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TABLE 2

Indexes of insulin secretion and insulin sensitivity in subjects with normal glucose tolerance (NGT) and IGT

NGT
IGT
AllFHFH+AllFHFH+
Insulin secretion       
    First-phase (pmol/l) 711 (651–777) 796 (718–883) 647 (562–745)* 467 (398–548) 449 (359–562) 480 (378–609)§ 
    Second-phase (pmol/l) 281 (261–304) 301 (272–334) 266 (239–297)| 203 (178–233) 209 (176–249) 199 (160–248)§ 
Insulin sensitivity (μmol · kg LBM−1 · min−1 · pmol−1 · l−10.236 ± 0.008 0.228 ± 0.011 0.242 ± 0.012 0.202 ± 0.012 0.179 ± 0.019 0.217 ± 0.016 
NGT
IGT
AllFHFH+AllFHFH+
Insulin secretion       
    First-phase (pmol/l) 711 (651–777) 796 (718–883) 647 (562–745)* 467 (398–548) 449 (359–562) 480 (378–609)§ 
    Second-phase (pmol/l) 281 (261–304) 301 (272–334) 266 (239–297)| 203 (178–233) 209 (176–249) 199 (160–248)§ 
Insulin sensitivity (μmol · kg LBM−1 · min−1 · pmol−1 · l−10.236 ± 0.008 0.228 ± 0.011 0.242 ± 0.012 0.202 ± 0.012 0.179 ± 0.019 0.217 ± 0.016 

Data for insulin secretion are geometric means (95% CI). Data for insulin sensitivity are means ± SE.

*

P < 0.01

P < 0.001, all IGT vs. all NGT

P < 0.0001

§

P < 0.01, IGT family history (FH)+ vs. NGT FH+.

|

P < 0.05, NGT FH+ vs. NGT FH;

P < 0.02, IGT FH vs. NGT FH.

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