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uae-urinary-albumin-excretion

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Meeting Abstracts
Journal: Diabetes
Diabetes 2018;67(Supplement_1):339-OR
Published: 01 July 2018
... creatinine and cystatin C. HTN was defined as systolic (SBP) or diastolic blood pressure (DBP) ≥130/80 mm Hg and elevated albumin excretion (UAE) as ACR ≥30mg/g. Mean arterial pressure (MAP) was calculated ([SBP + 2 (DBP)]/3). Generalized estimating equations and Cox proportional hazard models evaluated...
Journal Articles
Journal: Diabetes
Diabetes 1992;41(5):581–586
Published: 01 May 1992
...Pascale H Lane; Michael W Steffes; S Michael Mauer Eight women with insulin-dependent diabetes mellitus (IDDM) with low creatinine clearance rate (CCR) and normal urinary albumin excretion (UAE) were compared with three other groups of diabetic women: 19 with normal creatinine clearance rate (CCR...
Journal Articles
Journal: Diabetes
Diabetes 1994;43(10):1248–1253
Published: 01 October 1994
...Per L Poulsen; Klavs W Hansen; Carl E Mogensen To describe the development in blood pressure (BP) in relation to urinary albumin excretion (UAE) more exactly, 44 initially normoalbuminuric type I diabetic patients and 21 healthy individuals were included in a 3.1-year follow-up study by using...
Journal Articles
Journal: Diabetes
Diabetes 1990;39(9):1057–1063
Published: 01 September 1990
... to advanced nephropathy. The clinical parameters were (ranges, with medians in parentheses) urinary albumin excretion (UAE) 158–5494 μg/min (1153 μg/min), glomerular filtration rate (GFR) 30–128 ml · min −1 · 1.73 m−2 (90 mh ml · min−1 · 1.73 m−2) and mean arterial...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(9):1489–1493
Published: 01 September 1998
... River Indian Community of Arizona. Subjects' exposure to diabetes in utero was established from periodic examinations conducted as part of the study. The prevalence of elevated urinary albumin excretion (UAE) (albumin-to-creatinine ratio > or = 30 mg/g) was 40% (83 of 207) in the offspring...
Journal Articles
Journal Articles
Journal: Diabetes
Diabetes 1978;27(9):959–964
Published: 01 September 1978
...S Michael Mauer, MD; David M Brown, MD; Arthur J Matas, MD; Michael W Steffes, MD,PhD The effects of reduced renal mass and of islet transplantation on urinary albumin excretion (UAE) rates in diabetic rats were examined. Increased UAE rates were noted two months after the induction...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(6):1057–1063
Published: 01 June 2000
...D G Fogarty; L S Hanna; M Wantman; J H Warram; A S Krolewski; S S Rich Elevated urinary albumin excretion (UAE) is a predictor of the development of nephropathy and cardiovascular mortality. To study whether genetic factors may determine UAE, we examined familial aggregation of UAE in 96 large...
Journal Articles
Journal: Diabetes
Diabetes 2005;54(11):3326–3330
Published: 01 November 2005
... 2005 ESRD, end-stage renal disease FABP2, fatty acid–binding protein-2 IHD, ischemic heart disease SNP, single nucleotide polymorphism UAE, urinary albumin excretion Diabetic nephropathy develops in up to 40% of diabetic patients at most, even when high glucose levels are maintained...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(8):2653–2657
Published: 01 August 2002
... years), the Pro12Ala genotype distribution was in Hardy-Weinberg equilibrium (P = 0.42). The Ala12 allele frequency was 0.14. With adjustment for covariables, the 118 Ala12 allele carriers had significantly lower urinary albumin excretion (UAE) than the 327 noncarriers (17.1 vs. 25.8 mg/d...
Journal Articles
Journal: Diabetes
Diabetes 1994;43(3):441–446
Published: 01 March 1994
...). Abnormalities in VvMes/Glom and SvPGBM/Glom were more pronounced in patients with both retinopathy and hypertension. Four of the 15 patients (27%) with either normal urinary albumin excretion (UAE) or low-level microalbuminuria had advanced retinopathy but normal VvMes/Glom. In conclusion, the presence...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(2):377–382
Published: 01 February 1999
...) on renal/glomerular hypertrophy and urinary albumin excretion (UAE), streptozotocin-induced diabetic and nondiabetic mice were injected with G120K-PEG every 2nd day for 28 days. Placebo-treated diabetic and nondiabetic animals were used as reference groups. Placebo-treated diabetic animals were...
