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ucp-uncoupling-protein

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Interaction of glucose and fatty acid metabolism in muscle. <span class="search-highlight">UCP</span>, <span class="search-highlight">uncoupling</span>...
Published: 01 January 2002
FIG. 6. Interaction of glucose and fatty acid metabolism in muscle. UCP, uncoupling protein; FA, fatty acids. Note that in this model, emphasis is placed on ACC2, the predominant form in muscle. However, it is recognized that ACC1 is also expressed in this tissue, and its contribution should be co... More
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Schematic overview summarizing our proposed model for the molecular mechani...
Published: 22 March 2011
FIG. 6. Schematic overview summarizing our proposed model for the molecular mechanisms initiated by the activation of the ghrelin receptor leading to AMPK activation and finally to an increased feeding behavior. ROS, reactive oxygen species; CPT, carnitine palmitoyltransferase; UCP, uncoupling pro... More
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Major ROS generated within renal cells in diabetic milieu and the classic a...
Published: 01 June 2008
FIG. 1. Major ROS generated within renal cells in diabetic milieu and the classic antioxidant pathways for their detoxification. I, NADH dehydrogenase (complex I); II, succinate reductase (complex II); III, ubiquinol-cytochrome C reductase (complex III); IV, cytochrome oxidase (complex IV); V, ATP synthase; ADP/ATP, adenosine bi(tri)phosphate; FADH2, flavin adenine dinucleotide; GPx, glutathione peroxidase; NADH, nicotinamide adenine dinucleotide (reduced form); UCP, uncoupling protein; ·O2 superoxide radical; ·OH, hydroxyl radical; H2O2, hydrogen peroxide; ·NO, nitric oxide; ONOO, peroxynitrite radical. FIG. 1. Major ROS generated within renal cells in diabetic milieu and the classic antioxidant pathways for their detoxification. I, NADH dehydrogenase (complex I); II, succinate reductase (complex II); III, ubiquinol-cytochrome C reductase (complex III); IV, cytochrome oxidase (complex IV); V, ATP synthase; ADP/ATP, adenosine bi(tri)phosphate; FADH2, flavin adenine dinucleotide; GPx, glutathione peroxidase; NADH, nicotinamide adenine dinucleotide (reduced form); UCP, uncoupling protein; ·O2− superoxide radical; ·OH, hydroxyl radical; H2O2, hydrogen peroxide; ·NO, nitric oxide; ONOO−, peroxynitrite radical. More
Journal Articles
Journal: Diabetes
Diabetes 1997;46(5):900–906
Published: 01 May 1997
...Ruth E Gimeno; Marlene Dembski; Xun Weng; Nanhua Deng; Andrew W Shyjan; Carlos J Gimeno; Francois Iris; Stephen J Ellis; Elizabeth A Woolf; Louis A Tartaglia We have identified a novel cDNA encoding a protein highly homologous to the mammalian brown fat uncoupling protein (UCP). Unlike the known...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(5):1020–1025
Published: 01 May 1999
...M Y Wang; M Shimabukuro; Y Lee; K Y Trinh; J L Chen; C B Newgard; R H Unger The discovery of uncoupling protein (UCP)-2, a ubiquitously expressed protein homologous to UCP-1, has raised the possibility that energy balance of cells might be regulated in tissues other than brown adipocytes. In normal...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(9):1528–1531
Published: 01 September 1998
...A Krook; J Digby; S O'Rahilly; J R Zierath; H Wallberg-Henriksson Two recently described proteins in the mitochondrial uncoupling protein (UCP) family, UCP-2 and UCP-3, have been linked to phenotypes of obesity and NIDDM. We determined the mRNA levels of UCP-2 and UCP-3 in skeletal muscle of NIDDM...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(7):1482–1486
Published: 01 July 1999
...C B Chan; P E MacDonald; M C Saleh; D C Johns; E Marbàn; M B Wheeler Uncoupling protein 2 (UCP-2) mRNA expression has been shown to be altered by metabolic conditions such as obesity in humans, but its functional significance is unknown. The expression of UCP-2 mRNA and protein in normal rat islets...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(11):1693–1698
Published: 01 November 1998
.... Interorgan Signaling Between Adipose Tissue Metabolism and Skeletal Muscle Uncoupling Protein Homologs Is There a Role for Circulating Free Fatty Acids? Sonia Samec, Josiane Seydoux, and Abdul G. Dulloo Uncoupling proteins 3 and 2 (UCP3 and UCP2) are two changes in body fat stores and UCP expression in pre...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(1):25–31
Published: 01 January 2000
