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TABLE 3

Genotypes and minor allele frequencies in diallelic polymorphisms, according to the absence or presence of nephropathy

GenePolymorphismAbsence of nephropathy (n = 193)
Presence of nephropathy (n = 199)
P
Genotype frequency*
Rare allele frequencyGenotype frequency*
Rare allele frequency
111222111222
RAGE 
 C-1152A 84.7 15.3 0.0 0.076 91.5 8.5 0.0 0.043 0.043 
 T-388A 48.7 42.2 9.1 0.302 43.6 44.6 11.8 0.341 0.52 
 G82S 90.6 9.4 0.0 0.047 93.6 5.9 0.5 0.035 0.27 
AGE-R1 
 G120G 35.1 49.2 15.7 0.403 38.1 49.2 12.7 0.373 0.65 
 C+17/in4T 66.3 30.0 3.7 0.187 62.7 33.2 4.1 0.207 0.77 
 T-16/in6C 33.0 53.2 13.8 0.404 35.1 47.9 17.0 0.410 0.53 
 +32/in8/ins/del 78.7 20.3 1.0 0.112 72.9 23.5 3.6 0.153 0.17 
 G+40A 79.2 18.2 2.6 0.117 78.0 20.5 1.5 0.118 0.67 
AGE-R3 
 T98P 31.9 53.4 14.7 0.414 30.3 52.3 17.4 0.436 0.75 
GenePolymorphismAbsence of nephropathy (n = 193)
Presence of nephropathy (n = 199)
P
Genotype frequency*
Rare allele frequencyGenotype frequency*
Rare allele frequency
111222111222
RAGE 
 C-1152A 84.7 15.3 0.0 0.076 91.5 8.5 0.0 0.043 0.043 
 T-388A 48.7 42.2 9.1 0.302 43.6 44.6 11.8 0.341 0.52 
 G82S 90.6 9.4 0.0 0.047 93.6 5.9 0.5 0.035 0.27 
AGE-R1 
 G120G 35.1 49.2 15.7 0.403 38.1 49.2 12.7 0.373 0.65 
 C+17/in4T 66.3 30.0 3.7 0.187 62.7 33.2 4.1 0.207 0.77 
 T-16/in6C 33.0 53.2 13.8 0.404 35.1 47.9 17.0 0.410 0.53 
 +32/in8/ins/del 78.7 20.3 1.0 0.112 72.9 23.5 3.6 0.153 0.17 
 G+40A 79.2 18.2 2.6 0.117 78.0 20.5 1.5 0.118 0.67 
AGE-R3 
 T98P 31.9 53.4 14.7 0.414 30.3 52.3 17.4 0.436 0.75 

Odds ratio (95% CI) for nephropathy associated with RAGE/A-1152 carrying 0.49 (0.25–0.94); P = 0.031. RAGE/A2A: rare allele carriers, 5 subjects without and 6 subjects with nephropathy.

*

The major allele is coded 1, and the minor allele is coded 2;

difference in genotype frequency between absence versus presence of nephropathy (2 df).

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