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TABLE 3

Cox proportional hazards models for prediction of CV disease mortality

Total population (n = 994)
No CHD (n = 742)
Possible or definite CHD (n = 252)
HR95% CIχ2PHR95% CIχ2PHR95% CIχ2P
Adjusted for study center only             
 STD             
  ≥50 μV 9.54 5.43–16.73 61.9 <0.001 12.03 4.95–29.25 30.1 <0.001 6.15 2.76–13.71 19.7 <0.001 
  PCA ratio* 3.17 1.81–5.56 16.3 <0.001 2.38 0.98–5.79 3.7 0.055 2.81 1.26–6.25 6.4 0.012 
  QTc >460 ms 2.07 1.13–3.79 5.6 0.018 2.22 1.03–4.94 3.9 0.048 1.72 0.68–4.33 1.3 0.251 
Adjusted for multiple covariates             
 STD             
   ≥50 μV 3.68 1.70–7.96 10.9 <0.001 7.89 2.28–27.28 10.7 <0.001 6.84 2.90–16.14 19.3 <0.001 
  PCA ratio* 2.61 1.33–5.13 7.7 0.006 2.12 0.70–6.47 1.8 0.186 2.24 0.91–5.51 3.1 0.079 
  QTc >460 ms 1.87 0.92–3.79 3.0 0.082 2.55 1.01–6.56 3.8 0.049 2.87 1.07–7.68 4.4 0.036 
Total population (n = 994)
No CHD (n = 742)
Possible or definite CHD (n = 252)
HR95% CIχ2PHR95% CIχ2PHR95% CIχ2P
Adjusted for study center only             
 STD             
  ≥50 μV 9.54 5.43–16.73 61.9 <0.001 12.03 4.95–29.25 30.1 <0.001 6.15 2.76–13.71 19.7 <0.001 
  PCA ratio* 3.17 1.81–5.56 16.3 <0.001 2.38 0.98–5.79 3.7 0.055 2.81 1.26–6.25 6.4 0.012 
  QTc >460 ms 2.07 1.13–3.79 5.6 0.018 2.22 1.03–4.94 3.9 0.048 1.72 0.68–4.33 1.3 0.251 
Adjusted for multiple covariates             
 STD             
   ≥50 μV 3.68 1.70–7.96 10.9 <0.001 7.89 2.28–27.28 10.7 <0.001 6.84 2.90–16.14 19.3 <0.001 
  PCA ratio* 2.61 1.33–5.13 7.7 0.006 2.12 0.70–6.47 1.8 0.186 2.24 0.91–5.51 3.1 0.079 
  QTc >460 ms 1.87 0.92–3.79 3.0 0.082 2.55 1.01–6.56 3.8 0.049 2.87 1.07–7.68 4.4 0.036 
*

>32.0% in women, >24.6% in men.

Cox model with all three ECG variables entered, adjusted for age, BMI, diastolic and systolic blood pressures, fasting glucose, GHb, HDL and LDL cholesterol levels, triglyceride level, albuminuria, alcohol use, history of smoking, QTc interval, and study center. Prevalent CHD was included as a covariate only in the total population. HR, hazard ratio.

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