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TABLE 3

Risk estimates of individuals according to circulating cytokine levels

MedianAge- and sex-adjusted analysis+BMI-adjusted analysisAdjusted for all risk factors*Adjusted for all risk factors and HbA1c
IL-1β      
 Category 1 0.09 (0.09–0.09) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 0.84 (0.13–5.52) 1.20 (0.84–1.72) 1.18 (0.79–1.75) 1.19 (0.78–1.79) 1.20 (0.74–1.96) 
CRP      
 Category 1 0.62 (0.09–1.49) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 3.57 (1.50–39.7) 3.5 (2.4–5.1) 2.2 (1.5–3.3) 1.9 (1.2–2.9) 1.9 (1.2–3.2) 
IL-6      
 Category 1 0.66 (0.11–0.90) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 1.19 (0.90–1.45) 1.77 (0.97–3.29) 1.36 (0.72–2.6) 1.22 (0.64–2.38) 1.14 (0.54–2.45) 
 Category 3 1.80 (1.45–2.24) 3.88 (2.21–7.03) 2.17 (1.18–4.07) 1.92 (1.02–3.67) 1.72 (0.83–3.60) 
 Category 4 3.30 (2.24–10.8) 7.34 (4.18–13.32) 3.26 (1.76–6.19) 2.75 (1.44–5.34) 2.57 (1.24–5.47) 
TNF-α      
 Category 1 0.79 (0.35–1.11) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 1.34 (1.11–1.56) 1.85 (1.11–3.11) 1.66 (0.94–2.95) 1.62 (0.90–2.94) 1.39 (0.95–3.85) 
 Category 3 1.82 (1.56–2.26) 1.40 (0.83–2.39) 1.05 (0.58–1.89) 1.04 (0.57–1.92) 1.06 (0.51–2.21) 
 Category 4 2.94 (2.26–15.15) 2.30 (1.37–3.90) 1.70 (0.96–3.04) 1.52 (0.84–2.78) 1.57 (0.78–3.18) 
MedianAge- and sex-adjusted analysis+BMI-adjusted analysisAdjusted for all risk factors*Adjusted for all risk factors and HbA1c
IL-1β      
 Category 1 0.09 (0.09–0.09) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 0.84 (0.13–5.52) 1.20 (0.84–1.72) 1.18 (0.79–1.75) 1.19 (0.78–1.79) 1.20 (0.74–1.96) 
CRP      
 Category 1 0.62 (0.09–1.49) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 3.57 (1.50–39.7) 3.5 (2.4–5.1) 2.2 (1.5–3.3) 1.9 (1.2–2.9) 1.9 (1.2–3.2) 
IL-6      
 Category 1 0.66 (0.11–0.90) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 1.19 (0.90–1.45) 1.77 (0.97–3.29) 1.36 (0.72–2.6) 1.22 (0.64–2.38) 1.14 (0.54–2.45) 
 Category 3 1.80 (1.45–2.24) 3.88 (2.21–7.03) 2.17 (1.18–4.07) 1.92 (1.02–3.67) 1.72 (0.83–3.60) 
 Category 4 3.30 (2.24–10.8) 7.34 (4.18–13.32) 3.26 (1.76–6.19) 2.75 (1.44–5.34) 2.57 (1.24–5.47) 
TNF-α      
 Category 1 0.79 (0.35–1.11) 1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference) 
 Category 2 1.34 (1.11–1.56) 1.85 (1.11–3.11) 1.66 (0.94–2.95) 1.62 (0.90–2.94) 1.39 (0.95–3.85) 
 Category 3 1.82 (1.56–2.26) 1.40 (0.83–2.39) 1.05 (0.58–1.89) 1.04 (0.57–1.92) 1.06 (0.51–2.21) 
 Category 4 2.94 (2.26–15.15) 2.30 (1.37–3.90) 1.70 (0.96–3.04) 1.52 (0.84–2.78) 1.57 (0.78–3.18) 

Data are OR (95% CI), unless otherwise indicated.

Median (category limits),

Median (interquartile range). Individuals were divided into quartiles according to their baseline plasma concentrations of IL-6 or TNF-α. They were dichotomized according to their levels of IL-1β and CRP;

*

adjusted for age, sex, BMI, WHR, sporting activities, smoking status, alcohol consumption, and educational attainment.

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