Genotypes and minor allele frequencies in diallelic polymorphisms, according to the absence or presence of nephropathy
| Gene . | Polymorphism . | Absence of nephropathy (n = 193) . | Presence of nephropathy (n = 199) . | P† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequency* . | Rare allele frequency . | Genotype frequency* . | Rare allele frequency . | |||||||
| 11 . | 12 . | 22 . | 11 . | 12 . | 22 . | |||||
| RAGE | ||||||||||
| C-1152A | 84.7 | 15.3 | 0.0 | 0.076 | 91.5 | 8.5 | 0.0 | 0.043 | 0.043 | |
| T-388A | 48.7 | 42.2 | 9.1 | 0.302 | 43.6 | 44.6 | 11.8 | 0.341 | 0.52 | |
| G82S | 90.6 | 9.4 | 0.0 | 0.047 | 93.6 | 5.9 | 0.5 | 0.035 | 0.27 | |
| AGE-R1 | ||||||||||
| G120G | 35.1 | 49.2 | 15.7 | 0.403 | 38.1 | 49.2 | 12.7 | 0.373 | 0.65 | |
| C+17/in4T | 66.3 | 30.0 | 3.7 | 0.187 | 62.7 | 33.2 | 4.1 | 0.207 | 0.77 | |
| T-16/in6C | 33.0 | 53.2 | 13.8 | 0.404 | 35.1 | 47.9 | 17.0 | 0.410 | 0.53 | |
| +32/in8/ins/del | 78.7 | 20.3 | 1.0 | 0.112 | 72.9 | 23.5 | 3.6 | 0.153 | 0.17 | |
| G+40A | 79.2 | 18.2 | 2.6 | 0.117 | 78.0 | 20.5 | 1.5 | 0.118 | 0.67 | |
| AGE-R3 | ||||||||||
| T98P | 31.9 | 53.4 | 14.7 | 0.414 | 30.3 | 52.3 | 17.4 | 0.436 | 0.75 | |
| Gene . | Polymorphism . | Absence of nephropathy (n = 193) . | Presence of nephropathy (n = 199) . | P† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequency* . | Rare allele frequency . | Genotype frequency* . | Rare allele frequency . | |||||||
| 11 . | 12 . | 22 . | 11 . | 12 . | 22 . | |||||
| RAGE | ||||||||||
| C-1152A | 84.7 | 15.3 | 0.0 | 0.076 | 91.5 | 8.5 | 0.0 | 0.043 | 0.043 | |
| T-388A | 48.7 | 42.2 | 9.1 | 0.302 | 43.6 | 44.6 | 11.8 | 0.341 | 0.52 | |
| G82S | 90.6 | 9.4 | 0.0 | 0.047 | 93.6 | 5.9 | 0.5 | 0.035 | 0.27 | |
| AGE-R1 | ||||||||||
| G120G | 35.1 | 49.2 | 15.7 | 0.403 | 38.1 | 49.2 | 12.7 | 0.373 | 0.65 | |
| C+17/in4T | 66.3 | 30.0 | 3.7 | 0.187 | 62.7 | 33.2 | 4.1 | 0.207 | 0.77 | |
| T-16/in6C | 33.0 | 53.2 | 13.8 | 0.404 | 35.1 | 47.9 | 17.0 | 0.410 | 0.53 | |
| +32/in8/ins/del | 78.7 | 20.3 | 1.0 | 0.112 | 72.9 | 23.5 | 3.6 | 0.153 | 0.17 | |
| G+40A | 79.2 | 18.2 | 2.6 | 0.117 | 78.0 | 20.5 | 1.5 | 0.118 | 0.67 | |
| AGE-R3 | ||||||||||
| T98P | 31.9 | 53.4 | 14.7 | 0.414 | 30.3 | 52.3 | 17.4 | 0.436 | 0.75 | |
Odds ratio (95% CI) for nephropathy associated with RAGE/A-1152 carrying 0.49 (0.25–0.94); P = 0.031. RAGE/A2A: rare allele carriers, 5 subjects without and 6 subjects with nephropathy.
The major allele is coded 1, and the minor allele is coded 2;
difference in genotype frequency between absence versus presence of nephropathy (2 df).