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TABLE 3

Hyperinsulinemic euglycemic clamp data and effects of salt loading on hepatic glucose production and glucose uptake into skeletal muscle

2 weeks salt loading
8 weeks salt loading
ControlsHigh salt–fed ratsControlsHigh salt–fed rats
n 
Plasma insulin (ng/dl) 325 ± 34 321 ± 35 315 ± 35 345 ± 37 
Blood glucose (mmol/l) 5.60 ± 0.34 5.53 ± 0.38 5.53 ± 0.29 5.49 ± 0.36 
Glucose infusion rate 29.4 ± 3.8 15.5 ± 5.8* 16.5 ± 0.6 11.2 ± 1.2 
 (mg · kg−1 · min−1
Glucose utilization rate 32.5 ± 2.8 21.5 ± 1.8* 18.6 ± 0.4 14.5 ± 1.0* 
 (mg · kg−1 · min−1
Hepatic glucose production 3.1 ± 1.8 6.1 ± 2.0* 2.1 ± 0.4 3.2 ± 0.6* 
 (mg · kg−1 · min−1
Rg′ (muscle) 14.6 ± 1.2 11.0 ± 1.6* 12.4 ± 0.4 8.7 ± 0.6* 
 (μmol · 100 g−1 · min−1
2 weeks salt loading
8 weeks salt loading
ControlsHigh salt–fed ratsControlsHigh salt–fed rats
n 
Plasma insulin (ng/dl) 325 ± 34 321 ± 35 315 ± 35 345 ± 37 
Blood glucose (mmol/l) 5.60 ± 0.34 5.53 ± 0.38 5.53 ± 0.29 5.49 ± 0.36 
Glucose infusion rate 29.4 ± 3.8 15.5 ± 5.8* 16.5 ± 0.6 11.2 ± 1.2 
 (mg · kg−1 · min−1
Glucose utilization rate 32.5 ± 2.8 21.5 ± 1.8* 18.6 ± 0.4 14.5 ± 1.0* 
 (mg · kg−1 · min−1
Hepatic glucose production 3.1 ± 1.8 6.1 ± 2.0* 2.1 ± 0.4 3.2 ± 0.6* 
 (mg · kg−1 · min−1
Rg′ (muscle) 14.6 ± 1.2 11.0 ± 1.6* 12.4 ± 0.4 8.7 ± 0.6* 
 (μmol · 100 g−1 · min−1

Data are means ± SE.

*

P < 0.05.

P < 0.01 (control versus high-salt–fed rats.

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