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socs-suppressor-cytokine-signaling

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Journal Articles
Journal: Diabetes
Diabetes 2001;50(12):2744–2751
Published: 01 December 2001
.... In this study, we have shown that IFN-γ signaling, measured by signal transducer and activator of transcription-1 (STAT1) activation and the expression of IFN-γ–responsive genes, is persistent in β-cells for as long as the cytokine is present. Because members of the suppressor of cytokine signaling (SOCS...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(11):2696–2700
Published: 01 November 2003
... unresolved is whether cytokines play a direct role in β-cell death. We investigated whether β-cell cytokine signaling contributes to autoimmune type 1 diabetes. We demonstrated that NOD mice harboring β-cells expressing the suppressor of cytokine signaling-1 (SOCS-1), an inhibitor of Janus kinase/signal...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(9):2232–2241
Published: 01 September 2004
... myotubes and whether suppressor of cytokine signaling 3 (SOCS-3) could be related to insulin resistance in vivo in humans. IL-6 inhibited insulin signaling and induced SOCS-3 expression in differentiated myotubes. SOCS-3 mRNA levels were significantly increased in the skeletal muscle of type 2 diabetic...
Journal Articles
Journal: Diabetes
Diabetes 2004;53(suppl_3):S97–S103
Published: 01 December 2004
... of the insulin receptor (IR) and insulin receptor substrate (IRS) proteins as well as phosphatidylinositol 3-kinase (PI3K) activation, and that this action is not due to the IL-1β-dependent nitric oxide (NO) production in RINm5F cells. We next analyzed if suppressor of cytokine signaling (SOCS)-3, which can...
Journal Articles
Journal: Diabetes
Diabetes 2012;61(6):1434–1443
Published: 14 May 2012
.../PSEN1dE9 transgenic AD model mice with increased plasma Aβ40/42 levels show impaired glucose and insulin tolerance and hyperinsulinemia. Furthermore, Aβ impairs insulin signaling in mouse liver and cultured hepatocytes. Aβ can upregulate suppressors of cytokine signaling (SOCS)-1, a well-known insulin...
Includes: Supplementary data
Journal Articles
Journal: Diabetes
Diabetes 2010;59(12):3074–3084
Published: 28 September 2010
... and leptin resistance. Suppressor of cytokine signaling (SOCS)-3 and protein-tyrosine phosphatase 1B (PTP-1B) are two endogenous inhibitors of tyrosine kinase signaling pathways and suppress both insulin and leptin signaling via different molecular mechanisms. Brain-specific inactivation of these genes...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(11):1890–1896
Published: 01 November 2000
... expression of hypothalamic inhibitors of leptin and CNTF signaling (suppressor of cytokine signaling 3 [SOCS-3]) and mediators of energy expenditure (cyclo-oxygenase 2 [COX-2]), we studied the effect of CNTF and leptin administered by intraperitoneal injections (1 microg/g twice daily) in C57Bl/6J mice...
Journal Articles
Journal: Diabetes
Diabetes 2008;57(6):1651–1658
Published: 01 June 2008
...Xuebin Liu; Marie G. Mameza; Yun Sang Lee; Chikezie I. Eseonu; Cheng-Rong Yu; Jennifer J. Kang Derwent; Charles E. Egwuagu OBJECTIVE— Suppressors of cytokine signaling (SOCS) are implicated in the etiology of diabetes, obesity, and metabolic syndrome. Here, we show that some SOCS members...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2020;69(Supplement_1):290-OR
Published: 01 June 2020
...+ T cells. Islet infiltrating T cells from Ifngr mutant mice had increased responses to common gamma chain (γc) cytokines, prevented by a JAKi, and reduced expression of suppressor of cytokine signalling-1 (Socs1) mRNA. Our data suggest that as well as its pro-inflammatory effects, IFN-γ...
Journal Articles
Journal: Diabetes
Diabetes 2013;62(1):56–64
Published: 13 December 2012
... is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin signal transduction...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1910-P
Published: 01 June 2019
...KAORI CHO; TAKASHI USHIKI; HAJIME ISHIGURO; TAKAYUKI KATAGIRI; TATSUYA SUWABE; HIDEYO HIRAI; YOSHIMI NAKAGAWA; MASAYOSHI MASUKO; WARREN ALEXANDER; HITOSHI SHIMANO; HIROHITO SONE Introduction: Suppressors of cytokine signaling (SOCS) are negative regulators of cytokine signaling; SOCS3 controls...
Journal Articles
Journal: Diabetes
Diabetes 2003;52(8):2025–2034
Published: 01 August 2003
...-cell survival after infection by the human pathogen CVB3, cytomegalovirus (CMV), and lymphocytic choriomeningitis virus (LCMV). We demonstrated that mice harboring β-cells that do not respond to IFN because of the expression of the suppressor of cytokine signaling-1 (SOCS-1) succumb to an acute form...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(9):2412–2418
Published: 01 September 2006
... to Fas ligation were not protected from diabetes. We next investigated the mechanism of protection provided by overexpression of suppressor of cytokine signaling-1 (SOCS-1) in β-cells of NOD8.3 mice. SOCS-1 islets remained intact when grafted into NOD8.3 mice and were less efficiently killed in vitro...
Meeting Abstracts
Journal: Diabetes
Diabetes 2001;50(suppl_1):S25
Published: 01 February 2001
.... The implication of the discovery of suppressors of cytokine signaling (SOCS) proteins for the interaction between stimulatory and inhibitory cytokines, including GH, PRL, leptin, and the proinflammatory cytokines interleukin-1 and interferon-gamma, in beta-cell survival is not yet clear. Recent studies indicate...
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):310-LB
Published: 01 June 2019
... is an adipocyte-derived hormone that suppresses food intake and stimulates energy expenditure, leading to a reduction in stored body fat. However, patients with obesity have high levels of leptin, resulting in expression of suppressor of cytokine signaling (SOCS) 3 which is a negative feedback regulator of janus...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(12):3410–3417
Published: 01 December 2005
... of transcription (STAT)3 and STAT5b in INS-1 β-cells. Leptin also induced mRNA expression of the JAK-STAT inhibitor suppressor of cytokine signaling (SOCS)3 in INS-1 β-cells and human pancreatic islets in vitro and in pancreatic islets of ob/ob mice in vivo. Transcriptional activation of the rat SOCS3...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(3):699–707
Published: 01 March 2006
...Hang Shi; Belinda Cave; Karen Inouye; Christian Bjørbæk; Jeffrey S. Flier In adipocytes, suppressor of cytokine signaling (SOCS)3 deficiency increases insulin-stimulated insulin receptor substrate (IRS)-1 and -2 phosphorylation, IRS-associated phosphatidylinositol 3 kinase activity, and insulin...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(3):795–803
Published: 01 March 2007
... insulin sensitivity is not fully understood. Recent studies have shown that the induction of suppressor of cytokine signaling 3 (SOCS3) is related to the development of insulin resistance. Here, we examined whether the insulin-sensitizing effect of pioglitazone affects the SOCS induction. In db...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(2):541–548
Published: 01 February 2007
... blocks cytokine-induced SOCS expression ( 7 , 16 , 17 ). In this review we focus on a group of proteins, the suppressors of cytokine signaling (SOCS), which affect cytokine signaling and appear to play an important role in the pathological processes leading to both type 1 and type 2 diabetes...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(8):2396–2403
Published: 01 August 2005
... be terminated by overexpression of suppressor of cytokine signaling-1. Diabetes   50 : 2744 –2751, 2001 36. Karlsen AE, Ronn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N: Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against...