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TABLE 1

Allele frequencies (number of alleles) of the variants observed in the IRS-2 gene in Chinese and Finnish patients with type 2 diabetes or in the respective control subjects

NucleotideCodonNucleotide changeAmino acid changeChinese patients
Finnish patients
Control subjects (n = 85)Type 2 diabetic patients (n = 100)Control subjects (n = 82)Type 2 diabetic patients (n = 85)
85 29 Insertion AAC Asn8→Asn9 0.015 (3) 0.006 (1) 
441 147 CGC→CGG — ND 0.005 (1)* ND 0* 
465 155 CCC→CCG — ND 0.005 (1)* ND 0* 
468 156 GCC→GCT — ND 0.005 (1)* ND 0* 
469 157 GCC→ACC Ala→Thr0  0.005 (1) 
1939 647 CTG→GTG Leu→Val 0.006 (1) 
2169 723 AGT→AGC — ND 0.560 (112)* ND 0.359 (61)* 
2448 816 TGT→TGC — ND 0.450 (90)* ND 0.641 (109)* 
2487 829 CCC→CCT — ND 0.450 (90)* ND 0.512 (87)* 
3170 1057 GGC→GAC Gly→Asp 0.300 0.350 (70) 0.305 (50) 0.312 (53) 
NucleotideCodonNucleotide changeAmino acid changeChinese patients
Finnish patients
Control subjects (n = 85)Type 2 diabetic patients (n = 100)Control subjects (n = 82)Type 2 diabetic patients (n = 85)
85 29 Insertion AAC Asn8→Asn9 0.015 (3) 0.006 (1) 
441 147 CGC→CGG — ND 0.005 (1)* ND 0* 
465 155 CCC→CCG — ND 0.005 (1)* ND 0* 
468 156 GCC→GCT — ND 0.005 (1)* ND 0* 
469 157 GCC→ACC Ala→Thr0  0.005 (1) 
1939 647 CTG→GTG Leu→Val 0.006 (1) 
2169 723 AGT→AGC — ND 0.560 (112)* ND 0.359 (61)* 
2448 816 TGT→TGC — ND 0.450 (90)* ND 0.641 (109)* 
2487 829 CCC→CCT — ND 0.450 (90)* ND 0.512 (87)* 
3170 1057 GGC→GAC Gly→Asp 0.300 0.350 (70) 0.305 (50) 0.312 (53) 
*

Determinated in 40 subjects with type 2 diabetes. ND, not determined.

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