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Special Edition: Reduction of Residual Risk in Cardiovascular Disease: Focus on Triglycerides

This special series of Diabetes Core Update is supported by an independent educational grant from Amarin Corp.

For more than 30 years, statins have been the cornerstone of lipid management to reduce the risk of cardiovascular disease (CVD) and heart-related events. These medications have been proven to effectively lower LDL cholesterol levels and CVD risk in a wide array of patient populations. But even after patients meet their LDL cholesterol goals, the risk for CVD-related events isn’t completely abolished—a significant “residual risk” remains in most populations.

In this special four-episode series made possible by an unrestricted educational grant from Amarin Corp, Diabetes Core Update will explore the concept of residual risk in CVD, while specifically discussing the role of triglycerides as a CVD risk factor and a target to reduce residual risk. Dr. Neil Skolnik is joined by Dr. Christie Ballantyne (Professor of Medicine-Cardiology and Director of the Center for Cardiometabolic Disease Prevention, Baylor College of Medicine) and Dr. Charles Vega (Clinical Professor of Family Medicine and Associate Dean in the School of Medicine at the University of California, Irvine) to discuss the concept of residual risk, reducing residual risk, how to optimize cardiovascular risk reduction and when to address various factors, the role of high triglycerides in relation to other risk factors, and common clinical cases and real-world challenges to optimally reduce CVD risk in various patient populations.

Please listen to each episode by clicking on the podcast players below or by freely subscribing to Diabetes Core Update via Apple Podcasts, Amazon Music, Spotify, or your preferred podcast platform.

Play Episode

Total Time: 30:38 | File Size: 42.0 MB

In this special episode on Residual Risk: A Focus on Triglycerides, our host, Dr. Neil Skolnik will discuss Metabolic Syndrome: A Focus on Triglycerides with Dr. Peter Toth. Dr. Toth is Director of Preventive Cardiology, CGH Medical Center, and an adjunct professor of medicine at Johns Hopkins Medical School.

This special episode is supported by an independent educational grant from Amarin.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Peter Toth, M.D., PhD, Director of Preventive Cardiology, CGH Medical Center, Adjunct Professor of Medicine, Johns Hopkins Medical School.


REFERENCES AND RELATED RESOURCES

Icosapent Ethyl: REDUCE-IT: N Engl J Med 2019;380:11-22

Omega-3 Fatty Acids: STRENGTH trial - JAMA 2020;324(22):2268-2280

Pemafibrate: PROMINENT - N Engl J Med 2022;387:1923-1934

Icosapent Ethyl: JELIS - Lancet. 2007;369(9567):1090-1098

Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort study: BMJMED 2024;3:e000451


Play Episode

Total Time: 28:08 | File Size: 39.0 MB

In this special episode on Residual Risk: A Focus on Triglycerides, our host, Dr. Neil Skolnik will discuss Residual Risk, Triglycerides and how to reduce residual risk with Dr. Charles Vega, Clinical Professor of Family Medicine and Associate Dean in the School of Medicine at the University of California, Irvine.

This special episode is supported by an independent educational grant from Amarin.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Charles Vega, M.D., Clinical Professor of Family Medicine, Director, UC Irvine Program in Medical Education for the Latino Community, and Associate Dean in the School of Medicine at the University of California, Irvine.


REFERENCES AND RELATED RESOURCES

Icosapent Ethyl: REDUCE-IT: N Engl J Med 2019; 380:11-22

ADA Standards of Care: Diabetes Care 2023;46(Supplement_1):S158–S190

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease:: Circulation. 2023;148. doi: 10.1161/CIR.0000000000001168

See Episode 1 for further references.


Play Episode

Total Time: 24:43 | File Size: 34.3 MB

In this special episode on Residual Risk: A Focus on Triglycerides, our host, Dr. Neil Skolnik will discuss Residual Risk, Triglycerides and how to reduce residual risk with Dr. Christie Ballantyne, Director of the Center for Cardiometabolic Disease Prevention, Baylor College of Medicine.

This special episode is supported by an independent educational grant from Amarin.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Dr. Christie Ballantyne. Dr. Ballantyne is a Professor of Medicine-Cardiology, and Director of the Center for Cardiometabolic Disease Prevention, Baylor College of Medicine.


REFERENCES AND RELATED RESOURCES

Niacin: AIM-HIGH - N Engl J Med 2011; 365:2255-2267

Omega-3 Fatty Acids: STRENGTH trial - JAMA. 2020;324(22):2268-2280

Pemafibrate: PROMINENT - N Engl J Med 2022; 387:1923-1934

Icosapent Ethyl: JELIS - Lancet. 2007;369(9567):1090-1098

Icosapent Ethyl: REDUCE-IT - N Engl J Med 2019; 380:11-22

ADA Standards of Care: Diabetes Care 2023;46(Supplement_1):S158–S190

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: Circulation. 2023;148. doi: 10.1161/CIR.0000000000001168


Diabetes Core Update is a monthly audio podcast devoted to presenting and discussing the latest clinically relevant articles from ADA’s four scholarly journals: Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Users can freely access previous episodes of Diabetes Core Update here.

For previous episodes, please visit:

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