journal: Diabetes
Diabetes 2017;66(3):663–673
Published: 27 December 2016
...-requiring enzyme 1 (Ire1) is required for the proper regulation of energy balance and glucose homeostasis is unclear. We found that pro-opiomelanocortin (Pomc)–specific deficiency of Ire1α accelerated diet-induced obesity concomitant with a decrease in energy expenditure...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1761-P
Published: 01 June 2020
... unclear. We have recently reported that inhibition of hypothalamic pro-opiomelanocortin (POMC) neuronal activity leads to a reduction in blood glucose levels of normoglycemic POMC-cre mice. This effect is independent of energy intake. Since hypothalamic POMC neurons project to the paraventricular nucleus...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(3):735–745
Published: 21 February 2011
... Burcelin; Michael L. Ashford; David Carling; Dominic J. Withers OBJECTIVE AMP-activated protein kinase (AMPK) signaling acts as a sensor of nutrients and hormones in the hypothalamus, thereby regulating whole-body energy homeostasis. Deletion of Ampkα2 in pro-opiomelanocortin (POMC) neurons...
Includes: Supplementary data
Images
PEDF’s metabolic effects do not depend on central actions. <em>A</em>...
Published: 23 April 2011
FIG. 3. PEDF’s metabolic effects do not depend on central actions. A: The hypothalamus of C57Bl/6 mice was excised, and 18S, PEDF, and ATGL mRNA expression were assessed by qRT-PCR (n = 8). B: C57Bl/6 mice were injected with 0.9 μg PEDF or aCSF and placed in a metabolic monitoring station for assessment of oxygen uptake (VO2). C: RER was also assessed (n = 8 for PEDF and n = 11 for vehicle). D: Mice were injected with 0.9 μg PEDF or aCSF, and the hypothalami were excised after 6 h to assess mRNA of hypothalamic neuropeptides that modulate feeding and energy metabolism. Pro-opiomelanocortin (POMC), agouti-related peptide (AgRP), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript (CART) were measured (n = 8 per group). All data are presented as means ± SEM. FIG. 3. PEDF’s metabolic effects do not depend on central actions. A: The hypothalamus of C57Bl/6 mice was excised, and 18S, PEDF, and ATGL mRNA expression were assessed by qRT-PCR (n = 8). B: C57Bl/6 mice were injected with 0.9 μg PEDF or aCSF and placed in a metabolic monitoring station for assessment of oxygen uptake (VO2). C: RER was also assessed (n = 8 for PEDF and n = 11 for vehicle). D: Mice were injected with 0.9 μg PEDF or aCSF, and the hypothalami were excised after 6 h to assess mRNA of hypothalamic neuropeptides that modulate feeding and energy metabolism. Pro-opiomelanocortin (POMC), agouti-related peptide (AgRP), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript (CART) were measured (n = 8 per group). All data are presented as means ± SEM. More
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1920-P
Published: 01 June 2020
...HEE DONG PARK; SUJIN YEO; HYUNSEO PARK; JIN-SOOK PARK; PETER S. HONG Melanocyte-stimulating hormones, neuropeptides induced by Pro-opiomelanocortin (POMC) in the hypothalamus, act as the endogenous ligands of Melanocortin 4 receptor (MC4R). They decrease appetite by MC4R activation, leading...
Journal Articles
Journal: Diabetes
Diabetes 2011;60(3):710–719
Published: 21 February 2011
... of AgRP and α-MSH synthesis for the control of feeding behavior. RESEARCH DESIGN AND METHODS TTF-1 activity in AgRP and pro-opiomelanocortin (POMC) transcription was examined using gel-shift and promoter assays and an in vivo model of TTF-1 synthesis inhibition by intracerebroventricular injection...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):140-OR
Published: 01 June 2020
... a way to strengthen its effect on obesity treatment. It has been reported that the effect of lorcaserin on body weight loss is by activating Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARH). However, how POMCARH neuron activity changes after long term lorcaserin treatment...
Journal Articles
Journal: Diabetes
Diabetes 2001;50(11):2438–2443
Published: 01 November 2001
... implicated as possible targets of orexigenic peptides ( 1 ). These include neuropeptide Y (NPY)/agouti-related protein (AGRP) coexpressing neurons, pro-opiomelanocortin (POMC) neurons, and growth hormone–releasing hormone (GHRH) neurons, which are known to be stimulated (NPY and AGRP) or suppressed (POMC...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(5):872–875
Published: 01 May 2000
..., mutations in the genes (CART) peptide is a recently characterized neuropep- encoding leptin (3,4), leptin receptor (5), prohormone con- tide implicated in the control of appetite. We hypothe- vertase (PC)-1 (6), pro-opiomelanocortin (POMC) (7), and the sized that genetic variation in CART may contribute...