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TABLE 1

Effect of long-term high-fat feeding in wild-type and PPAR-α–null mice on two genetic backgrounds

C57BL/6N mice
Sv/129 mice
Wild-type
PPAR-α–null
Wild-type
PPAR-α–null
Standard diet (n = 6)High-fat diet (n = 6)Standard diet (n = 6)High-fat diet (n = 6)Standard diet (n = 8)High-fat diet (n = 8)Standard diet (n = 8)High-fat diet (n = 8)
Food intake (kcal · kg−1 · day−1465 ± 28.5 511 ± 15.2 506 ± 21.0 560 ± 28.9 383 ± 7.35 414 ± 13.3 369 ± 11.6 386 ± 22.4 
Body weight (g) 32.7 ± 0.95 38.0 ± 1.37 30.8 ± 0.94 32.4 ± 0.78 27.1 ± 0.80 34.5 ± 1.28 29.6 ± 0.70 33.1 ± 0.90 
Liver weight (g) 1.46 ± 0.12 1.44 ± 0.10 1.50 ± 0.07 1.48 ± 0.11 1.00 ± 0.03 1.26 ± 0.05 1.26 ± 0.08 1.95 ± 0.10 
Adiposity index* (%) 1.60 ± 0.33 3.58 ± 0.34 1.71 ± 0.25 3.74 ± 0.40 2.94 ± 0.23 6.34 ± 0.78 3.42 ± 0.36 5.93 ± 0.52 
Plasma glucose (mmol/l) 9.8 ± 0.67 11.5 ± 0.75 10.6 ± 0.72 9.3 ± 0.42 9.6 ± 0.56 11.6 ± 0.58 9.1 ± 0.41 8.2 ± 0.65 
Plasma insulin (pmol/l) 209 ± 21.3 398 ± 50.1 189 ± 31.8 225 ± 30.2 215 ± 23.9 378 ± 38.8 284 ± 26.9 256 ± 32.3 
C57BL/6N mice
Sv/129 mice
Wild-type
PPAR-α–null
Wild-type
PPAR-α–null
Standard diet (n = 6)High-fat diet (n = 6)Standard diet (n = 6)High-fat diet (n = 6)Standard diet (n = 8)High-fat diet (n = 8)Standard diet (n = 8)High-fat diet (n = 8)
Food intake (kcal · kg−1 · day−1465 ± 28.5 511 ± 15.2 506 ± 21.0 560 ± 28.9 383 ± 7.35 414 ± 13.3 369 ± 11.6 386 ± 22.4 
Body weight (g) 32.7 ± 0.95 38.0 ± 1.37 30.8 ± 0.94 32.4 ± 0.78 27.1 ± 0.80 34.5 ± 1.28 29.6 ± 0.70 33.1 ± 0.90 
Liver weight (g) 1.46 ± 0.12 1.44 ± 0.10 1.50 ± 0.07 1.48 ± 0.11 1.00 ± 0.03 1.26 ± 0.05 1.26 ± 0.08 1.95 ± 0.10 
Adiposity index* (%) 1.60 ± 0.33 3.58 ± 0.34 1.71 ± 0.25 3.74 ± 0.40 2.94 ± 0.23 6.34 ± 0.78 3.42 ± 0.36 5.93 ± 0.52 
Plasma glucose (mmol/l) 9.8 ± 0.67 11.5 ± 0.75 10.6 ± 0.72 9.3 ± 0.42 9.6 ± 0.56 11.6 ± 0.58 9.1 ± 0.41 8.2 ± 0.65 
Plasma insulin (pmol/l) 209 ± 21.3 398 ± 50.1 189 ± 31.8 225 ± 30.2 215 ± 23.9 378 ± 38.8 284 ± 26.9 256 ± 32.3 

Data are means ± SE. Mice on the C 57BL/6N genetic background were fed the high-fat diet for 16 weeks. Mice on the Sv/129 genetic background were fed the high-fat diet for 22 weeks.

*

Adiposity index was the ratio of epididymal adipose tissue to body weight for C57BL/6N mice and the ratio of epididymal + inguinal adipose tissue to body weight for Sv/129 mice.

P < 0.05 versus standard diet.

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