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TABLE 1

Arterial plasma levels of norepinephrine, epinephrine, and cortisol before and after oral administration of BAY R 3401 in the presence of non-insulin-induced hypoglycemia with and without mild hyperinsulinemia and in the presence of euglycemia with and without mild hyperinsulinemia in 18-h-fasted conscious dogs

GroupControl periodBAY R 3401 with or without peripheral glucose and/or insulin infusion (min)
1020306090120180
Hypoglycemia         
 Norepinephrine (pmol/l) 981 ± 177 993 ± 171 898 ± 171 1,069 ± 136 1,011 ± 100 969 ± 124 1,046 ± 130 1,099 ± 254 
 Epinephrine (pmol/l) 426 ± 60 513 ± 98 437 ± 98 475 ± 71 458 ± 87 458 ± 60 431 ± 82 453 ± 93 
 Cortisol (nmol/l) 41 ± 8 50 ± 11 55 ± 11 58 ± 17 50 ± 8 47 ± 8 63 ± 19 66 ± 33 
Hypoglycemia + insulin         
 Norepinephrine (pmol/l) 1,454 ± 242 1,188 ± 272 1,336 ± 272 1,543 ± 272 1,714 ± 313 1,720 ± 266 1,667 ± 219 1,856 ± 242 
 Epinephrine (pmol/l) 758 ± 147 519 ± 98 415 ± 98 770 ± 153 857 ± 153 830 ± 158 961 ± 104 1,037 ± 191 
 Cortisol (nmol/l) 50 ± 14 52 ± 11 50 ± 11 74 ± 19 88 ± 22 99 ± 19* 99 ± 19* 74 ± 14 
Euglycemia         
 Norepinephrine (pmol/l) 881 ± 207 946 ± 154 934 ± 154 786 ± 183 798 ± 154 893 ± 201 822 ± 195 851 ± 177 
 Epinephrine (pmol/l) 420 ± 180 409 ± 87 284 ± 87 295 ± 115 273 ± 33 272 ± 175 218 ± 104 442 ± 196 
 Cortisol (nmol/l) 58 ± 14 61 ± 14 58 ± 14 55 ± 22 36 ± 6 47 ± 8 55 ± 14 74 ± 36 
Euglycemia + insulin         
 Norepinephrine (pmol/l) 940 ± 100 916 ± 89 1011 ± 136 958 ± 106 1058 ± 166 916 ± 112 1023 ± 142 1383 ± 148 
 Epinephrine (pmol/l) 524 ± 136 551 ± 142 579 ± 158 579 ± 175 633 ± 186 464 ± 109 475 ± 164 628 ± 218 
 Cortisol (nmol/l) 58 ± 11 66 ± 8 63 ± 8 94 ± 14* 91 ± 11* 77 ± 3 88 ± 27 110 ± 19* 
GroupControl periodBAY R 3401 with or without peripheral glucose and/or insulin infusion (min)
1020306090120180
Hypoglycemia         
 Norepinephrine (pmol/l) 981 ± 177 993 ± 171 898 ± 171 1,069 ± 136 1,011 ± 100 969 ± 124 1,046 ± 130 1,099 ± 254 
 Epinephrine (pmol/l) 426 ± 60 513 ± 98 437 ± 98 475 ± 71 458 ± 87 458 ± 60 431 ± 82 453 ± 93 
 Cortisol (nmol/l) 41 ± 8 50 ± 11 55 ± 11 58 ± 17 50 ± 8 47 ± 8 63 ± 19 66 ± 33 
Hypoglycemia + insulin         
 Norepinephrine (pmol/l) 1,454 ± 242 1,188 ± 272 1,336 ± 272 1,543 ± 272 1,714 ± 313 1,720 ± 266 1,667 ± 219 1,856 ± 242 
 Epinephrine (pmol/l) 758 ± 147 519 ± 98 415 ± 98 770 ± 153 857 ± 153 830 ± 158 961 ± 104 1,037 ± 191 
 Cortisol (nmol/l) 50 ± 14 52 ± 11 50 ± 11 74 ± 19 88 ± 22 99 ± 19* 99 ± 19* 74 ± 14 
Euglycemia         
 Norepinephrine (pmol/l) 881 ± 207 946 ± 154 934 ± 154 786 ± 183 798 ± 154 893 ± 201 822 ± 195 851 ± 177 
 Epinephrine (pmol/l) 420 ± 180 409 ± 87 284 ± 87 295 ± 115 273 ± 33 272 ± 175 218 ± 104 442 ± 196 
 Cortisol (nmol/l) 58 ± 14 61 ± 14 58 ± 14 55 ± 22 36 ± 6 47 ± 8 55 ± 14 74 ± 36 
Euglycemia + insulin         
 Norepinephrine (pmol/l) 940 ± 100 916 ± 89 1011 ± 136 958 ± 106 1058 ± 166 916 ± 112 1023 ± 142 1383 ± 148 
 Epinephrine (pmol/l) 524 ± 136 551 ± 142 579 ± 158 579 ± 175 633 ± 186 464 ± 109 475 ± 164 628 ± 218 
 Cortisol (nmol/l) 58 ± 11 66 ± 8 63 ± 8 94 ± 14* 91 ± 11* 77 ± 3 88 ± 27 110 ± 19* 

Data for each group are means ± SE from five dogs.

*

Significantly changed from the values during the control period in the same group.

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