Skip to Main Content
TABLE 3

TDT analysis of IL4R haplotypes

Haplotype IDHaplotypeAll families
Either/both sib DR3/4
Neither sib DR3/4
Number of informative transmission events% transmittedOR95% CINumber of informative transmission events% transmittedOR95% CINumber of informative transmission events% transmittedOR95% CI
H-1 11111111 550 52% 1.09 0.92–1.30 269 52% 1.08 0.85–1.38 281 53% 1.11 0.86–1.40 
H-2 21111111 498 51% 1.06 0.90–1.25 226 50% 1.01 0.80–1.28 272 52% 1.10 0.86–1.42 
H-3 21222221 122 39%* 0.63 0.44–0.89 61 44% 0.80 0.50–1.27 62 33% 0.49 0.28–0.81 
H-4 22111111 93 47% 0.89 0.61–1.30 50 45% 0.81 0.47–1.36 43 50% 0.99 0.56–1.71 
H-5 11222221 86 49% 0.95 0.59–1.50 37 40% 0.68 0.30–1.42 49 55% 1.24 0.67–2.36 
H-6 22111221 77 44% 0.78 0.45–1.24 27 52% 1.07 0.49–2.40 50 40% 0.65 0.31–1.23 
H-7 11111121 77 57% 1.33 0.90–2.06 43 55% 1.23 0.71–2.20 33 60% 1.48 0.75–3.19 
H-8 21111121 27 43% 0.75 0.38–1.60 12 38% 0.61 0.18–2.22 15 47% 0.88 0.38–3.09 
H-9 22111222 16 45% 0.83 0.25–2.68 10 50% 1.00 —‡ 38% 0.60  
Haplotype IDHaplotypeAll families
Either/both sib DR3/4
Neither sib DR3/4
Number of informative transmission events% transmittedOR95% CINumber of informative transmission events% transmittedOR95% CINumber of informative transmission events% transmittedOR95% CI
H-1 11111111 550 52% 1.09 0.92–1.30 269 52% 1.08 0.85–1.38 281 53% 1.11 0.86–1.40 
H-2 21111111 498 51% 1.06 0.90–1.25 226 50% 1.01 0.80–1.28 272 52% 1.10 0.86–1.42 
H-3 21222221 122 39%* 0.63 0.44–0.89 61 44% 0.80 0.50–1.27 62 33% 0.49 0.28–0.81 
H-4 22111111 93 47% 0.89 0.61–1.30 50 45% 0.81 0.47–1.36 43 50% 0.99 0.56–1.71 
H-5 11222221 86 49% 0.95 0.59–1.50 37 40% 0.68 0.30–1.42 49 55% 1.24 0.67–2.36 
H-6 22111221 77 44% 0.78 0.45–1.24 27 52% 1.07 0.49–2.40 50 40% 0.65 0.31–1.23 
H-7 11111121 77 57% 1.33 0.90–2.06 43 55% 1.23 0.71–2.20 33 60% 1.48 0.75–3.19 
H-8 21111121 27 43% 0.75 0.38–1.60 12 38% 0.61 0.18–2.22 15 47% 0.88 0.38–3.09 
H-9 22111222 16 45% 0.83 0.25–2.68 10 50% 1.00 —‡ 38% 0.60  

Each haplotype is listed by the ordered set of alleles present at each of the eight IL4R SNPs. A “1” denotes the presence of the reference allele, and a “2” indicates the presence of the variant allele for each SNP, as described in Table 1. Haplotypes are also given arbitrary haplotype ID numbers (H-1 through -9). The table shows only haplotypes that were observed in at least 15 effective transmission events in the affected children (representing 1,546/1,658 = 93% of observed haplotypes in informative transmission events). For each haplotype, percent transmitted is the ratio of actual transmissions to possible transmissions to affected children of informative parents. The ORs compare actual with Mendelian segregation ratios. The 95% CI column lists the upper and lower bounds of the 95% CI of the OR, calculated based on the number of families (not shown) informative for that haplotype. P values are based on permutation.

*

Significant after adjustment at P = 0.021;

significant after adjustment at P = 0.015;

CIs are not reported in instances where 10 or fewer families were informative for the haplotype.

Close Modal

or Create an Account

Close Modal
Close Modal