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TABLE 2

Genotypic distribution for KCNJ10 polymorphism and odds ratio (OR) with 95% CI for diabetes in participants in the case-control study and genome-wide linkage studies

StatusGenotype
Dominant model
Recessive model
Additive model
Overall P
111222OR (95 % CI)POR (95 % CI)POR (95 % CI)P
All participants in case-control study            
SNP1 Nondiabetic 71 (53) 51 (38) 13 (10)        
 Diabetic 65 (44) 60 (41) 22 (15) 0.61 (0.29–1.26) 0.207 0.72 (0.45–1.14) 0.190 0.75 (0.53–1.05) 0.097 0.263 
SNP3 Nondiabetic 134 (93) 10 (7) 0 (0) — —      
 Diabetic 135 (91) 13 (9) 0 (0) — — 0.78 (0.33–1.82) 0.666 0.77 (0.38–1.83) 0.561 0.666 
SNP4 Nondiabetic 113 (79) 26 (18) 4 (3) — —      
 Diabetic 115 (79) 27 (18) 3 (2) 1.36 (0.30–6.21) 0.722 1.02 (0.58–1.80) 1.000 1.05 (0.64–1.70) 0.856 0.967 
SNP5 Nondiabetic 58 (40) 59 (41) 27 (19)        
 Diabetic 60 (40) 73 (49) 17 (11) 1.81 (0.94–3.48) 0.101 0.99 (0.62–1.57) 1.000 1.16 (0.83–1.61) 0.381 0.163 
SNP8 Nondiabetic 74 (52) 56 (39) 12 (8)        
 Diabetic 83 (56) 57 (39) 8 (5) 1.62 (0.64–4.08) 0.358 1.17 (0.74–1.86) 0.556 1.20 (0.83–1.74) 0.338 0.563 
Participants in case-control study and in genome-wide linkage study            
SNP1 Nondiabetic 23 (55) 17 (41) 2 (5)        
 Diabetic 17 (35) 24 (50) 8 (16) 0.26 (0.05–1.28) 0.100 0.44 (0.19–1.02) 0.061 0.47 (0.24–0.92) 0.027 0.088 
SNP3 Nondiabetic 39 (89) 5 (11) 0 (0) — —      
 Diabetic 45 (90) 5 (10) 0 (0) — — 1.15 (0.31–4.29) 1.000 1.15 (0.31–4.28) 0.831 1.000 
SNP4 Nondiabetic 35 (80) 9 (20) 0 (0) — —      
 Diabetic 35 (71) 12 (25) 2 (4) — — 0.64 (0.25–1.68) 0.472 0.59 (0.25–1.41) 0.236 0.500 
SNP5 Nondiabetic 15 (34) 18 (41) 11 (25)        
 Diabetic 20 (40) 27 (54) 3 (6) 5.22 (1.35–20.2) 0.018 1.29 (0.56–2.99) 0.670 1.71 (0.98–3.15) 0.083 0.035 
SNP8 Nondiabetic 21 (48) 19 (43) 4 (9)        
 Diabetic 29 (60) 18 (38) 1 (2) 4.70 (0.5–43.8) 0.189 1.67 (0.73–3.82) 0.295 1.75 (0.87–3.53) 0.119 0.242 
All participants in genome-wide linkage study            
SNP1 Nondiabetic 216 (50) 182 (42) 35 (8)        
 Diabetic 250 (40) 296 (48) 76 (12) 0.62 (0.39–0.99) 0.043 0.75 (0.55–1.02) 0.071 0.76 (0.64–0.95) 0.018 0.048 
SNP5 Nondiabetic 169 (40) 195 (47) 55 (13)        
 Diabetic 226 (37) 296 (49) 86 (14) 1.05 (0.66–1.67) 0.842 0.88 (0.65–1.20) 0.436 0.95 (0.75–1.20) 0.669 0.663 
StatusGenotype
Dominant model
Recessive model
Additive model
Overall P
111222OR (95 % CI)POR (95 % CI)POR (95 % CI)P
All participants in case-control study            
SNP1 Nondiabetic 71 (53) 51 (38) 13 (10)        
 Diabetic 65 (44) 60 (41) 22 (15) 0.61 (0.29–1.26) 0.207 0.72 (0.45–1.14) 0.190 0.75 (0.53–1.05) 0.097 0.263 
SNP3 Nondiabetic 134 (93) 10 (7) 0 (0) — —      
 Diabetic 135 (91) 13 (9) 0 (0) — — 0.78 (0.33–1.82) 0.666 0.77 (0.38–1.83) 0.561 0.666 
