Prevalence of type 2 diabetes and impaired glucose tolerance during a 20-year follow-up period (from age 50 to 70 years) in 1,157 Swedish men who underwent an oral glucose tolerance test, according to genotype of the Met326Ile variant of the p85α regulatory subunit of PI3K
| Genotype . | Phenotype . | Total . | ||
|---|---|---|---|---|
| Type 2 diabetes* . | Impaired glucose tolerance† . | Normal glucose tolerance . | ||
| Ile326Ile | 1 (4) | 3 (13) | 20 (83) | 24 (100) |
| Met326Ile‡ | 35 (13) | 36 (13) | 208 (74) | 279 (100) |
| Met326Met‡ | 137 (16) | 107 (13) | 610 (71) | 854 (100) |
| Genotype . | Phenotype . | Total . | ||
|---|---|---|---|---|
| Type 2 diabetes* . | Impaired glucose tolerance† . | Normal glucose tolerance . | ||
| Ile326Ile | 1 (4) | 3 (13) | 20 (83) | 24 (100) |
| Met326Ile‡ | 35 (13) | 36 (13) | 208 (74) | 279 (100) |
| Met326Met‡ | 137 (16) | 107 (13) | 610 (71) | 854 (100) |
Data are n (%).
P = 0.2 (Fischer’s exact test);
P = 0.4 (Fischer’s exact test) for type 2 diabetes or impaired glucose tolerance combined;
heterozygous and wild-type carriers are analyzed together, as previously described (10,11).