...Y Khalfallah; S Fages; M Laville; D Langin; H Vidal To study the effect of nonesterified fatty acids (NEFAs) on uncoupling protein-2 (UCP-2) and uncoupling protein-3 (UCP-3) gene expression, a triglyceride emulsion was infused for 5 h in 14 healthy volunteers. A euglycemic-hyperinsulinemic clamp...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(7):1101–1105
Published: 01 July 2000
... at mimicking leptin-induced hyperphagia, produced a marked decrease in the expression of muscle uncoupling protein-3 (UCP-3), whereas ICV infusion of leptin prevented such a decrease in UCP-3. To investigate an involvement of thyroid hormones in this effect of leptin, plasma levels of these hormones were...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(5):840–842
Published: 01 May 1998
... Polymorphisms and Obesity in French Caucasians Shuichi Otabe, Karine Clement, Nathalie Rich, Craig Warden, Claire Pecqueur, Maria Neverova, Serge Raimbault, Bernard Guy-Grand, Arnaud Basdevant, Daniel Ricquier, Philippe Froguel, and Francis Vasseur Uncoupling proteins (UCPs) are inner mitochon- regions of human...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(7):1224–1230
Published: 01 July 2000
...N Pedraza; G Solanes; M C Carmona; R Iglesias; O Viñas; T Mampel; M Vazquez; M Giralt; F Villarroya The expression of uncoupling protein (UCP)-3 mRNA in skeletal muscle is dramatically reduced during lactation in mice. The reduction in UCP-3 mRNA levels lowers the amount of the UCP-3 protein...
Journal Articles
Journal: Diabetes
Diabetes 2007;56(10):2457–2466
Published: 01 October 2007
... production was increased. Mitochondria from db/db mice exhibited fatty acid–induced mitochondrial uncoupling that is inhibitable by GDP, suggesting that these changes are mediated by uncoupling proteins (UCPs). Mitochondrial uncoupling was not associated with an increase in UCP content, but fatty...
Includes: Supplementary data
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(2):436–441
Published: 01 February 1999
...S Samec; J Seydoux; A G Dulloo UCP2 and UCP3 are two recently cloned genes with high sequence homology to the gene for uncoupling protein (UCP)-1, which regulates thermogenesis in brown adipose tissue. In the context of the current debate about whether UCP2 and UCP3 in the skeletal muscle may also...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(12):1935–1940
Published: 01 December 1998
...S Bao; A Kennedy; B Wojciechowski; P Wallace; E Ganaway; W T Garvey To explore the potential role of the uncoupling protein (UCP) family in human obesity and diabetes, we have used the reverse transcription-polymerase chain reaction to quantify UCP mRNA expression in human skeletal muscle. Levels...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(1):128–133
Published: 01 January 1999
... and increased whole-body glucose turnover in C57Bl/6J mice (Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377, 1997). We extended the previous study by measuring steady-state levels of uncoupling protein (UCP)-2...
Meeting Abstracts
Journal: Diabetes
Diabetes 2000;49(3):319–324
Published: 01 March 2000
... a nutrient-sensing pathway is activated by an increased availability of lipid fuels in nine normal weight male volunteers. Using reverse transcriptase-polymerase chain reaction analysis, the mRNA expression of fatty acid translocase (FAT)/CD36, PPAR-gamma2, leptin, uncoupling protein (UCP)-2 and UCP-3...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(2):430–435
Published: 01 February 1999
... uncoupling proteins (UCPs) are subject to transcriptional regulation in diabetes, we examined changes in UCP mRNA expression in the heart of streptozotocin-induced diabetic (STZ-DM) rats. Heart UCP3 mRNA expression significantly increased by 9.4-fold in STZ-DM rats, while levels of UCP2 mRNA expression were...
Meeting Abstracts
Journal: Diabetes
Diabetes 1998;47(4):685–687
Published: 01 April 1998
.../diabetes/appendix.htm. PCR, polymerase chain reaction; UCP, uncoupling protein. DIABETES, VOL. 47, APRIL 1998 685 HUMAN UCP2 GENE STRUCTURE AND POLYMORPHISM FIG. 1. Schematic representation of the exon-intron structure of the human uncoupling protein 2 gene (UCP2). The sizes of the six coding exons...
Meeting Abstracts
Journal: Diabetes
Diabetes 1999;48(2):365–370
Published: 01 February 1999
..., hypertriglyceridemia, and hyperleptinemia, three salient abnormalities of obesity syndromes. Central glucocorticoid infusion also produced a marked decrease in the expression of uncoupling protein (UCP)-1 and UCP-3 in brown adipose tissue and UCP-3 in muscle. Finally, chronic central glucocorticoid administration...