Physical and biochemical parameters of nondiabetic and STZ diabetic (mRen-2)27 rats treated with either ALT-946 or AG
| Ren-2 rats . | n . | Body weight (g) . | Kidney weight (g) . | SBP (mmHg) . | GFR (ml/min) . |
|---|---|---|---|---|---|
| Nondiabetic | 8 | 319 ± 10.8 | 1.00 ± 0.05 | 188 ± 5 | 2.5 ± 0.2 |
| Diabetic | 7 | 230 ± 27* | 1.37 ± 0.05* | 187 ± 4 | 3.3 ± 0.2† |
| Nondiabetic + ALT-946 | 8 | 293 ± 5 | 0.98 ± 0.04 | 195 ± 6 | 2.3 ± 0.3 |
| Diabetic + ALT-946 | 8 | 258 ± 6†‡ | 1.56 ± 0.05† | 194 ± 8 | 3.4 ± 0.3† |
| Nondiabetic + AG | 7 | 290 ± 5.6 | 0.98 ± 0.04 | 184 ± 5 | 2.1 ± 0.4 |
| Diabetic + AG | 8 | 205 ± 8* | 1.49 ± 0.05† | 203 ± 4 | 3.5 ± 0.4† |
| Ren-2 rats . | n . | Body weight (g) . | Kidney weight (g) . | SBP (mmHg) . | GFR (ml/min) . |
|---|---|---|---|---|---|
| Nondiabetic | 8 | 319 ± 10.8 | 1.00 ± 0.05 | 188 ± 5 | 2.5 ± 0.2 |
| Diabetic | 7 | 230 ± 27* | 1.37 ± 0.05* | 187 ± 4 | 3.3 ± 0.2† |
| Nondiabetic + ALT-946 | 8 | 293 ± 5 | 0.98 ± 0.04 | 195 ± 6 | 2.3 ± 0.3 |
| Diabetic + ALT-946 | 8 | 258 ± 6†‡ | 1.56 ± 0.05† | 194 ± 8 | 3.4 ± 0.3† |
| Nondiabetic + AG | 7 | 290 ± 5.6 | 0.98 ± 0.04 | 184 ± 5 | 2.1 ± 0.4 |
| Diabetic + AG | 8 | 205 ± 8* | 1.49 ± 0.05† | 203 ± 4 | 3.5 ± 0.4† |
Values are expressed as mean ± SE.
P < 0.01 compared with respective nondiabetic group;
P < 0.05 compared with respective nondiabetic group;
P < 0.01 compared with diabetic + AG.