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TABLE 2

Effect of high-fat feeding on IR index

Wild-type
PPAR-α–null
Standard diet (n = 5)High-fat diet (n = 5)Standard diet (n = 6)High-fat diet (n = 5)
AUC glucose (mg/dl · 2 h) 115 ± 15 296 ± 78* 106 ± 16 128 ± 27 
AUC insulin (ng/dl · 2 h) 17.3 ± 3.1 27.6 ± 2.7* 23.2 ± 6.3 12.8 ± 2.5 
IR Index (AUC glucose · AUC insulin) 1,970 ± 413 8,400 ± 2,790* 2,490 ± 730 1,680 ± 548 
Wild-type
PPAR-α–null
Standard diet (n = 5)High-fat diet (n = 5)Standard diet (n = 6)High-fat diet (n = 5)
AUC glucose (mg/dl · 2 h) 115 ± 15 296 ± 78* 106 ± 16 128 ± 27 
AUC insulin (ng/dl · 2 h) 17.3 ± 3.1 27.6 ± 2.7* 23.2 ± 6.3 12.8 ± 2.5 
IR Index (AUC glucose · AUC insulin) 1,970 ± 413 8,400 ± 2,790* 2,490 ± 730 1,680 ± 548 

Data are means ± SE. Areas under the insulin and glucose curves were calculated from the data shown in Fig. 4. The IR index is the product of glucose and insulin AUCs.

*

P < 0.05 versus standard diet.

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