Journal Articles
Journal: Diabetes
Diabetes 2002;51(10):3090–3094
Published: 01 October 2002
...-treated db/db mice showed a pronounced increase in kidney weight, glomerular volume, basement membrane thickness (BMT), total mesangial volume, urinary albumin excretion (UAE), and creatinine clearance (CrCl) when compared with nondiabetic controls. In VEGF antibody-treated db/db mice...
Images
BI-2536 improves kidney function and ameliorates glomerular hypertrophy and...
Published: 16 October 2020
Figure 4 BI-2536 improves kidney function and ameliorates glomerular hypertrophy and mesangial matrix expansion in diabetic OVE26 mice. Renal function and histopathology of control mice (WT), OVE26 and OVE26 mice, and OVE26 mice treated with BI-2536 (OVE26+BI-2536). n = 6–8 mice per group. A: Urinary ACR (UCAR) (mg/mg) in mice 8–16 weeks of age. B: 24-h urinary albumin excretion (UAE) (mg) at 16 weeks of age. C: blood urea nitrogen (BUN) levels at 16 weeks of age. D: Representative low- and high-magnification images of PAS-stained kidney sections of mice at 16 weeks of age. Scale bars, 50 μm (top) and 20 μm (bottom). E: Quantification of glomerular volume (GV) and mesangial matrix fraction. n = 6–8 mice per group, with at least 30 glomeruli scored per mouse. *P < 0.05, ***P < 0.001, and ****<0.0001 vs. WT and #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. OVE26 by ANOVA with Tukey multiple comparison test. wks, weeks. Figure 4. BI-2536 improves kidney function and ameliorates glomerular hypertrophy and mesangial matrix expansion in diabetic OVE26 mice. Renal function and histopathology of control mice (WT), OVE26 and OVE26 mice, and OVE26 mice treated with BI-2536 (OVE26+BI-2536). n = 6–8 mice per group. A: Urinary ACR (UCAR) (mg/mg) in mice 8–16 weeks of age. B: 24-h urinary albumin excretion (UAE) (mg) at 16 weeks of age. C: blood urea nitrogen (BUN) levels at 16 weeks of age. D: Representative low- and high-magnification images of PAS-stained kidney sections of mice at 16 weeks of age. Scale bars, 50 μm (top) and 20 μm (bottom). E: Quantification of glomerular volume (GV) and mesangial matrix fraction. n = 6–8 mice per group, with at least 30 glomeruli scored per mouse. *P < 0.05, ***P < 0.001, and ****<0.0001 vs. WT and #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. OVE26 by ANOVA with Tukey multiple comparison test. wks, weeks. More
Images
CCK-8S ameliorates <span class="search-highlight">urinary</span> <span class="search-highlight">albumin</span> <span class="search-highlight">excretion</span> and inhibits macrophage infilt...
Published: 14 March 2012
FIG. 4. CCK-8S ameliorates urinary albumin excretion and inhibits macrophage infiltration in glomeruli. A: Time course of urinary albumin excretion (UAE). The UAE of untreated diabetic rats (DM; ○) was increased progressively compared with that in nondiabetic rats (NDM; △), whereas it was suppressed in CCK-8S–treated diabetic rats (DM-CCK; ●) at week 8 (n = 7/group). Values are the means ± SEM. *P < 0.05 vs. NDM; ***P < 0.001 vs. NDM; ††P < 0.01 vs. DM-CCK. B: There was no difference in the amount of food intake between DM (○) and DM-CCK (●). ***P < 0.001 vs. DM and DM-CCK. Values are the means ± SEM. C: PAM staining of the kidney at 8 weeks. D: Glomerular hypertrophy was observed in both diabetic groups as compared with nondiabetic rats. Values are the means ± SEM. ***P < 0.001. E: Mesangial matrix index was ameliorated in CCK-8S–treated diabetic rats compared with untreated diabetic rats. Values are the means ± SEM. ***P < 0.001. Fifteen randomly selected glomeruli per rat were examined (n = 5/group). F: Expression of type IV collagen in kidney tissue. G: Type IV collagen-positive area in glomeruli (folds versus NDM). Type IV collagen was significantly increased in the DM compared with the DM-CCK group. Fifteen randomly selected glomeruli per rat were examined (n = 4/group). Values are the means ± SEM. ***P < 0.001. H: Macrophage infiltration into glomeruli at 8 weeks. Arrowheads indicate macrophages. I: The average number of intraglomerular macrophages. Macrophage infiltration into glomeruli was remarkable in the DM, whereas it was minimal in the DM-CCK group. Twenty randomly selected glomeruli per rat were examined (n = 4/group). Values are the means ± SEM. ***P < 0.001. J: Expression of WT-1 in