Triglyceride content of islet β-cells and non–β-cells after 48 h of culture
| Addition . | Cellular triglyceride content (pg/ng DNA) . | |
|---|---|---|
| β-Cells . | Non–β-Cells . | |
| Control | 162 ± 30 | 173 ± 50 |
| 0.25 mmol/l oleate | 652 ± 82* | 258 ± 24† |
| 0.25 mmol/l palmitate | 389 ± 38* | 259 ± 51 |
| 0.125 mmol/l oleate | 686 ± 135‡ | 261 ± 106 |
| 0.125 mmol/l palmitate | ||
| 0.25 mmol/l bromopalmitate | 251 ± 112 | 235 ± 115 |
| Addition . | Cellular triglyceride content (pg/ng DNA) . | |
|---|---|---|
| β-Cells . | Non–β-Cells . | |
| Control | 162 ± 30 | 173 ± 50 |
| 0.25 mmol/l oleate | 652 ± 82* | 258 ± 24† |
| 0.25 mmol/l palmitate | 389 ± 38* | 259 ± 51 |
| 0.125 mmol/l oleate | 686 ± 135‡ | 261 ± 106 |
| 0.125 mmol/l palmitate | ||
| 0.25 mmol/l bromopalmitate | 251 ± 112 | 235 ± 115 |
Data are means ± SE for five β-cell and six (non–β-cell) independent experiments. Statistical significance of differences between FFA condition and control was calculated by analysis of variance, followed by paired t test with the Bonferroni correction:
P < 0.005,
P < 0.05. Statistical significance of differences between islet β-cells and islet endocrine non–β-cells for identical conditions was calculated by analysis of variance, followed by unpaired t test with the Bonferroni correction:
P < 0.001.