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TABLE 1

Effects of F11 on diabetic SMC migration by LTBP-1 and PDGF-BB

(μg IgG/ml)F11Control IgG
LTBP-1   
 0 57.6 ± 14.9  
 0.2 29.8 ± 7.01* 53.5 ± 12.9 
 1 31.6 ± 8.22* 57.0 ± 12.0 
PDGF-BB   
 0 61.3 ± 14.9  
 0.2 70.6 ± 10.1 59.5 ± 9.19 
 1 69.8 ± 7.50 69.0 ± 7.93 
(μg IgG/ml)F11Control IgG
LTBP-1   
 0 57.6 ± 14.9  
 0.2 29.8 ± 7.01* 53.5 ± 12.9 
 1 31.6 ± 8.22* 57.0 ± 12.0 
PDGF-BB   
 0 61.3 ± 14.9  
 0.2 70.6 ± 10.1 59.5 ± 9.19 
 1 69.8 ± 7.50 69.0 ± 7.93 

Data are means ± SD. Migration activities were assayed in diabetic SMCs with the addition of 100 pg/ml LTBP-1 (or 10 ng/ml PDGF-BB) and 0.2 and 1.0 μg IgG/ml F11 or control IgG.

*

P < 0.05 vs. no addition of F11.

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