glomeruli. K: The average number of WT-1–positive cells in glomeruli. Podocyte loss was inhibited in CCK-8S–treated diabetic rats compared with untreated diabetic rats. Twenty randomly selected glomeruli per rat were examined (n = 4/group). Values are the means ± SEM. ***P < 0.001. Scale bars, 50 μm. (A high-quality digital representation of this figure is available in the online issue.) FIG. 4. CCK-8S ameliorates urinary albumin excretion and inhibits macrophage infiltration in glomeruli. A: Time course of urinary albumin excretion (UAE). The UAE of untreated diabetic rats (DM; ○) was increased progressively compared with that in nondiabetic rats (NDM; △), whereas it was suppressed in CCK-8S–treated diabetic rats (DM-CCK; ●) at week 8 (n = 7/group). Values are the means ± SEM. *P < 0.05 vs. NDM; ***P < 0.001 vs. NDM; ††P < 0.01 vs. DM-CCK. B: There was no difference in the amount of food intake between DM (○) and DM-CCK (●). ***P < 0.001 vs. DM and DM-CCK. Values are the means ± SEM. C: PAM staining of the kidney at 8 weeks. D: Glomerular hypertrophy was observed in both diabetic groups as compared with nondiabetic rats. Values are the means ± SEM. ***P < 0.001. E: Mesangial matrix index was ameliorated in CCK-8S–treated diabetic rats compared with untreated diabetic rats. Values are the means ± SEM. ***P < 0.001. Fifteen randomly selected glomeruli per rat were examined (n = 5/group). F: Expression of type IV collagen in kidney tissue. G: Type IV collagen-positive area in glomeruli (folds versus NDM). Type IV collagen was significantly increased in the DM compared with the DM-CCK group. Fifteen randomly selected glomeruli per rat were examined (n = 4/group). Values are the means ± SEM. ***P < 0.001. H: Macrophage infiltration into glomeruli at 8 weeks. Arrowheads indicate macrophages. I: The average number of intraglomerular macrophages. Macrophage infiltration into glomeruli was remarkable in the DM, whereas it was minimal in the DM-CCK group. Twenty randomly selected glomeruli per rat were examined (n = 4/group). Values are the means ± SEM. ***P < 0.001. J: Expression of WT-1 in glomeruli. K: The average number of WT-1–positive cells in glomeruli. Podocyte loss was inhibited in CCK-8S–treated diabetic rats compared with untreated diabetic rats. Twenty randomly selected glomeruli per rat were examined (n = 4/group). Values are the means ± SEM. ***P < 0.001. Scale bars, 50 μm. (A high-quality digital representation of this figure is available in the online issue.) More
Journal Articles
Journal: Diabetes
Diabetes 2004;53(1):166–172
Published: 01 January 2004
... in kidney weight, glomerular volume, basement membrane thickness (BMT), total mesangial volume, urinary albumin excretion (UAE), and creatinine clearance compared with nondiabetic controls. In RAGE antibody–treated db/db mice, the increase in kidney weight, glomerular volume, mesangial volume...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(3):423–430
Published: 01 March 1998
...A Giustina; P Perini; P Desenzani; S Bossoni; P Ianniello; M Milani; G Davì; G Romanelli Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest...
Journal Articles
Journal: Diabetes
Diabetes 2006;55(1):225–233
Published: 01 January 2006
... and type 2 diabetes. Podocyte apoptosis coincided with the onset of urinary albumin excretion (UAE) and preceded significant losses of podocytes in Akita (37% reduction) and db/db (27% reduction) mice. Increased extracellular glucose (30 mmol/l) rapidly stimulated generation of intracellular...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 2019;68(Supplement_1):503-P
Published: 01 June 2019
... glucose (FBG), serum uric acid (SUA), serum creatinine (SCr), and blood urea nitrogen (BUN). Simultaneous urinary samples were tested and daily urinary amount of albumin (UAE), uric acid (UUA), creatinine (UCR), urea nitrogen (UUN) were calculated. Gene expressions of GLUT9, xanthine oxidase (XO), urate...
Journal Articles
Journal: Diabetes
Diabetes 1993;42(1):178–182
Published: 01 January 1993
...-insulin-dependent diabetes mel- litus; UAE, urinary albumin excretion; BMI, body mass index; type I diabetes, insulin-dependent diabetes mellitus; BP, blood pressure; sBP, systolic blood pressure; ACE, angiotensin converting enzyme; RIA, radioimmunoassay; CV, coefficient of variation; PDGF, platelet...