American Diabetes Association

TABLE 2

Effect of high-fat feeding on IR index

	Wild-type		PPAR-α–null
	Standard diet (n = 5)	High-fat diet (n = 5)	Standard diet (n = 6)	High-fat diet (n = 5)
AUC glucose (mg/dl · 2 h)	115 ± 15	296 ± 78^*	106 ± 16	128 ± 27
AUC insulin (ng/dl · 2 h)	17.3 ± 3.1	27.6 ± 2.7^*	23.2 ± 6.3	12.8 ± 2.5
IR Index (AUC glucose · AUC insulin)	1,970 ± 413	8,400 ± 2,790^*	2,490 ± 730	1,680 ± 548

	Wild-type		PPAR-α–null
	Standard diet (n = 5)	High-fat diet (n = 5)	Standard diet (n = 6)	High-fat diet (n = 5)
AUC glucose (mg/dl · 2 h)	115 ± 15	296 ± 78^*	106 ± 16	128 ± 27
AUC insulin (ng/dl · 2 h)	17.3 ± 3.1	27.6 ± 2.7^*	23.2 ± 6.3	12.8 ± 2.5
IR Index (AUC glucose · AUC insulin)	1,970 ± 413	8,400 ± 2,790^*	2,490 ± 730	1,680 ± 548

Data are means ± SE. Areas under the insulin and glucose curves were calculated from the data shown in Fig. 4. The IR index is the product of glucose and insulin AUCs.

P < 0.05 versus standard diet.

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