Kg and logarithm of acute insulin response at age 50 years and IMGU and BMI at age 70 years in Swedish men, according to genotype of the Met326Ile variant of the p85α regulatory subunit of PI3K
| Genotype . | Met326Met (n = 875) . | Met326Ile (n = 291) . | Ile326Ile (n = 24) . | P . |
|---|---|---|---|---|
| BMI at 70 years (kg/m2) | 26.3 ± 3.4 | 26.3 ± 3.4 | 25.8 ± 3.5 | 0.8 |
| (n = 868) | (n = 289) | (n = 24) | ||
| Met326Met + Met326Ile* | Met326Ile + Ile326Ile† | |||
| Kg (mmol · l−1 · min−1)‡ | 1.8 ± 0.7 | 1.8 ± 0.7 | 1.8 ± 0.7 | 0.8* |
| (n = 917) | (n = 237) | (n = 17) | 0.8† | |
| Log (acute insulin response 0–8 min)‡ | 5.0 ± 0.7 | 5.0 ± 0.7 | 5.0 ± 0.6 | 0.8* |
| (n = 942) | (n = 247) | (n = 19) | 1.0† | |
| IMGU (mg · kg–1 · min–1 · [mU/l]–1 · 100)§ | 5.0 ± 2.5 | 5.1 ± 2.5 | 5.2 ± 2.2 | 0.7* |
| (n = 1113) | (n = 299) | (n = 24) | 0.7† |
| Genotype . | Met326Met (n = 875) . | Met326Ile (n = 291) . | Ile326Ile (n = 24) . | P . |
|---|---|---|---|---|
| BMI at 70 years (kg/m2) | 26.3 ± 3.4 | 26.3 ± 3.4 | 25.8 ± 3.5 | 0.8 |
| (n = 868) | (n = 289) | (n = 24) | ||
| Met326Met + Met326Ile* | Met326Ile + Ile326Ile† | |||
| Kg (mmol · l−1 · min−1)‡ | 1.8 ± 0.7 | 1.8 ± 0.7 | 1.8 ± 0.7 | 0.8* |
| (n = 917) | (n = 237) | (n = 17) | 0.8† | |
| Log (acute insulin response 0–8 min)‡ | 5.0 ± 0.7 | 5.0 ± 0.7 | 5.0 ± 0.6 | 0.8* |
| (n = 942) | (n = 247) | (n = 19) | 1.0† | |
| IMGU (mg · kg–1 · min–1 · [mU/l]–1 · 100)§ | 5.0 ± 2.5 | 5.1 ± 2.5 | 5.2 ± 2.2 | 0.7* |
| (n = 1113) | (n = 299) | (n = 24) | 0.7† |
Data are means ± SD.
Heterozygous and wild-type carriers are analyzed together against homozygous carriers in a recessive genetic model as previously described (10,11);
homozygous and heterozygous carriers are analyzed together against wild-type carriers in a dominant/codominant model;
measured during an IVGTT (0.5 g glucose/kg body wt); P values adjusted for BMI and fasting serum insulin: P = 0.9 (recessive model) and P = 1.0 (dominant model);
measured during the last 60–120 min of steady state of a 120-min hyperinsulinemic-euglycemic clamp (56 mU insulin · min–1 · m–2).