Reproductive effects of ALX-induced (100 mg/kg, intravenous) maternal diabetes in C57BL/6J mice with and without the Sp allele
| Genotype mated* . | Treatment . | Number of litters . | Plasma glucose† . | Implants per litter ± SD . | Mean fetal weight ± SD . | % Resorbed . |
|---|---|---|---|---|---|---|
| +/+ × +/+ | Control‡ | 12 | 173 ± 12 | 8.3 ± 2.05 | 1.05 ± 0.10 | 11.1 |
| +/+ × Sp/+ | Control | 10 | 179 ± 5 | 8.3 ± 1.57 | 1.09 ± 0.12 | 13.3 |
| Sp/+ × +/+ | Control | 17 | 173 ± 8§ | 8.4 ± 1.00 | 1.13 ± 0.07 | 12.7 |
| +/+ × +/+ | ALX | 17 | 677 ± 139∥ | 6.8 ± 2.22 | 0.69 ± 0.18∥ | 35.7 |
| +/+ × Sp/+ | ALX | 38 | 704 ± 177∥ | 7.3 ± 2.36 | 0.76 ± 0.23∥¶ | 38.4∥ |
| Sp/+ × +/+ | ALX | 19 | 678 ± 141∥ | 7.0 ± 2.09∥ | 0.73 ± 0.18∥ | 49.3∥ |
| Genotype mated* . | Treatment . | Number of litters . | Plasma glucose† . | Implants per litter ± SD . | Mean fetal weight ± SD . | % Resorbed . |
|---|---|---|---|---|---|---|
| +/+ × +/+ | Control‡ | 12 | 173 ± 12 | 8.3 ± 2.05 | 1.05 ± 0.10 | 11.1 |
| +/+ × Sp/+ | Control | 10 | 179 ± 5 | 8.3 ± 1.57 | 1.09 ± 0.12 | 13.3 |
| Sp/+ × +/+ | Control | 17 | 173 ± 8§ | 8.4 ± 1.00 | 1.13 ± 0.07 | 12.7 |
| +/+ × +/+ | ALX | 17 | 677 ± 139∥ | 6.8 ± 2.22 | 0.69 ± 0.18∥ | 35.7 |
| +/+ × Sp/+ | ALX | 38 | 704 ± 177∥ | 7.3 ± 2.36 | 0.76 ± 0.23∥¶ | 38.4∥ |
| Sp/+ × +/+ | ALX | 19 | 678 ± 141∥ | 7.0 ± 2.09∥ | 0.73 ± 0.18∥ | 49.3∥ |
Female genotype listed first;
plasma glucose levels (mg/dl) obtained on day 18 of gestation;
+/+ × +/+ control animals treated with water (10 μl/g) on day 8 of gestation;
determined in four dams;
significantly different than the same-genotype control (P ≤ 0.05);
fetal weight determined in 33 +/+ × Sp/+ litters.