SNP4 Nondiabetic 113 (79) 26 (18) 4 (3) — —      
 Diabetic 115 (79) 27 (18) 3 (2) 1.36 (0.30–6.21) 0.722 1.02 (0.58–1.80) 1.000 1.05 (0.64–1.70) 0.856 0.967 
SNP5 Nondiabetic 58 (40) 59 (41) 27 (19)        
 Diabetic 60 (40) 73 (49) 17 (11) 1.81 (0.94–3.48) 0.101 0.99 (0.62–1.57) 1.000 1.16 (0.83–1.61) 0.381 0.163 
SNP8 Nondiabetic 74 (52) 56 (39) 12 (8)        
 Diabetic 83 (56) 57 (39) 8 (5) 1.62 (0.64–4.08) 0.358 1.17 (0.74–1.86) 0.556 1.20 (0.83–1.74) 0.338 0.563 
Participants in case-control study and in genome-wide linkage study            
SNP1 Nondiabetic 23 (55) 17 (41) 2 (5)        
 Diabetic 17 (35) 24 (50) 8 (16) 0.26 (0.05–1.28) 0.100 0.44 (0.19–1.02) 0.061 0.47 (0.24–0.92) 0.027 0.088 
SNP3 Nondiabetic 39 (89) 5 (11) 0 (0) — —      
 Diabetic 45 (90) 5 (10) 0 (0) — — 1.15 (0.31–4.29) 1.000 1.15 (0.31–4.28) 0.831 1.000 
SNP4 Nondiabetic 35 (80) 9 (20) 0 (0) — —      
 Diabetic 35 (71) 12 (25) 2 (4) — — 0.64 (0.25–1.68) 0.472 0.59 (0.25–1.41) 0.236 0.500 
SNP5 Nondiabetic 15 (34) 18 (41) 11 (25)        
 Diabetic 20 (40) 27 (54) 3 (6) 5.22 (1.35–20.2) 0.018 1.29 (0.56–2.99) 0.670 1.71 (0.98–3.15) 0.083 0.035 
SNP8 Nondiabetic 21 (48) 19 (43) 4 (9)        
 Diabetic 29 (60) 18 (38) 1 (2) 4.70 (0.5–43.8) 0.189 1.67 (0.73–3.82) 0.295 1.75 (0.87–3.53) 0.119 0.242 
All participants in genome-wide linkage study            
SNP1 Nondiabetic 216 (50) 182 (42) 35 (8)        
 Diabetic 250 (40) 296 (48) 76 (12) 0.62 (0.39–0.99) 0.043 0.75 (0.55–1.02) 0.071 0.76 (0.64–0.95) 0.018 0.048 
SNP5 Nondiabetic 169 (40) 195 (47) 55 (13)        
 Diabetic 226 (37) 296 (49) 86 (14) 1.05 (0.66–1.67) 0.842 0.88 (0.65–1.20) 0.436 0.95 (0.75–1.20) 0.669 0.663 

Data are n (%) unless otherwise indicated. For all SNPs the more common allele is coded as “1” and the less common allele is coded as “2.” For the “dominant” model ORs are calculated comparing those homozygous or heterozygous for the common allele (11 or 12) with the odds for those homozygous for the less common allele (22). Similarly, the “recessive” model compares those homozygous for the common allele (11) with the others (12 or 22). In the additive model, the OR is calculated for each copy of the common allele. In the case-control study, P values are calculated by Fisher’s exact test, except for the additive model, for which the P value is calculated by the χ2 test. For the subjects in the genome-wide linkage study, the ORs and P values are calculated by generalized estimating equations that adjust for age, sex, birth year, and ethnicity and that account for family membership (sibship). The dominant model is not analyzed in instances where there are too few individuals homozygous for the rare allele to obtain reliable estimates. The genotypes are presented as total numbers and their percent in parenthesis.

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