In Brief The epidemic rise in diabetes in the United States has prompted scientists to expand the search for modifiable risk factors, for both the disease itself and associated morbidity. In this From Research to Practice section, the authors review mounting evidence pointing toward depression as a medical risk factor for the development of type 2 diabetes and for progression of complications from either type 1 or type 2 diabetes. They offer practical advice for the management of depression in patients with diabetes, including 1) how to identify people in need of help, 2) how to get people to accept the help they need, and 3) what to expect from treatment options in the practice setting.

Note of disclosure: The authors receive research support from GlaxoSmithKline, makers of pharmaceutical products for the treatment of depression and diabetes.